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Marine Drugs is glad to announce its first Special Issue book on “ion channels” related research: Under the great stewardship of the Guest Editor, Dr. Jean-Marc Sabatier, four advanced research articles and three comprehensive review papers were collected in the Special Issue “Ion Channels as Marine Drug Targets”. Join us to explore the advanced research outcomes in this field: α-Conotoxin RgIA and a potent analog, RgIA4, in treatment of pain; botulinum toxin-chitosan nanoparticles in treatment of atrial fibrillation; 27-amino acid (aa)-long δ-conotoxin TxVIA that modulates mammalian CaV3.x; first venomics study of Conus tulipa venom; review on marine toxins targeting Kv1 channels; review on synthetic approaches to zetekitoxin AB; and review on marine natural products and drug resistance in latent tuberculosis. The second edition of this Special Issue is open for submissions, we look forward to your contribution.

conotoxin --- Conus tulipa --- intraspecific variation --- venomics --- transcriptomics --- proteomics --- conantokins --- net hunting strategy --- nirvana cabal --- ion channel modulators --- marine anti-TB compounds --- PZA --- MTB --- latent TB --- sponges --- nicotinic --- chemotherapy --- paclitaxel --- taxane --- neuropathic pain --- α9α10 --- saxitoxin --- zetekitoxin AB --- voltage-gated sodium channel --- guanidine alkaloid --- bioactives --- conotoxins 2 --- Kv1 --- marine toxins --- modulators --- potassium channels --- sea anemone toxins --- TxVIA --- mammalian NaV channel --- selective inhibitor --- T-type CaV3.2 --- botulinum toxin A1 --- chitosan nanoparticles --- antiarrhythmics --- pharmacological models of arrhythmia --- electrically induced arrhythmia

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The rapid aging of populations in developed countries since the 2000s has placed increasing attention on the issue of musculoskeletal disorders in elderly patients. Notably, spinal disorders not only restrict the social activities of elderly patients, but they also lead to economic loss for society. “Current Advances in Spinal Diseases of Elderly Patients” is a topical collection of articles about current perspectives on diagnosis and treatment of spinal disorders including current surgical strategies. This Special Issue covers a broad range of issues, ranging from managing refractory states such as severe osteoporosis, spinal deformity, ossification of the spinal ligaments, and multiple arthropathy to managing lifestyle-related spinal diseases during the COVID-19 pandemic in elderly populations. We hope that the readers of this Special Issue find the contents interesting.

spinal metastasis --- non-small cell lung cancer --- decompression --- survival --- prognosis --- epidermal growth factor receptor --- Uno’s C-index --- New England Spinal Metastasis Score --- trunk muscle --- bioelectrical impedance analysis --- MRI --- back muscle strength --- epidemiological study --- osteoporosis --- osteopenia --- locomotive syndrome --- two-step test --- frailty --- cervical myelopathy --- hand grip strength --- falls --- postoperative --- human nonmercaptalbumin --- reduced albumin --- oxidative stress --- spinal sagittal alignment --- low back pain --- health-related quality of life --- conus medullaris --- height --- pelvic incidence --- magnetic resonance imaging --- healthy volunteers --- n/a --- gender differences --- spine arthrodesis --- spinal fusion --- spine --- deformity --- direct lateral corpectomy --- expandable cage --- global alignment --- local kyphosis --- osteoporosis vertebral fracture --- cervical spine --- clinical findings --- computed tomography --- diffuse idiopathic skeletal hyperostosis --- ossification of the posterior longitudinal ligament --- pain --- patient-reported outcomes --- whole spine --- prevalence --- influence factor --- spinal alignment --- aging --- total knee arthroplasty --- lumbar lordosis --- sagittal spinopelvic parameters --- clinical outcome --- cervical ossification of the posterior longitudinal ligament --- whole-spine computed tomography --- grading system --- multicenter study --- adult spinal deformity (ASD) --- posterior lumbar interbody fusion --- lateral lumbar interbody fusion --- sagittal correction --- perioperative complications --- surgical invasiveness --- degenerative adult deformity --- anterior cervical corpectomy and fusion --- hybrid fusion --- implant failure --- graft subsidence --- complications --- perioperative outcomes --- fusion rate --- segmental paralysis --- mechanical stability --- resident cohort --- resident registry --- spinal balance --- gender --- adult spine --- osteoporotic vertebral fracture --- residual pain --- visual analog scale --- quality of life --- adult spine deformity --- adult spine fusion --- deformity correction --- perioperative parameters --- ODI --- VAS --- disability --- T1 slope --- C2-7 SVA --- C2-7 angle --- back pain --- brace --- spine orthoses --- lumbar support --- spine support --- COVID-19 --- pandemic --- spinal disorder --- elderly --- exercise habit --- female --- activities of daily living --- nutrition --- health checkup data --- full-endoscopic lumbar discectomy --- recurrent herniation --- early recurrence --- Uno's C-index