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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

metacognitive therapy --- S-REF model --- metacognition --- psychological disorders --- causal mechanisms

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Libraries are places of learning and knowledge creation. Over the last two decades, digital technology—and the changes that came with it—have accelerated this transformation to a point where evolution starts to become a revolution.The wider Open Science movement, and Open Access in particular, is one of these changes and is already having a profound impact. Under the subscription model, the role of libraries was to buy or license content on behalf of their users and then act as gatekeepers to regulate access on behalf of rights holders. In a world where all research is open, the role of the library is shifting from licensing and disseminating to facilitating and supporting the publishing process itself.This requires a fundamental shift in terms of structures, tasks, and skills. It also changes the idea of a library’s collection. Under the subscription model, contemporary collections largely equal content bought from publishers. Under an open model, the collection is more likely to be the content created by the users of the library (researchers, staff, students, etc.), content that is now curated by the library.Instead of selecting external content, libraries have to understand the content created by their own users and help them to make it publicly available—be it through a local repository, payment of article processing charges, or through advice and guidance. Arguably, this is an overly simplified model that leaves aside special collections and other areas. Even so, it highlights the changes that research libraries are undergoing, changes that are likely to accelerate as a result of initiatives such as Plan S.This Special Issue investigates some of the changes in today’s library services that relate to open access.

open access --- CERN --- journal flipping --- publication fee --- research support --- repositories --- service portfolio --- publishing --- publishing literacy --- researcher engagement --- workflow --- sociology of science --- journal subscription --- monitoring --- journals --- information services --- library-mediated deposit --- offsetting --- Open Access --- monographs --- scholarly communication --- particle physics --- scholarly communications --- Research Excellence Framework --- research information systems --- training --- research support services --- library --- humanities --- social media --- open science --- research libraries --- staff --- transition --- vocational education and training research --- REF 2021 --- marketing --- SCOAP3 --- APC --- UK funder policies --- compliance --- social sciences --- gold open access --- research information

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Tort and negligence --- ziekenhuizen --- Medical law --- Hygiene. Public health. Protection --- aansprakelijkheid (recht) --- Belgium --- Assurances --- Burgerlijk recht --- Droit civil --- Gezondheidszorg --- Hôpitaux --- Soins de santé --- Verzekeringen --- Ziekenhuiswezen --- Torts --- Criminal liability --- Tort liability of hospitals --- Physicians --- Physicians' malpractice insurance --- Responsabilité civile --- Responsabilité pénale --- Médecins --- Assurance de responsabilité médicale --- Malpractice --- Responsabilité professionnelle --- 351.84*7 <493> --- 347.56 <493> --- 342.7-056.24 <493> --- 347.51 <493> --- 347.56:614.256 <493> --- 364.444.046 <493> --- 614.253.8 <493> --- REF --- aansprakelijkheid --- gezondheidszorg België --- ziekenhuis --- 601.7 --- gezondheidsrecht --- recht --- 05.04.b --- 13.12 --- Medisch recht. Gezondheidsrecht. Wetgeving i.v.m. ziekenhuizen--België --- Beroepsaansprakelijkheid. Beroepsmatige aansprakelijkheid--België --- Gezondheidsrecht --- Aansprakelijkheidsverzekering ; Beroeps- en bedrijfsaansprakelijkheid --- Wettelijke en contractuele aansprakelijkheid ; Geneesheren ; Veeartsen ; Apothekers ; Tandartsen ; Paramedici --- 347.56 <493> Beroepsaansprakelijkheid. Beroepsmatige aansprakelijkheid--België --- 351.84*7 <493> Medisch recht. Gezondheidsrecht. Wetgeving i.v.m. ziekenhuizen--België --- Responsabilité civile --- Responsabilité pénale --- Hôpitaux --- Médecins --- Assurance de responsabilité médicale --- Responsabilité professionnelle

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Dear colleagues, This Special Issue, “Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches”, focuses on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular disorders or tumors, and novel therapeutic approaches for endothelial dysfunctions. Vascular endothelium is an active tissue and plays a crucial role in the maintenance of vascular homeostasis. Chronic exposure to risk factors, such as hypertension, high cholesterolemia, or oxidative stress, induces endothelial dysfunctions and results in a loss of endothelial integrity, smooth muscle cell proliferation, and macrophage recruitment. The pathophysiology of endothelial dysfunction (ED) is complex and multi-factorial factors are involved, such as oxidative stress or chronic inflammation. The primary prevention of cardiovascular risk factors and endothelial dysfunctions, as well as the early detection of or molecular imaging techniques for endothelial dysfunction, helps to prevent the development of cardiovascular disorders. Novel therapeutic approaches or drug delivery systems for endothelial dysfunctions have had promising beneficial effects in preclinical or clinical levels by affecting the progression of atherosclerotic changes, tumor angiogenesis, and host–immune reactions near tumor environments.

endothelial cells --- oxidative stress --- inflammageing --- endothelial dysfunction --- aldehyde dehydrogenase-2 --- cardiovascular disease --- neurovascular disease --- vascular inflammation --- APE1/Ref-1 --- cardiovascular diseases --- subcellular localization --- serological biomarkers --- atherosclerosis --- aerobic exercise --- PCSK9 --- LOX-1 --- insulin resistance --- macrophage polarity --- serum γ-glutamyltransferase --- essential hypertension --- cardiovascular risk factors --- angiogenesis --- nargenicin A1 --- compound 9 --- VEGF --- VEGFR2 --- HIF-1α --- electronegative low-density lipoprotein --- LDL(–) --- L5 LDL --- oxidized LDL --- oxLDL --- ADMA --- arginine --- arginine paradox --- BH4 --- blood pressure --- COVID-19 --- dietary supplements --- endothelium --- eNOS uncoupling --- heart failure --- hypertension --- L-arginine --- myocardial infarction --- NADPH --- nitric oxide --- peripheral artery disease --- ApoE knockout mouse --- atorvastatin --- VCAM-1 --- galectin-3 --- neutrophil/lymphocyte ratio --- electronegative LDL --- LDL(−) --- lectin-like oxLDL receptor-1 --- dyslipidemia --- chronic venous insufficiency --- prolyl oligopeptidase (POP) --- inflammation --- endothelial disfunction --- lung disease --- endothelial to mesenchymal transition --- pulmonary hypertension --- pulmonary fibrosis --- metformin --- diabetes --- CV risk --- hyperglycemia --- glycated lipoproteins --- glycated LDL --- glycated HDL --- endothelial cell dysfunction --- molecular mechanisms --- epigenetic factors --- therapeutic approaches --- vasoactive factors --- EndoMT --- TGF-β --- epigenetics --- endothelial cell --- glycolysis --- metabolism --- pathological angiogenesis --- tumor microenvironment --- MRI (magnetic resonance imaging) --- high-fat diets --- plaque burden --- low-level laser therapy --- phototherapy --- vascular disease --- healing --- ischemia --- vascular calcification --- chronic kidney disease --- CKD --- uremic toxins --- hyperphosphatemia --- vascular smooth muscle cells --- VSMCs --- macrophages --- n/a --- LDL(-)