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The major aim of this book is to de-mystify splenic pathology for non-specialist consultants and trainees in histopathology. The interpretation of pathological changes in the human spleen provides a significant challenge to the skills of even the most highly trained histopathologists. This comprehensive account of the most important and frequently encountered pathological conditions affecting the spleen is highly illustrated in colour throughout with numerous detailed macroscopic and microscopic specimens. Emphasis is placed upon the importance of adequate clinical information and technical preparation of splenectomy specimens in obtaining the best possible histopathological assessment of the tissue. A systematic, analytical approach to interpretation of pathological changes is used throughout the book. This should enable readers to feel confident in their assessment of significant processes within the spleen. This volume serves as an illustrated atlas, a bench manual, as a text, and as a source of reference, and will be an indispensable guide.

Spleen --- Hematopoietic system --- Lymphoid tissue --- Histopathology.

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Georges Köhler (1946-1995) was one of the most prominent German scientists of recent history. In 1984, at an age of 38, he received the Nobel Prize in Physiology or Medicine, together with N.K. Jerne and C. Milstein, for inventing the technique for generating monoclonal antibodies. This method and its subsequent applications had an enormous impact on basic research, medicine and the biotech industry. In the same year, Köhler became one of the directors of the Max-Planck-Institute of Immunobiology in Freiburg; his unfortunate premature death in 1995 set an end to his extraordinary career. Prof. Klaus Eichmann, who had joined the institute as director in 1981, and had invited Köhler to become his codirector, is one of the people who were closest to Georges Köhler. This scientific biography commemorates the 10th anniversary of Köhler's untimely death. It describes his scientific and personal biography, based on 10 years of close personal and professional relationship between Eichmann and Köhler, as well as interviews with many colleagues and friends, including his "Doktorvater" and mentor Fritz Melchers. Köhler's scientific achievements are explained in a way to make them understandable for the general public and discussed in the historical context of the immunological research at the time.

Immunologists --- Hybridomas. --- Monoclonal antibodies. --- Köhler, Georges. --- Antibodies, Monoclonal --- Monoclonal immunoglobulins --- Immunoglobulins --- Molecular cloning --- Myeloma-spleen cell hybrids --- Clone cells --- Lymphocytes --- Monoclonal antibodies --- Plasmacytoma --- Somatic hybrids --- Immunology --- Medical scientists --- Immunology. --- Medicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Immunobiology --- Serology --- Health Workforce --- Biomedicine, general. --- Köhler, Georges --- Kohler, Georges.

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The spleen is an organ which has diverse functions including immunologic and hematologic. The Atlas of Spleen Pathology describes and selectively illustrates the normal and pathologic conditions that afflict the spleen. This extraordinary collection of high quality digital images will materially aid in continuing efforts to recognize, understand, and accurately interpret the gross and light microscopic findings in spleens.

Bone marrow -- Diseases. --- Histology, Pathological -- Atlases. --- Histology. --- Pathology -- Atlases. --- Lymphoid Tissue --- Tissues --- Lymphatic System --- Immune System --- Anatomy --- Hemic and Immune Systems --- Spleen --- Medicine --- Health & Biological Sciences --- Hematologic Diseases --- Pathology --- Diseases --- Medicine. --- Pathology. --- Medicine & Public Health. --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Hematopoietic system --- Lymphoid tissue

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Image analysis can be applied to rich and assorted scenarios; therefore, the aim of this recent research field is not only to mimic the human vision system. Image analysis is the main methods that computers are using today, and there is body of knowledge that they will be able to manage in a totally unsupervised manner in future, thanks to their artificial intelligence. The articles published in the book clearly show such a future.

Newton-Raphson’s method --- chaos --- image encryption/decryption --- security analysis --- image encryption --- cryptanalysis --- hyper-chaotic --- ribonucleic acid --- color image encryption --- transformed Zigzag --- image segmentation --- computer-assisted diagnosis --- machine learning --- spleen injury detection --- hyperchaotic --- permutation --- diffusion --- multiple bit operation --- circular-step wedge --- contrast-detail --- mutual information --- visible ratio --- anode heel effect --- prior information --- entropy --- fwi --- regularization --- inverse problems --- bat optimization --- human crowd behavior (HCB) --- improved entropy (IE) --- Jaccard similarity --- multi-person counting --- particles gradient motion (PGM) --- speeded up robust features (SURF) --- Retinex --- image enhancement --- gamma correction --- low-light image --- HSV color space --- scan route --- Hilbert curve --- run-length-based entropy coding --- image and video compression --- secure communication --- cellular neural network --- power-divergence measure --- computed tomography --- iterative reconstruction --- maximum-likelihood expectation-maximization method --- continuous-time image reconstruction --- n/a --- Newton-Raphson's method

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This book provides a comprehensive and up-to-date overview of the pathologic features of common benign and malignant hematopoietic disorders in spleen and liver for practicing pathologists, hematopathologists and clinicians. The authors are from large academic centers, affiliated teaching hospitals and central referral clinics and are experienced in the diagnosis of hematopoietic disorders in the spleen and liver. The book consists of 21 chapters, with the first three chapters devoted to normal histologic features, conventional, cytogenetic and molecular studies necessary for the diagnosis of hematopoietic disorders in the spleen and liver. Chapters 4 to 17 cover the primary and secondary mature B- and T/NK cell lymphomas, Hodgkin lymphoma, B and T cell lymphoblastic leukemias, myeloid neoplasms, histiocytic and dendritic neoplasms, and post-transplant disorders including post transplant lymphoproliferative disorders. Chapters 19 to 21 encompass red blood cell disorders, other benign hematologic disorders and infectious/inflammatory disorders that could mimic hematopoietic neoplasms. These chapters are formatted on specific hematopoietic neoplasms to comprise epidemiology, etiology, pathogenesis, morphology, immunophenotyping, molecular genetics, prognosis and brief treatment guidelines. Diagnostic caveats are included in order to have a quick review of the key points in each chapter. Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver covers most, if not all of the benign and malignant hematopoietic disorders in the spleen and liver and serves as a practical and useful resource for general pathologists and hematopathologists.

Hematopoietic system. --- Hemopoietic system --- Hematopoiesis --- Hematopoietic System. --- Leukemia. --- Lymphoma. --- Neoplasms, Plasma Cell. --- Liver Diseases. --- Spleen. --- Hematopoietic Systems --- System, Hematopoietic --- Liver Dysfunction --- Disease, Liver --- Diseases, Liver --- Dysfunction, Liver --- Dysfunctions, Liver --- Liver Disease --- Liver Dysfunctions --- Plasma Cell Neoplasms --- Neoplasm, Plasma Cell --- Plasma Cell Neoplasm --- Germinoblastoma --- Lymphoma, Malignant --- Reticulolymphosarcoma --- Sarcoma, Germinoblastic --- Germinoblastic Sarcoma --- Germinoblastic Sarcomas --- Germinoblastomas --- Lymphomas --- Lymphomas, Malignant --- Malignant Lymphoma --- Malignant Lymphomas --- Reticulolymphosarcomas --- Sarcomas, Germinoblastic --- Lymphatic Diseases --- Hematologic Neoplasms --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Myeloproliferative Disorders --- Pathology. --- Hematology. --- Oncology  . --- Oncology. --- Tumors --- Haematology --- Internal medicine --- Blood --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Malalties hematològiques --- Malalties del sistema limfàtic --- Melsa --- Fetge --- Diagnòstic. --- Oncologia --- Medicina --- Oncologia geriàtrica --- Oncologia pediàtrica --- Oncologia veterinària --- Càncer --- Infermeria oncològica --- Diagnosi --- Diagnòstic físic --- Examen mèdic (Diagnòstic) --- Exploració médica (Diagnòstic) --- Exploració clínica (Diagnòstic) --- Medicina clínica --- Cateterisme --- Cribratge --- Diagnòstic d'infermeria --- Diagnòstic diferencial --- Diagnòstic dual --- Diagnòstic molecular --- Diagnòstic prenatal --- Diagnòstic quirúrgic --- Diagnòstic per la imatge --- Electrodiagnòstic --- Entrevista clínica --- Examen físic --- Isòtops radioactius en diagnòstic mèdic --- Monitoratge de pacients --- Proves funcionals (Medicina) --- Patologia --- Pronòstic mèdic --- Símptomes --- Abdomen --- Aparell digestiu --- Tracte biliar --- Cèl·lules hepàtiques --- Bilis --- Cirurgia hepàtica --- Hepatologia --- Sistema limfàtic --- Elefantiasi --- Limfomes --- Malalties de la sang --- Malalties sanguínies --- Malalties --- Anèmia --- Eosinofília --- Mononucleosi --- Septicèmia --- Trastorns de les plaquetes sanguínies --- Hematologia