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The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers’ drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling.

Cyp26 enzymes --- congenital anomalies --- CRE/LoxP --- hedgehog signaling --- mouse models --- retinoic acid --- smoothened --- sonic hedgehog --- sonic hedgehog (SHH) --- oral squamous cell carcinoma (OSCC) --- tumor microenvironment (TME) --- tumor-associated macrophages (TAMs) --- cancer-associated fibroblasts (CAFs) --- tumor-associated angiogenesis --- hedgehog --- growth plate --- endochondral ossification --- chondrocyte --- osteoblast --- bone disease --- TMJ --- synovial joint --- articular disc --- Ihh --- PTHrP --- osteoarthritis --- epithelial–mesenchymal interaction (EMI) --- prostate cancer --- external genitalia --- androgen --- basement membrane --- bone morphogenetic protein --- stem cell --- animal experiment --- fracture healing --- cancer stem cells --- hypospadias --- urethra --- penis --- bone --- hedgehog signalling --- tooth development --- epithelial and mesenchymal interaction --- Gli1 --- mesenchymal stem cell --- lineage tracing analysis --- stem cell marker --- n/a --- epithelial-mesenchymal interaction (EMI)