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Gene Expression Systems: Using Nature for the Art of Expression offers detailed information on a wide variety of gene expression systems from an array of organisms. It describes several different types of expression systems including transient, stable, viral, and transgenic systems. Each chapter is written by a leader in the field. The book includes timelines and examples for each expression system, and provides an overview of the future of recombinant protein expression.Key Features* Provides detailed information on expression systems* Covers a variety of promoters and

Gene expression. --- Prokaryotes --- Insects --- Transgenic animals --- Eukaryotic cells. --- Genetics.

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"Offers a comprehensive examination of key advances in mouse genetic models throughout the twentieth century Features modern case studies connecting historic research to ongoing advances Authored by a thought-leader in the field"--

Mice --- Transgenic mice --- Genetic engineering --- History --- Transgenic animals --- House mice --- House mouse --- Mouse --- Mus musculus --- Rodents --- Transgenic mice. --- 1900-1999

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Mice --- Transgenic mice --- Mice as laboratory animals --- Laboratory animals --- Transgenic animals --- House mice --- House mouse --- Mouse --- Mus musculus --- Rodents --- Genetics --- Breeding

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Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, as well as speech disorders, and disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Timely introductory articles debate the alleged continuity of species of human and infrahuman behavior (Darwin), the utility of infrahuman animals in understanding human behavior and psychiatric disease, and the suitability of nonhuman models of complex neuropsychiatric dysfunctions involving language. Comprehensive and systematic, Transgenic and Knockout Models of Neuropsychiatric Disorders offers a clear assessment of whether genetic abnormalities produced from infrahuman models manifest the neuropsychiatric disorders to which they correspond in humans and how best they may be used to carry out successful research today.

Mental illness --- Transgenic mice --- Animal models. --- Genetic aspects. --- Genetics. --- Mice --- Transgenic animals --- Psychology, Pathological --- Animal psychopathology --- Comparative psychiatry --- Animal models --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system

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Recently, the first "zoopharming" product has reached market approval: it is a recombinant human protein for medical use that is produced in the milk of transgenic goats. In addition, other transgenic animals, including faster-growing salmon and „environmentally friendly" pigs with reduced levels of phosphate in their faeces are awaiting regulatory approval. These are only some examples of upcoming applications of genetic engineering in farm animals. Other potential applications include traditional breeding goals such as higher milk or meat yields, leaner meat, and disease resistance. While genetic engineering in livestock opens a huge range of possibilities, it also brings about concerns of safety and justification: does genetic engineering affect animal welfare? Is it safe and morally acceptable to apply genetic engineering to farm animals for the various purposes that are envisaged? It is against this background that the Europäische Akademie GmbH and the Berlin-Brandenburgische Akademie der Wissenschaften addressed the topic of transgenic farm animals in an interdisciplinary symposium in 2007. In these proceedings the following topics are covered: an analysis of the state of the art of the technology and its applications, an introduction to the specific application zoopharming (including its historical industrial development and the market for biopharmaceuticals), an assessment of ethical aspects, and considerations regarding the investigation of animal welfare implications of livestock biotechnology. The proceedings address science, industry, politics and the general public interested in the chances and risks of this upcoming field of biotechnology.

Transgenic animals. --- Livestock --- Transgenic animals --- Genetic engineering --- Animal biotechnology --- Genetics --- Biomedical Engineering --- Health & Biological Sciences --- Biology --- Moral and ethical aspects --- Genetic engineering. --- Biomedical engineering. --- Animal genetics. --- Ethics. --- Biotechnology. --- Biomedical Engineering. --- Animal Genetics and Genomics. --- Animal genetic engineering --- Biomedical Engineering and Bioengineering. --- Chemical engineering --- Deontology --- Ethics, Primitive --- Ethology --- Moral philosophy --- Morality --- Morals --- Philosophy, Moral --- Science, Moral --- Philosophy --- Values --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine