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Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume One: Biology and Pathophysiology provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This volume discusses topics such as tumor microenvironment in hepatocellular carcinoma, endoplasmic reticulum stress and unfolded protein response, effects of cirrhosis and hepatitis on the prognosis of HCC, mitochondrial metabolism, next generation sequencing, and telomerase. In addition, it discusses exosomes role in HCC progression, metastasis and chemokines.

Liver --- Hepatocellular carcinoma --- Cancer. --- Precision medicine. --- Liver Neoplasms --- Precision medicine

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Gallbladder --- Cancer. --- Liver --- Pancreas --- Liver Neoplasms --- Pancreatic Neoplasms --- Gallbladder Neoplasms --- Càncer de fetge --- Càncer de pàncrees --- Vesícula biliar

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This fifth volume of the series, Methods of Cancer Diagnosis, Therapy, and Prognosis, discusses in detail the diagnosis, treatment, and prognosis of Liver Cancer. Both standard and emerging therapies for this cancer, written by expert oncologists/pathologists in this field, are included. This fully illustrated volume: Is divided into 7 sections: Applications of Imaging, Resectable Liver Cancer, Unresectable Liver Cancer, Hepatocellular Cancer, Liver Colorectal Metastasis, Biliary Cancer, and Splenic Cancer. Discusses imaging modalities for diagnosis, treatment assessment, and prognosis. Includes descriptions of radial magnetic resonance imaging, helical computed tomography, magnetic resonance imaging, FDG-PET, contrast-enhanced sonography, multidetector-row computed tomography, and single photon emission computed tomography. Presents imaging methods for localized fibrous tumors of the liver, abdominal neoplasms, cholangiocarcinoma, gall bladder carcinoma, hepatic cellular carcinoma, extrahepatic disease, intrahepatic disease, focal liver lesions, biliary cystic tumors, extra hepatic bile duct carcinoma, and splenic metastases. Highlights methods for treatment of hepatocellular carcinoma (HCC) with thalidomide and transarterial treatment of hepatic malignancies. Discusses postoperative interferon alpha treatment of patients with HCC. Details the methods of immunohistochemistry, tissue microarray, and proteomic analysis for diagnosis and prognosis. The technological advances presented in this volume are expected to expedite new discoveries and their translation to clinical practice. The field of oncology will benefit the most from these advanced methods, as a combination of therapies and personalized medicine will improve early detection of liver cancer and other cancer types. Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.

Liver -- Cancer. --- Liver Neoplasms -- diagnosis. --- Liver Neoplasms -- therapy. --- Liver Neoplasms --- Neoplasm Metastasis --- Digestive System Neoplasms --- Neoplastic Processes --- Liver Diseases --- Digestive System Diseases --- Pathologic Processes --- Neoplasms by Site --- Neoplasms --- Diseases --- Pathological Conditions, Signs and Symptoms --- Oncology --- Medicine --- Health & Biological Sciences --- Oncology. --- Cancer --- Nursing. --- Liver --- Diagnosis. --- Prognosis. --- Treatment. --- Clinical nursing --- Nurses and nursing --- Nursing process --- Medicine. --- Cancer research. --- Radiotherapy. --- Surgical oncology. --- Biomedicine. --- Cancer Research. --- Surgical Oncology. --- Care of the sick --- Tumors --- Abdomen --- Biliary tract

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Liver Neoplasms --- Cancer of the Liver --- Cancer, Hepatocellular --- Hepatic Neoplasms --- Hepatocellular Cancer --- Neoplasms, Hepatic --- Neoplasms, Liver --- Cancer of Liver --- Hepatic Cancer --- Liver Cancer --- Cancer, Hepatic --- Cancer, Liver --- Cancers, Hepatic --- Cancers, Hepatocellular --- Cancers, Liver --- Hepatic Cancers --- Hepatic Neoplasm --- Hepatocellular Cancers --- Liver Cancers --- Liver Neoplasm --- Neoplasm, Hepatic --- Neoplasm, Liver --- Liver --- Liver Neoplasms. --- Cancer.

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The management of colorectal liver metastases has evolved rapidly over the last decade with the introduction of newer and effective chemotherapies and a redefinition for cure. These range from the philosophical (including the greater awareness of treatment with curative intent), through the practical (more aggressive definition of respectability for cure and the use of more effective chemotherapies for both palliation and as adjuncts to surgery), to the futuristic use of biological strategies (including monoclonal antibodies and gene therapies) and lastly to the pragmatic but equally important issues of health economics (who is going to foot the bill for these increasingly expensive treatment strategies). Liver metastases addresses the contemporary multidisciplinary management of liver metastases. Throughout the text, experience from the paradigms of colorectal cancer metastases treatment strategies are used to point to new directions in the management of liver metastases from other cancers. This book overviews current understanding of the biology of liver metastases, and reviews current methods of detection and diagnosis. Chapters offer objective and systematic reviews of each of the current major treatment modalities: surgical resection; destructive therapies; chemotherapy (systemic and regional); whether there is a role for radiotherapy; biological therapies (including hormone treatment antibodies and gene therapy); and lastly the decision-making strategies that must be employed for successful multidisciplinary management. Featuring state-of-the-art reviews, key points, treatment algorithms and clear, concise illustrations this book provides the ultimate companion to anyone interested or working in the area of liver disease. This book will appeal to consultant and trainee surgeons in general surgery, hepatobiliary surgery, upper GI surgery, colorectal surgery; consultant and trainee medical and clinical oncologists with an interest in liver tumours; and consultant and trainee radiologists with an interest in liver disease.

Colorectal Neoplasms -- Pathology. --- Liver metastasis -- Treatment. --- Liver Neoplasms -- Secondary. --- Liver Neoplasms -- Therapy. --- Liver metastasis --- Colorectal Neoplasms --- Liver Neoplasms --- Pathology --- Intestinal Neoplasms --- Liver Diseases --- Rectal Diseases --- Digestive System Neoplasms --- Colonic Diseases --- Medicine --- Health Occupations --- Intestinal Diseases --- Gastrointestinal Neoplasms --- Digestive System Diseases --- Neoplasms by Site --- Diseases --- Neoplasms --- Gastrointestinal Diseases --- Disciplines and Occupations --- Oncology --- Health & Biological Sciences --- Treatment --- Liver --- Treatment. --- Cancer. --- Hepatocellular carcinoma --- Hepatic metastasis --- Medicine. --- Radiology. --- Oncology. --- Proctology. --- Surgery. --- Medicine & Public Health. --- Imaging / Radiology. --- Metastasis --- Cancer --- Oncology  . --- Endocrinology. --- Radiology, Medical. --- Internal medicine --- Hormones --- Tumors --- Surgery, Primitive --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Radiological physics --- Physics --- Radiation --- Gastroenterology