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Complexity is a ubiquitous phenomenon in physiology that allows living systems to adapt to external perturbations. Fractal structures, self-organization, nonlinearity, interactions at different scales, and interconnections among systems through anatomical and functional networks, may originate complexity. Biomedical signals from physiological systems may carry information about the system complexity useful to identify physiological states, monitor health, and predict pathological events. Therefore, complexity analysis of biomedical signals is a rapidly evolving field aimed at extracting information on the physiological systems. This book consists of 16 contributions from authors with a strong scientific background in biomedical signals analysis. It includes reviews on the state-of-the-art of complexity studies in specific medical applications, new methods to improve complexity quantifiers, and novel complexity analyses in physiological or clinical scenarios. It presents a wide spectrum of methods investigating the entropic properties, multifractal structure, self-organized criticality, and information dynamics of biomedical signals touching upon three physiological areas: the cardiovascular system, the central nervous system, the heart-brain interactions. The book is aimed at experienced researchers in signal analysis and presents the latest trends in the complexity methods in physiology and medicine with the hope of inspiring future works advancing this fascinating area of research.

autonomic nervous function --- heart rate variability (HRV) --- baroreflex sensitivity (BRS) --- photo-plethysmo-graphy (PPG) --- digital volume pulse (DVP) --- percussion entropy index (PEI) --- heart rate variability --- posture --- entropy --- complexity --- cognitive task --- sample entropy --- brain functional networks --- dynamic functional connectivity --- static functional connectivity --- K-means clustering algorithm --- fragmentation --- aging in human population --- factor analysis --- support vector machines classification --- Sampen --- cross-entropy --- autonomic nervous system --- heart rate --- blood pressure --- hypobaric hypoxia --- rehabilitation medicine --- labor --- fetal heart rate --- data compression --- complexity analysis --- nonlinear analysis --- preterm --- Alzheimer’s disease --- brain signals --- single-channel analysis --- biomarker --- refined composite multiscale entropy --- central autonomic network --- interconnectivity --- ECG --- ectopic beat --- baroreflex --- self-organized criticality --- vasovagal syncope --- Zipf’s law --- multifractality --- multiscale complexity --- detrended fluctuation analysis --- self-similarity --- sEMG --- approximate entropy --- fuzzy entropy --- fractal dimension --- recurrence quantification analysis --- correlation dimension --- largest Lyapunov exponent --- time series analysis --- relative consistency --- event-related de/synchronization --- motor imagery --- vector quantization --- information dynamics --- partial information decomposition --- conditional transfer entropy --- network physiology --- multivariate time series analysis --- State–space models --- vector autoregressive model --- penalized regression techniques --- linear prediction --- fNIRS --- brain dynamics --- mental arithmetics --- multiscale --- cardiovascular system --- brain --- information flow