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This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

Zinc-finger proteins. --- Zinc-finger proteins --- Gold compounds. --- Inhibitors. --- Auric compounds --- Aurous compounds --- Chemicals --- Zinc fingers --- Zinc proteins --- Chemistry, inorganic. --- Chemistry, Organic. --- RNA-ligand interactions. --- Mass spectrometry. --- Bioorganic chemistry. --- Immunology. --- Inorganic Chemistry. --- Organometallic Chemistry. --- Protein-Ligand Interactions. --- Mass Spectrometry. --- Bioorganic Chemistry. --- Immunobiology --- Life sciences --- Serology --- Bio-organic chemistry --- Biological organic chemistry --- Biochemistry --- Chemistry, Organic --- Mass spectra --- Mass spectrograph --- Mass spectroscopy --- Mass spectrum analysis --- Mass (Physics) --- Nuclear spectroscopy --- Spectrum analysis --- Organic chemistry --- Chemistry --- Inorganic chemistry --- Inorganic compounds --- Inorganic chemistry. --- Organometallic chemistry . --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Chemistry, Organometallic --- Metallo-organic chemistry

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For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile.

?–? stacking --- encapsulation --- n/a --- oxindolimine–metal complexes --- cyclodextrin --- platinum iodido complexes --- distribution coefficient --- antiproliferative activity --- anticancer agents --- nanotubes --- ruthenium --- platinum --- Log kw --- nanoparticles --- drug discovery --- metal complex --- metallodrugs --- isatin-derived ligands --- anticancer drug --- upconverting nanoparticles --- pyridine benzimidazole --- dendrimers --- liposomes --- thiophene --- angiogenesis --- micelles --- HSA oxidation --- platinum(IV) --- imaging --- chromatographic lipophilicity parameter --- amidophosphine --- copper and iron chelators in cancer --- Log P --- biomacromolecules --- bones --- DNA cleavage --- stopped-flow spectroscopy --- silver --- phosphonates --- transmetalation --- metallomics --- MRI --- fluorescence quenching --- partition coefficient --- gold fingers --- anticancer --- HSA binding --- gold --- ?0 --- targeting --- metastasis --- DNA interaction --- antimigration --- cytotoxicity --- HPLC --- ruthenium complexes --- zinc finger proteins --- Gold(III) complexes --- aquaporins --- antiproliferative --- protein-DNA recognition --- photoactivation --- lipophilicity --- cancer --- 1-methylcytosine --- PET --- ?-? stacking --- oxindolimine-metal complexes