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Ulcerative Colitis (UC) is a rapidly evolving medical field, and will continue to be very exiting in the next few decades. Although the underlying cause of this disease is still unknown, results in research dealing with various issues related to this disease are published every day. Chapters included in this book review the most recent literature on related advancements in regard to this chronic disease, which is controllable but not curable. Aspects like epidemiology, pathophysiology, genetics, incriminated etiologies, clinical aspects, complications, and disease management, including advancements in the diagnostic and therapeutic options, were documented by well known clinicians, researchers, and world wide authorities in their fields. This book on UC will be a valuable addition to each doctor's library interested in this subject, or for physicians dealing with patients suffering from this disease. Authors have also included figures and diagrams to depict their point, and to easily reach the minds of the readers in the simplest way.

Ulcerative colitis. --- Colitis --- Inflammatory bowel diseases --- Hepatology

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80% of the bodies’ immune cells are harbored within the intestine. They are only separated from 1014 microorganisms by a single layer of intestinal epithelial cells and a secreted superficial mucus layer. Therefore, the intestinal epithelial surface represents a main frontier in host defense. Providing an intact mucosal barrier is vital for the host to limit bacterial entry and spread to the circulation. This specialized localization requires dynamic responses of intestinal epithelial cells to both pathogen- and immune-derived signals. Moreover, emergency barriers are needed in the setting of epithelial damage, which allow provisional microbial control and a timely restitution of mucosal integrity. Epithelial cells constantly interact with subjacent immune cells and fibroblasts, actively directing the immune response and also shaping the luminal microbiota. Epithelial dysfunction has been appreciated in recent years as a driving element in the pathogenesis of Inflammatory Bowel Diseases (IBD). Additionally, primary immune deficiencies may manifest in the form of chronic intestinal inflammation mimicking features of IBD. Recent advances in the techniques of epithelial cell culture and the discovery of new immune cell types and cellular properties have tremendously advanced the understanding in this interesting field of research. In this research topic, we want to focus on the complex interaction of intestinal epithelial cells, luminal flora and adjacent immune cells and invite manuscripts which highlight the dynamic responses of both epithelium and immune cells under steady-state or inflammatory conditions, and envision how this may be translated to the benefit of patient-care.

lymphocytes --- inflammatory bowel diseases --- immune system --- intestinal epithelium --- mucosal immunity

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The incidence of chronic inflammatory and autoimmune diseases is steadily increasing. Inflammatory bowel disease (IBD) is one example of a chronic inflammatory disease, which primarily affects the intestine but may also affect extraintestinal organs. The exact pathogenesis of IBD is currently unknown. However, it is clear that the pathogenesis is complex, involving barrier defects, changes in the intestinal microbiome, and chronic immune activation. This book aims to summarize basic aspects of these complex interactions between barrier function, microbiome, and the immune system. Of note, there is currently no cure for IBD. However, several therapies have evolved in the last years, which are overall able to-at least temporarily-suppress IBD. These therapies and the underlying mechanism are discussed.

Inflammatory bowel diseases. --- IBD (Disease) --- Inflammatory bowel disease --- Intestines --- Gastroenteritis --- Inflammation --- Medicine --- Hepatology --- Gastroenterology --- Health Sciences

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In this book, several important points regarding Crohn's disease are discussed. In the first section, we focus on etiopathogeny of Crohn's disease and the recent advances in our overall understanding of the disease - specifically, the role of the gut epithelium, alterations of the epithelial crypts, and the roles of the different cytokines in the pathophysiology of Crohn's disease. In the second section, a diagnosis of Crohn's disease is discussed. Another particular area of focus is in the diagnosis of intestinal tuberculosis, and the role of mycobacterium avium in Crohn's disease. In the third and final section, the management of Crohn's disease is discussed, with a focus on recent evidence-based medicine recommendations.

Crohn's disease --- Diagnosis. --- Colitis, Granulomatous --- Crohn disease --- Enteritis, Regional --- Granulomatous colitis --- Granulomatous enteritis --- Ileitis, Regional --- Ileocolitis --- Regional enteritis --- Regional ileitis --- Terminal enteritis --- Inflammatory bowel diseases --- Hepatology

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A peer-reviewed, online-only, open access journal. Publishes engaging and informative content that catalyzes dialogue on state-of-the-art comprehensive care for patients with inflammatory bowel disease (IBD) alongside the latest research to advance prevention, treatment and cures. The journal provides a forum for the dissemination of novel insights and innovations across key disciplines involved in IBD care.

Crohn's disease. --- Crohn Disease. --- Inflammatory Bowel Diseases. --- Gastrointestinal Diseases. --- Digestive System Diseases. --- Digestive System Disease --- Disease, Digestive System --- Diseases, Digestive System --- System Disease, Digestive --- System Diseases, Digestive --- Functional Gastrointestinal Disorders --- Gastrointestinal Disorders, Functional --- Cholera Infantum --- Disease, Gastrointestinal --- Diseases, Gastrointestinal --- Disorder, Functional Gastrointestinal --- Disorders, Functional Gastrointestinal --- Functional Gastrointestinal Disorder --- Gastrointestinal Disease --- Gastrointestinal Disorder, Functional --- Infantum, Cholera --- Gastroenterology --- Bowel Diseases, Inflammatory --- Inflammatory Bowel Disease --- Crohn's Disease --- Crohn's Enteritis --- Inflammatory Bowel Disease 1 --- Regional Enteritis --- Colitis, Granulomatous --- Enteritis, Granulomatous --- Enteritis, Regional --- Ileitis, Regional --- Ileitis, Terminal --- Ileocolitis --- Crohns Disease --- Granulomatous Colitis --- Granulomatous Enteritis --- Regional Ileitides --- Regional Ileitis --- Terminal Ileitis --- Crohn disease --- Granulomatous colitis --- Granulomatous enteritis --- Regional enteritis --- Regional ileitis --- Terminal enteritis --- Inflammatory bowel diseases --- Digestive System Disorders --- Hepatobiliary Diseases --- Hepatobiliary Disorders --- Digestive System Disorder --- Hepatobiliary Disease --- Hepatobiliary Disorder --- System Disorders, Digestive --- Gastrointestinal Disorders --- Gastrointestinal Disorder --- Colitis. --- Irritable Bowel Syndrome. --- Colitides --- Colitis, Mucous --- Colon, Irritable --- Colitides, Mucous --- Irritable Bowel Syndromes --- Irritable Colon --- Mucous Colitides --- Mucous Colitis --- Syndrome, Irritable Bowel --- Syndromes, Irritable Bowel --- crohn's disease --- colitis --- inflammatory bowel disease