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This book covers the broad area related to Notch-mediated regulation of the immune system and tumorigenesis. Notch signaling was originally identified as a crucial pathway to regulate cell fate choice. Subsequent studies, however, have revealed that Notch regulates many steps of immune cell differentiation or development as well as tumorigenesis of cells. Although there are still many controversial issues regarding the functions or regulatory mechanism of Notch, it is important to summarize all data together in one volume to help facilitate this research area. Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors. Therefore, this book covering the broad area of Notch in immunology and tumorigenesis will be attractive to many researchers including faculty members and postdoctoral fellows in academia and researchers in the pharmaceutical industry.

Notch proteins. --- Medicine. --- Cancer research. --- Immunology. --- Biomedicine. --- Cancer Research. --- Membrane proteins --- Notch genes --- Oncology. --- Tumors --- Immunobiology --- Life sciences --- Serology --- Cancer research

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"The goal of this volume is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer. Experts in the field as well as scientists and health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for every clinician or scientist interested in the role of Notch signalling in embryology and cancer. We hope that this volume will be adopted as the standard text in this area of science and will stimulate new interest in the role of Notch signalling for embryology and cancer. We further hope that this compendium will serve as both a source for current researchers and a guide to stimulate and assist those in related disciplines to enter this exciting field of research"--Provided by publisher.

Cellular signal transduction. --- Neoplasms. --- Receptors, Notch. --- Receptors. --- Biochemical Processes --- Receptors, Cell Surface --- Diseases --- Transcription Factors --- Cell Physiological Processes --- Embryonic and Fetal Development --- Metabolic Phenomena --- Biological Science Disciplines --- Biochemical Phenomena --- Morphogenesis --- Natural Science Disciplines --- Membrane Proteins --- Phenomena and Processes --- Reproduction --- Cell Physiological Phenomena --- Chemical Processes --- Proteins --- Growth and Development --- Reproductive Physiological Processes --- Chemical Phenomena --- Disciplines and Occupations --- Amino Acids, Peptides, and Proteins --- Physiological Processes --- Reproductive Physiological Phenomena --- Chemicals and Drugs --- Physiological Phenomena --- Reproductive and Urinary Physiological Phenomena --- Embryonic Development --- Metabolism --- Physiology --- Neoplasms --- Receptors, Notch --- Signal Transduction --- Human Anatomy & Physiology --- Medicine --- Health & Biological Sciences --- Oncology --- Animal Biochemistry --- Notch proteins. --- Embryology. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Animal embryology --- Animals --- Development, Embryological --- Development, Embryonic --- Development, Zygotic --- Embryogenesis --- Embryogeny --- Embryological development --- Embryonic development --- Zoology --- Zygote development --- Zygotes --- Zygotic development --- Zygotic embryogenesis --- Embryology --- Development --- Medicine. --- Cancer research. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Developmental biology --- Morphology (Animals) --- Embryos --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Membrane proteins --- Notch genes --- Oncology. --- Cytology.