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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
vascular remodeling --- Smooth Muscle Cell --- endothelial cell --- hypoxia --- Fibrosis --- pulmonary arterial hypertension --- Mitochondria --- Bleomycin --- Inflammation --- Iron
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Acute inflammation is a highly regulated process, and its dysregulation can lead to the development of a chronic inflammatory state which is believed to play a main role in the pathogenesis of many diseases, including cancer. In recent years, the need to find new anti-inflammatory molecules has raised the scientific community´s interest for marine natural products. In this regard, the marine environment represents a source for isolating a wealth of bioactive compounds. In this Special Issue, the reported products have been obtained from microalgae, sea cucumber, octopus, squid, red alga-derived fungus, cnidarians, hard-shelled mussel, and sponges.
Tropical Eastern Pacific --- Zoanthus pulchellus --- critical illness --- zoanthamine --- SPR analysis --- dendritic cells --- endothelial cell death --- T cell differentiation --- seafood waste --- microalgae --- pyrogallol-phloroglucinol-6 --- NRLP3 --- THP-1 macrophages --- fucoxanthin --- photo-protection --- cytokine --- thromboxane --- Isochrysis galbana --- fish oil --- photoprotection --- functional ingredients --- rosmarinic acid --- MAPK --- marine invertebrates --- poor blood circulation --- anti-inflammatory activity --- eicosapentaenoic acid --- anti-oxidative --- macroalgae --- colon inflammation --- MGDG --- TLR4 --- 6-bieckol --- polyunsaturated fatty acid --- matrix metalloproteinases-9 (MMP-9) --- acute sickness behavior --- UVB --- eicosanoid --- clavulones --- carotenoids --- denervation --- polyunsaturated fatty acids --- skin --- epidermal hyperplasia --- Geodia barretti --- omega-3 --- parenteral nutrition --- inflammation --- ultraviolet B --- docosahexaenoic acid --- signal transducer and activator of transcription 3 (STAT3) --- anti-inflammatory --- zoantharia --- vascular smooth muscle cell proliferation and migration --- bioactive molecules --- polysaccharides --- lipopolysaccharide (LPS) --- glycolipids --- DSS colitis --- punaglandins --- marine nutraceuticals --- marine vertebrates --- phlorotannins --- acute lung injury (ALI) --- NF-?B --- diatoms --- interleukin (IL) --- inflammasome --- Frondanol --- Cucumaria frondosa --- prostaglandins --- Ecklonia cava --- 6-bromoindole --- NO inhibition --- surgery
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Asthma is a common complex and heterogeneous respiratory disease with an increasing prevalence in developed countries. Asthma is a disease consisting of different phenotypes that are driven by different mechanistic pathways (endotypes). The recognition of these phenotypes and endotypes is central to asthma management entailing prognostic and therapeutic implications. It is acknowledged that despite optimal treatment, many patients are poorly controlled, highlighting the need for phenotype-guided treatments. In this context, the emergence of novel therapies (monoclonal antibody therapy, bronchial thermoplasty) is paving the way for personalized asthma therapy. A better understanding of disease pathogenesis may enable the identification of biomarkers, mediators, novel therapeutic targets, and treatable traits. Further molecular phenotyping or endotyping of asthma will be necessary to tailor new therapeutic strategies. The present Special Issue on Asthma aims to provide the current knowledge on phenotypes and endotypes in appreciating and managing the heterogeneous condition that is asthma.
asthma --- lactic acidosis --- hyperchloremic acidosis --- hypocapnia --- hypercapnia --- wheezing --- bronchial biopsies --- symptom persistence --- clinical remission --- eosinophil --- adhesion --- viability --- proliferation --- airway smooth muscle cell --- pulmonary fibroblast --- phenotype --- acute severe asthma exacerbation --- near fatal asthma --- severe asthma --- inflammation --- interleukin-5 (IL-5) --- anti-IL-5 --- interleukin-4 --- airway remodeling --- matrix metalloproteinases-9 --- tissue inhibitor of metalloproteinase-1 --- alveolar macrophages --- lung function --- bronchodilation --- resistance --- obstruction --- reproducible --- spirometry --- obstructive sleep apnea --- bronchial asthma --- alternative overlap syndrome --- exacerbation --- reactive oxygen species --- PBMC --- mitochondrial function --- innate immunity --- immune regulation --- NLRP3 --- IL-1β --- allergic airway inflammation --- microbiome --- pathogenesis --- immune responses --- PreDicta --- preschool --- FeNO --- asthma-specific quality of life --- chronic rhinitis --- disease-specific quality of life --- health-related quality of Life (HRQLQ) --- children --- longitudinal study
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