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Post-Translational Modifications (PTMs) may occur at any stage following the translation process in the lifecycle of specific proteins. PTMs regulate several cellular processes including protein stability, subcellular localization, and protein-protein interactions. In recent years, more and more target proteins of PTMs have been proved to be related to epigenetic regulation and cell fate. Some enzymes that catalyze PTMs have also been found to be involved in human diseases. This book intends to provide the reader with an overview of the current state of the art in this research field, which focuses on the recent advances, new findings and perspectives in cellular functions, and their clinical significance in human diseases. We hope this book will help researchers in this area.

Cell metabolism. --- Post-translational modification.

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Post - Translational Modification: A Practical Approach and its companion volume Protein Expression: A Practical Approach form the final part of the PAS mini-series on protein synthesis and processing. This volume begins with a chapter on protein sequencing followed by a chapter on protein folding and import into organelles. The next three chapters cover the three major forms of covalent modification: phosphorylation, glycosylation, and lipid modification. Proteolytic processing the is the next topic and the final two chapters are concerned with protein turnover in mammalian cells and yeast. This book is a comprehensive volume of the best current methodology and is designed to be used at the bench or away from the bench to gain insight into future experimental approached.

Genetics --- Biology --- Health & Biological Sciences --- Post-translational modification

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This book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific gene expression patterns. Several examples from lymphoid and myeloid lineages are given as well as particular examples of leukemia fusion proteins that contain a part of a transcription factor. In the given chapters covering each one particular example, the function of transcription factors is characterized in normal as well as leukemic contexts. New technologies such as ChIP-Seq or RNA-Seq, that make use of genome-wide sequencing, have shown that such master regulators of blood cell development often work in combinatorial fashion and, when dysregulated, results in leukemogenesis. This book is not only intended for experts but it should also be a useful resource for younger scientists or scientists from other disciplines, who may use this book as a stimulating starting point for further discoveries and/ or translational endeavors.

Genetic transcription. --- Cytology. --- Post-translational modification. --- Hematopoietic system. --- Developmental biology. --- Gene Transcription. --- Cell Biology. --- Post-translational Modifications. --- Haematopoietic System. --- Developmental Biology and Stem Cells.

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This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena. Among the highlights are chapter-length discussion of such topics as:  how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.  .

Biomedicine. --- Biomedicine general. --- Geriatrics/Gerontology. --- Cell Biology. --- Clinical Nutrition. --- Aging. --- Posttranslational Modification. --- Medicine. --- Geriatrics. --- Personal health and hygiene. --- Post-translational modification of proteins. --- Cytology. --- Aging --- Médecine --- Gériatrie --- Cytologie --- Vieillissement --- Research. --- Recherche --- Aging_xResearch. --- Post-translational modification. --- Epigenetics. --- Nutrition. --- Health aspects. --- Alimentation --- Food --- Nutrition --- Age --- Ageing --- Senescence --- Health aspects --- Physiological effect --- Clinical nutrition. --- Posttranslational modification. --- Cell biology. --- Health --- Physiology --- Diet --- Dietetics --- Digestion --- Food habits --- Malnutrition --- Genetics --- Developmental biology --- Gerontology --- Longevity --- Age factors in disease --- Post-translational modification . --- Co-translational modification --- Cotranslational modification --- Modification, Post-translational --- Post-translation protein modification --- Post-translational protein modification --- Posttranslation protein modification --- Posttranslational modification --- Posttranslational protein modification --- Genetic translation --- Proteins --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Medicine --- Older people --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Synthesis --- Diseases --- Health and hygiene --- Biomedicine, general. --- Clinical nutrition --- Diet and disease --- Dietotherapy --- Medical nutrition therapy --- MNT (Medical nutrition therapy) --- Nutrition therapy --- Therapeutics, Physiological --- Health Workforce --- Therapeutic use --- Biomedical Research. --- Ageing. --- Post-translational Modifications. --- Biological research --- Biomedical research

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This volume focusses on oxidative modifications of lipid molecules and the successive generation of singlet oxygen. The book also covers the secondary adductions of these reactive species with proteins and aminophospholipids. During lipid peroxidation, the initial event is the formation of lipid hydroperoxide, which is followed by an oxidation event that starts a chain-reaction. The formed lipid hydroperoxide gradually decomposes into harmful aldehydes, which are the advanced end-products of lipid peroxidation. The book consists of three sections:   Part I, entitled Lipid peroxidation and small molecule adducts focusses on the biochemical events that are involved in lipid peroxidation and to the formation of small molecules like singlet molecular oxygen. This part of the book also introduces the hexanoyl-lysine adduct. Part II, entitled Pathophysiological consequences covers a range of damaging physiological consequences of lipid peroxidation, ranging from atherosclerosis to neurodegenerative disorders. Finally, Part III, entitled Applications for diagnosis and development of functional food looks into potential diagnostic uses of lipid peroxidation, the possible beneficial effects that can be achieved and new assays in food safely that have been developed.

Lipids --- Lipids. --- Peroxidation. --- Lipides --- Lipins --- Lipoids --- Medicine. --- Cancer research. --- Food --- Posttranslational modification. --- Biomedicine. --- Cancer Research. --- Posttranslational Modification. --- Food Science. --- Biotechnology. --- Biomolecules --- Steroids --- Oncology. --- Post-translational modification . --- Food science. --- Science --- Co-translational modification --- Cotranslational modification --- Modification, Post-translational --- Post-translation protein modification --- Post-translational protein modification --- Posttranslation protein modification --- Posttranslational modification --- Posttranslational protein modification --- Genetic translation --- Proteins --- Tumors --- Synthesis --- Food—Biotechnology. --- Cancer research