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For thousands of years, pharmacological knowledge coming from natural remedies, has been handed down from generation to generation, without any awareness of the ways in which preparations are made to face diseases. The advent of pharmaceutical chemistry and of the modern drug industry turned that lack of awareness into a scientific knowledge that changed the destiny of the human race. The twenty-eight chapters of this book, are taken from the lectures held by Professor Ettore Novellino every year in his course “Pharmaceutical Chemistry and Toxicology 2”. The first chapters address the basic notions of drugs, homeostasis, pharmacopoeia, and receptor; then, the different pharmaceutical classes are introduced by analyzing their pharmacological and chemical aspects. In particular, the structural study of the interaction between drugs and receptors or biological enzymes gives the fundamentals to connect the chemical and stereochemical properties of a compound family, with the biological activity, a correlation better known as Quantitative Structure-Activity Relationship (QSAR). Several examples of the synthesis of some of the most historically renown drugs, provided at the end of each chapter, integrate the book.

Metabotropic receptor --- Pharmaceutical Chemistry --- Quantitative Structure-Activity Relationship

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QSAR in Safety Evaluation and Risk Assessment provides comprehensive coverage on QSAR methods, tools, data sources, and models focusing on applications in products safety evaluation and chemicals risk assessment. Organized into five parts, the book covers almost all aspects of QSAR modeling and application. Topics in the book include methods of QSAR, from both scientific and regulatory viewpoints; data sources available for facilitating QSAR models development; software tools for QSAR development; and QSAR models developed for assisting safety evaluation and risk assessment. Chapter contributors are authored by a lineup of active scientists in this field. The chapters not only provide professional level technical summarizations but also cover introductory descriptions for all aspects of QSAR for safety evaluation and risk assessment.

Drugs --- QSAR (Biochemistry) --- Quantitative structure-activity relationships (Biochemistry) --- Structure-activity relationships (Biochemistry) --- Structure-activity relationship (Pharmacology) --- Pharmaceutical chemistry --- Pharmacology --- Structure-activity relationships. --- Quantitative Structure-Activity Relationship --- Consumer Product Safety --- Environmental Pollutants --- Toxicity Tests

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Chemistry --- QSAR (Biochemistry) --- Structure-activity relationships (Biochemistry) --- Drugs --- Quantitative Structure-Activity Relationship. --- Combinatorial Chemistry Techniques. --- Biology. --- Pharmacology. --- Relations structure-activité quantitatives (Biochimie) --- Relations structure-activité (Biochimie) --- Médicaments --- Structure-activity relationships --- Relations structure-activité --- Structure-activity relationships. --- Health Sciences --- Life Sciences --- Biochemistry --- Pharmacy and Pharmacology --- Biochemorphology --- Biomolecules --- Chemical structure-biological activity relationships --- Relationships, Structure-activity (Biochemistry) --- Quantitative structure-activity relationships (Biochemistry) --- Structure-activity relationship (Pharmacology) --- Pharmacologies --- Pharmaceutical Preparations --- Chemistry Technic, Combinatorial --- Chemistry Technics, Combinatorial --- Chemistry Technique, Combinatorial --- Combinatorial Chemistry Technic --- Combinatorial Chemistry Technics --- Combinatorial Chemistry Technique --- Technic, Combinatorial Chemistry --- Technics, Combinatorial Chemistry --- Technique, Combinatorial Chemistry --- Chemistry Techniques, Combinatorial --- Techniques, Combinatorial Chemistry --- 3D-QSAR --- QSAR --- QSPR Modeling --- Quantitative Structure Property Relationship --- Structure Activity Relationship, Quantitative --- 3D QSAR --- 3D-QSARs --- Modeling, QSPR --- Quantitative Structure Activity Relationship --- Quantitative Structure-Activity Relationships --- Relationship, Quantitative Structure-Activity --- Relationships, Quantitative Structure-Activity --- Structure-Activity Relationship, Quantitative --- Structure-Activity Relationships, Quantitative --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- pharmacology --- Physical biochemistry --- Pharmaceutical chemistry --- Pharmacology --- Gene Library --- Peptide Library --- Oligonucleotide Array Sequence Analysis --- High-Throughput Screening Assays --- Click Chemistry --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacy --- Pharmacy, Therapeutics, & Pharmacology

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Heterocyclic Compounds --- Quantitative Structure-Activity Relationship. --- Drug Design. --- Models, Molecular. --- Pharmaceutical Preparations --- QSAR (Biochemistry) --- Drugs --- Relations structure-activité quantitatives (Biochimie) --- Médicaments --- chemistry. --- Design. --- Conception --- Chemistry. --- Chemistry, Organic. --- Biochemistry. --- Organic Chemistry. --- Medicinal Chemistry. --- Computer Applications in Chemistry. --- Biochemistry, general. --- Heterocyclic compounds --- Drug Design --- Quantitative Structure-Activity Relationship --- Models, Molecular --- Models, Theoretical --- Chemicals and Drugs --- Structure-Activity Relationship --- Drug Discovery --- Chemistry, Pharmaceutical --- Investigative Techniques --- Biochemical Phenomena --- Pharmacological Phenomena --- Chemistry --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Phenomena --- Physiological Phenomena --- Pharmacology --- Phenomena and Processes --- Biological Science Disciplines --- Natural Science Disciplines --- Disciplines and Occupations --- Pharmacy, Therapeutics, & Pharmacology --- Biochemistry --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Design --- Structure-activity relationships --- Organic chemistry --- Pharmacologies --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Physiological Processes --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Chemical Processes --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Pharmacologic Phenomena --- Pharmacologic Phenomenon --- Pharmacologic Process --- Pharmacological Concepts --- Pharmacological Phenomenon --- Pharmacologic Processes --- Pharmacological Processes --- Concept, Pharmacological --- Concepts, Pharmacological --- Pharmacological Concept --- Phenomena, Pharmacologic --- Phenomena, Pharmacological --- Phenomenon, Pharmacologic --- Phenomenon, Pharmacological --- Process, Pharmacologic --- Processes, Pharmacologic --- Processes, Pharmacological --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Processes --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Chemistry, Pharmaceutic --- Pharmaceutic Chemistry --- Pharmaceutical Chemistry --- Medicinal Chemistry --- Chemistry, Medicinal --- Drug Prospecting --- Discovery, Drug --- Prospecting, Drug --- Relationship, Structure-Activity --- Relationships, Structure-Activity --- Structure Activity Relationship --- Structure-Activity Relationships --- Experimental Model --- Experimental Models --- Mathematical Model --- Model, Experimental --- Models (Theoretical) --- Models, Experimental --- Models, Theoretic --- Theoretical Study --- Mathematical Models --- Model (Theoretical) --- Model, Mathematical --- Model, Theoretical --- Models, Mathematical --- Studies, Theoretical --- Study, Theoretical --- Theoretical Model --- Theoretical Models --- Theoretical Studies --- Molecular Models --- Model, Molecular --- Molecular Model --- 3D-QSAR --- QSAR --- QSPR Modeling --- Quantitative Structure Property Relationship --- Structure Activity Relationship, Quantitative --- 3D QSAR --- 3D-QSARs --- Modeling, QSPR --- Quantitative Structure Activity Relationship --- Quantitative Structure-Activity Relationships --- Relationship, Quantitative Structure-Activity --- Relationships, Quantitative Structure-Activity --- Structure-Activity Relationship, Quantitative --- Structure-Activity Relationships, Quantitative --- Pharmaceutic Preparations --- Pharmaceutical Products --- Preparations, Pharmaceutical --- Preparations, Pharmaceutic --- Products, Pharmaceutical --- Drug Modeling --- Design, Drug --- Designs, Drug --- Drug Designs --- Drug Modelings --- Modeling, Drug --- Modelings, Drug --- Compounds, Heterocyclic --- Cycloids, Mixed (Chemistry) --- Heteroatomic compounds --- Heterocycles --- Mixed cycloids (Chemistry) --- Structure-activity relationship (Pharmacology) --- Quantitative structure-activity relationships (Biochemistry) --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- pharmacology --- Composition --- Organic chemistry. --- Chemoinformatics. --- Medicinal chemistry. --- Physical sciences --- Biology --- Medical sciences --- Chemical informatics --- Chemiinformatics --- Chemoinformatics --- Chemistry informatics --- Information science --- Computational chemistry --- Chemistry, Medical and pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Data processing