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The book delves into the intricate interplay of stress and adaptive responses, and their multifaceted dynamics influenced by stress type, exposure duration, genetic factors, and lifestyle elements. It unveils the complexity of stress management, unveiling how adaptive strategies evolve in response to stressors. By harnessing scientific breakthroughs in stress response comprehension, the book navigates the path to effective stress mitigation. Through avenues such as pharmacological interventions, dietary adjustments, psychological enhancement, and more, the book advocates for achieving adaptive resilience—a state where the system effectively copes with stress. The text encapsulates an array of stressors, including extreme stress, oxidative stress, and genotoxic stress, dissecting their impact on systemic equilibrium and health. The book's focal point rests on adaptive mechanisms that vary with stressor types, while also spotlighting how these mechanisms can be calibrated through pharmacological and alternative means. This is an invaluable resource for understanding, mitigating, and harnessing the power of adaptation in the face of stress-induced challenges.

Pharmacology. --- Nutrition. --- Cytology. --- Stress (Physiology). --- Cellular Stress. --- Stress (Physiology)

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The book dissects the role of oxidative stress in the pathogenesis of the leading causes of global morbidity and mortality, i.e.cardiovascular and metabolic diseases. The chapters discuss topics related to the role reactive oxygen species (ROS) play in hypertension, atherosclerosis,diabetes, obesity and related pathologies. The authors also shed light on gender differences in the onset and pathologies of some of these diseases. Moreover, how ROS and aging interplay to precipitate cardiovasculo-metabolic disease is discussed and highlighted. Preventive measures that can abrogate ROS-induced cardiovasclo-metabolic disease are discussed and clarified in the hope of reducing such a debilitating battery of diseases. A section dedicated to antioxidants as potential therapy is also included. Furthermore, given the complexity of the mechanisms implicated in ROS-modulated responses, it remains challenging to assert a conclusive argument and pre-determined regimen for incorporating antioxidants into conventional therapies. Nonetheless, results from some clinical trials appear promising, warranting the addition of a chapter dedicated to such human trials. In all of the chapters, the molecular, cellular, genetic, and pharmacological mechanisms implicated are covered from an applied science perspective. This is an ideal book for basic researchers in the biomedical field, graduate students in biological and biomedical fields, medical students, instructors in medical and graduate schools, and professionals working for pharmaceutical companies.

Cytology. --- Stress (Physiology). --- Cardiovascular system. --- Physiology. --- Metabolism. --- Molecular biology. --- Cellular Stress. --- Cell Biology. --- Cardiovascular Physiology. --- Molecular Biology. --- Stress (Physiology)

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This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field. The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.

Cytology. --- Stress (Physiology). --- Biomolecules. --- Physical biochemistry. --- Macromolecules. --- Diseases. --- Proteins. --- Cellular Stress. --- Structural Biology. --- Mechanisms of Disease. --- Protein Biochemistry. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Medicine --- Epidemiology --- Health --- Pathology --- Sick --- Molecules --- Supramolecular chemistry --- Biophysical chemistry --- Biochemistry --- Physical organic chemistry --- Biological molecules --- Molecular biology --- Physiological stress --- Tension (Physiology) --- Adaptation (Biology) --- Cell biology --- Cellular biology --- Biology --- Cells --- Diseases --- Stress (Physiology)

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The writings of earliest civilizations reveal that diabetes mellitus has afflicted man for a very long time. Unfortunately, however, we are now experiencing a world-wide pandemic of the disease which has not been adequately addressed.  Available evidence suggests that worldwide every 10 seconds one patient dies of diabetes and its severe complications.  The outlook is even more bleak with the prediction of half of a billion diabetic patients by the year 2030.  The cost-impact of the disease poses a major challenge for both developed and developing countries and their economies. Thus, it is high time to reconsider and revise the current strategies in diabetes care.  Accordingly, a paradigm shift from reactive to perspective medicine has become a timely consideration.  This shift is based on the concept of Predictive, Preventive and Personalized Medicine (PPPM). The rationale for PPPM relates to the recognition that prediction of persons at high risk for the disease (i.e., diabetes mellitus) should help devise strategies to prevent its target organ complications, and create effective treatments tailored to the individual patient, thereby reducing morbidity, and associated costs, and mortality. The current book entitled “New Strategies to Advance Pre/Diabetes Care: Integrative Approach by PPPM” is intended to serve as a reference source for researchers and the healthcare industry with a special emphasis on health promotion in the general population and help design innovative strategies to prevent the onset of diabetes mellitus and its secondary complications.

Diabetes -- Alternative treatment. --- Diabetes mellitus. --- Integrative medicine. --- Diabetes --- Alternative treatment. --- Medical pluralism --- Medicine. --- Diabetes. --- Endocrinology. --- Metabolic diseases. --- Nephrology. --- Oxidative stress. --- Biomedicine. --- Biomedicine general. --- Oxidative Stress. --- Metabolic Diseases. --- Medicine --- Alternative medicine --- Cytology. --- Internal medicine --- Hormones --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Kidneys --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Endocrinology . --- Biomedicine, general. --- Oxidation-reduction reaction --- Stress (Physiology) --- Stress (Physiology). --- Diseases. --- Biomedical Research. --- Cellular Stress. --- Research. --- Biological research --- Biomedical research --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Epidemiology --- Health --- Sick --- Physiological stress --- Tension (Physiology) --- Adaptation (Biology)

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Attaining sustainable agricultural production while preserving environmental quality, agro-ecosystem functions and biodiversity represents a major challenge for current agricultural practices; further, the traditional use of chemical inputs (fertilizers, pesticides, nutrients etc.) poses serious threats to crop productivity, soil fertility and the nutritional value of farm produce. Given these risks, managing pests and diseases, maintaining agro-ecosystem health, and avoiding health issues for humans and animals have now become key priorities. The use of PGPR as biofertilizers, plant growth promoters, biopesticides, and soil and plant health managers has attracted considerable attention among researchers, agriculturists, farmers, policymakers and consumers alike. Using PGPR as bioinoculants can help meet the expected demand for global agricultural productivity to feed the world’s booming population, which is predicted to reach roughly 9 billion by 2050. However, to provide effective bioinoculants, PGPR strains must be safe for the environment, offer considerable plant growth promotion and biocontrol potential, be compatible with useful soil rhizobacteria, and be able to withstand various biotic and abiotic stresses. Accordingly, the book also highlights the need for better strains of PGPR to complement increasing agro-productivity.

Plant growth-promoting rhizobacteria. --- PGPR (Bacteria) --- Rhizobacteria --- Growth (Plants) --- Plant physiology. --- Sustainable development. --- Oxidative stress. --- Plant breeding. --- Plant pathology. --- Plant Physiology. --- Sustainable Development. --- Oxidative Stress. --- Plant Breeding/Biotechnology. --- Plant Pathology. --- Botany --- Communicable diseases in plants --- Crop diseases --- Crops --- Diseases of plants --- Microbial diseases in plants --- Pathological botany --- Pathology, Vegetable --- Phytopathology --- Plant pathology --- Plants --- Vegetable pathology --- Agricultural pests --- Crop losses --- Diseased plants --- Phytopathogenic microorganisms --- Plant pathologists --- Plant quarantine --- Agriculture --- Breeding --- Oxidation-reduction reaction --- Stress (Physiology) --- Development, Sustainable --- Ecologically sustainable development --- Economic development, Sustainable --- Economic sustainability --- ESD (Ecologically sustainable development) --- Smart growth --- Sustainable development --- Sustainable economic development --- Economic development --- Physiology --- Pathology --- Diseases and pests --- Diseases --- Wounds and injuries --- Environmental aspects --- Sustainability. --- Cytology. --- Stress (Physiology). --- Plant biotechnology. --- Plant diseases. --- Cellular Stress. --- Plant Biotechnology. --- Crop biotechnology --- Agricultural biotechnology --- Physiological stress --- Tension (Physiology) --- Adaptation (Biology) --- Cell biology --- Cellular biology --- Biology --- Cells --- Sustainability science --- Human ecology --- Social ecology --- Biotechnology