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Erectile dysfunction is a widespread problem, affecting many men across all age groups and it is more than a serious quality of life problem for sexually active men. This book contains chapters written by widely acknowledged experts, each of which provides a unique synthesis of information on emergent aspects of ED. All chapters take into account not only the new perspectives on ED but also recent extensions of basic knowledge that presage directions for further research. The approach in this book has been to not only describe recent popular aspects of ED, such as basic mechanism updates, etiologic factors and pharmacotherapy, but also disease-associated ED and some future perspectives in this field.
Erectile Dysfunction. --- E.D. (Erectile dysfunction) --- ED (Erectile dysfunction) --- Erectile dysfunction --- Impotency --- Sexual disorders --- Urology & urogenital medicine
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Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.
nerve conduit --- tissue engineering --- regenerative medicine --- mixed lymphocyte reaction --- histological images --- future scaffold engineering --- multiparameter --- 3DPVS --- MSCs --- Wnt signaling --- Mesenchymal Stromal Cells --- factorial design --- novel scaffold --- Wharton’s Jelly tissue --- stem cells --- umbilical arteries --- SDS --- platelet rich plasma --- TGF? signaling --- traditional scaffold --- pluripotency and commitment --- tissue engineered construct --- HLA-G --- CHAPS --- platelets --- proteomic analysis --- vibrating nature of universe. --- VS55 --- cell culture --- FGF signaling --- evolution of scaffold --- dynamicity and dimensionality --- fibrin gel --- scaffold classification --- decellularization --- vitrification --- seven-folder logics --- IIEF-5 questionnaire --- TGF-?1 --- erectile dysfunction --- human induced pluripotent stem cells --- iPSCs --- scaffolds --- Barret’s esophagus --- nerve regeneration --- long term storage --- laws of system evolution --- scaffold categorization --- platelet lysate --- 3D scaffold --- esophagus --- language of relativity --- cord blood units
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Nutrition, often along with physical activity, is by now acknowledged as a cornerstone in the prevention and even more so the treatment of many diseases. Indeed, food and nutritional intake nowadays are often thought to be the main source of wellbeing sometimes over- but also underestimating the impact of nutritional intake, dietary pattern and food-derived natural compounds in their impact on human health. In this Special Issue entitled `Clinical Nutrition: Recent Advances and Remaining Challenges´ a broad overview and summary on recent findings in various fields of clinical nutrition with special focus on chronic and degenerative diseases like metabolic diseases, cancers, neurodegenerative diseases, inflammatory bowel diseases, sarcopenia but also malnutrition in elderly, infants and children is provided. Nutrition, often along with physical activity, is by now acknowledged as a cornerstone in the prevention and even more so the treatment of many diseases. Indeed, food and nutritional intake nowadays are often thought to be the main source of wellbeing sometimes over- but also underestimating the impact of nutritional intake, dietary pattern and food-derived natural compounds in their impact on human health. In this Special Issue entitled `Clinical Nutrition: Recent Advances and Remaining Challenges´ a broad overview and summary on recent findings in various fields of clinical nutrition with special focus on chronic and degenerative diseases like metabolic diseases, cancers, neurodegenerative diseases, inflammatory bowel diseases, sarcopenia but also malnutrition in elderly, infants and children is provided.
Research & information: general --- Biology, life sciences --- Food & society --- malnutrition --- cirrhosis --- nutritional screening --- nutritional assessment --- gut–liver axis --- macronutrients --- micronutrients --- dysbiosis --- diet --- enteral nutrition --- inflammatory bowel disease --- nutrition --- nutritional therapy --- prevention --- artificial nutrition --- nasogastric feeding --- nasogastric tube --- palliative care --- calcium oxalate stone formation --- dietary assessment --- fatty acids --- fluid --- oxalate --- protein --- sodium --- uric acid --- water --- insulin --- lifestyle --- non-alcoholic --- steatohepatitis --- fibrosis --- metabolic syndrome --- weight loss --- time-restricted feeding --- intermittent fasting --- low-carb diet --- liver disease --- Brugada syndrome --- long QT syndrome --- ingredients --- glucose --- ketone bodies --- ROS --- sudden cardiac death --- bariatric surgery --- cardiovascular disease --- endovascular bariatric surgery --- obesity --- oral nutritional supplements --- perioperative nutrition --- sarcopenia --- gastrointestinal surgery --- behaviour --- nutrition supplements --- type 2 diabetes --- ageing --- inflammaging --- anorexia of aging --- DoMAP --- GLIM criteria --- cholestasis --- chronic liver diseases --- nutritional needs --- pediatrics --- medical nutrition therapy --- critical care --- parenteral nutrition --- energy --- review --- Crohn’s disease --- gut microenvironment --- celiac disease --- gluten --- gluten-free diet --- prostate --- metabolism --- benign prostatic hyperplasia --- erectile dysfunction --- dietary recommendation --- overweight --- carbohydrate --- fat
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An interdisciplinary book that brings together, at an international level, a high-quality collection of reviews and original research articles dealing with the importance of natural or synthetic polymers in encapsulation processes and their applications. A deep understanding and relevant theoretical calculations for exploring the functions of the materials (involved in the formulations) have also been presented along with fundamental investigations. This book has explored the latest research on the function of polymers in encapsulation technology including fundamental theory and experiments together with reviews and articles. Moreover, the present book offers easy-to-achieve approaches that have been developed so far and could create a platform for industrial material production.
microemulsion --- doxorubicin --- in vitro --- cytotoxicity --- lignin (LGN) --- polyacrylate --- water-based latex --- Pickering emulsion --- microencapsulation --- controlled release --- encapsulation --- clozapine --- schizophrenia --- polymeric nanocarriers --- D2-5-HT1A receptor heterodimers --- scFv antibodies --- paraffin PCM—melamine-formaldehyde microcapsules --- outer shell --- modification by MWCNTs and PEDOT: PSS --- differential scanning calorimetry --- dip coating --- thermal conductivity and heat storage and release capacity --- dynamic thermal behaviour --- hydrogels --- redox-responsive polymers --- TEMPO --- encapsulation-release --- catalysis --- ion-sensitive systems --- drug delivery --- smart pharmaceutical systems --- biocompatible medical devices --- polyethyleneimine --- micelles --- palladium --- nanoparticles --- catalytic --- aerosol-assisted deposition --- open-air plasma --- entrapment in coating --- acrylic acid --- ethylcellulose --- lung cancer --- nanosponge --- oral bioavailability --- systolic blood pressure --- nanomicelles --- artemisinin --- cornea --- toxicity --- erectile dysfunction --- Kolliphor® P188 --- Kollidon® 30 --- Kollidon®-VA64 --- polymer --- sildenafil citrate --- natural polymers --- polymeric capsules --- porous polymeric spheres --- active pharmaceutical carriers --- stimuli-responsive release --- cell culture platforms --- n/a --- paraffin PCM-melamine-formaldehyde microcapsules
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Sexuality is considered as a great human value related to happiness and satisfaction, but unfortunately, when affecting mental disorders, they tend to be associated with second level human functions. Nevertheless, sexual dysfunction often accompanies psychiatric disorder, intensely influencing compliance, quality of life and human relationships. Sexuality could be influenced either by a mental disorder itself, difficulties to get and maintain couple relationships or by the use of psychotropic treatments. Treatment-related adverse events are unfortunately under-recognized by clinicians, scarcely spontaneously communicated by patients, and rarely investigated in clinical trials. The most frequent psychotropic compounds that could deteriorate sexuality and quality of life include antidepressants, antipsychotics and mood regulators. There are important differences between them related to some variations in mechanisms of action including serotonin, dopamine and prolactin levels. Little is known about the relevance of sexuality and its dysfunctions in chronic and frequent mental and neurological disorders, such as psychosis, mood disorders, anxiety, phobias, eating disorders, alcohol or drug dependencies, epilepsy and childhood pathology. Poor sexual life, low satisfaction and more frequent risky sex behavior than in the general population are associated with severe mental diseases. There is a need for increasing research in this field, including epidemiological, psychological, neurophysiological, neuroanatomical and genetic variables related to sexual life to get a better understanding of the implicated mechanisms. To increase the sensibility of clinicians, the identification and management of sexual disturbances after the onset of any mental disorder should be highlighted. This would avoid unnecessary suffering and deterioration of quality of life.
online pornography --- addiction --- cybersex --- internet --- compulsive sexual behavior --- hypersexuality --- dopaminergic system --- paroxetine --- agomelatine --- immunohistochemical study --- sexual dysfunction --- male rats --- sexual addiction --- sexual compulsivity --- phenomenology --- comorbidities --- opioid-related disorders --- methadone --- adverse effects --- erectile dysfunction --- medication adherence --- erotic stimulus processing --- serotonin --- noradrenaline --- dopamine --- fMRI --- healthy --- human --- sexual communication anxiety --- sexual perfectionism --- parent-child communication --- risky sexual behavior --- child sexual abuse --- female perpetrator --- mother-child incest --- gender stereotypes --- social taboo --- transgender --- anxiety --- depression --- social loneliness --- romantic loneliness --- autism --- sexual satisfaction --- Asperger syndrome --- sexual desire --- lubrication --- sexual intercourse --- sexual excitation --- sexual inhibition --- post-traumatic stress disorder --- veterans --- predictors --- sexuality --- mental health --- mental disorder --- hidradenitis suppurativa --- sexual abstinence --- partner status --- prison inmates --- eye tracking --- non-consensual image sharing --- intimate images --- objectification --- objectifying gaze --- rape myth acceptance --- sexting --- desvenlafaxine --- antidepressant --- treatment --- prsexdq-salsex questionnaire --- switching strategy --- female sexual dysfunction --- hormonal contraceptive --- libido --- desire --- sex life --- orgasm --- vaginal ring --- depot medroxyprogesterone acetate --- pornography --- delayed ejaculation --- NeMUP --- child sexual offending --- pedophilia --- SCID --- peyronie’s disease --- penile induration --- patient satisfaction --- research
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