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Primary Immunodeficiency Disorders: A Historic and Scientific Perspective provides a complete historical context that is crucial for students and researchers concerned with primary immunodeficiency. When researchers have a poor understanding of the way we arrived where we are in research, they can miss important points about a disease, or miss out on how to approach new diseases. This historical knowledge of research can assist greatly by showing how it was done in the past, demonstrating the successes and failures, so that it can be done better in the future. This book provides an understanding of the process going from clinical problem to lab and back to the clinic, based on historical experiences. Its chapters proceed from the discovery of the T and B cell lineages through the first BMT for immunodeficiency disorder; lab investigation and gene therapy for PID; the discovery of the gene for AT and its function; understanding cytokine defects; and many other stops along the way. Facilitates communication among physicians and other investigators concerned with immunological and inflammatory diseases Summarizes for the first time all the known facts from 60 years of primary immunodeficiency research, and teaches how an important field in medicine was established Provides stimulating discussions on developing new medical therapies Highlights the importance of studying humans to understand mechanisms of disease that affect humans.

Autoimmune diseases. --- Immunological deficiency syndromes. --- Immune deficiency syndromes --- Immunodeficiency syndromes --- Immunologic deficiency syndromes --- Immunodeficiency --- Immunologic diseases --- Syndromes --- Autoimmunologic diseases --- Autoimmunity

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Immunologic diseases. --- Immunodeficiency. --- Immunological deficiency syndromes. --- Immune System Diseases. --- Immune deficiency syndromes --- Immunodeficiency syndromes --- Immunologic deficiency syndromes --- Immunodeficiency --- Immunologic diseases --- Syndromes

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Immunology. Immunopathology --- Sociology of health --- Infectious diseases. Communicable diseases --- Klinische psychologie --- AIDS (Disease) --- specifieke problemen --- specifieke problemen. --- Immunological deficiency syndromes. --- Specifieke problemen. --- Immune deficiency syndromes --- Immunodeficiency syndromes --- Immunologic deficiency syndromes --- Immunodeficiency --- Immunologic diseases --- Syndromes --- United States --- AIDS (Disease) - United States.

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Pharmacology. Therapy --- Sexually Transmitted Diseases, Viral --- Immunologic Deficiency Syndromes --- Lentivirus Infections --- Therapeutics --- Immune System Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Sexually Transmitted Diseases --- Retroviridae Infections --- Diseases --- RNA Virus Infections --- Virus Diseases --- HIV Infections --- Complementary Therapies

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Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. These defects render patients susceptible to a variety of infectious diseases. Knowledge of normal immunity and specific warning signs and symptoms can help physicians to identify those children with underlying PIDs. This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Although the case scenarios relate to real histories, some modifications have been made for educational purposes. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy. This practical, case-oriented book will be an invaluable source of guidance on the diagnosis and treatment of patients with PIDs and will be relevant for those working in a variety of specialties and subspecialties.

Allergy. --- Immunologic deficiency syndromes -- Genetics. --- Immunologic deficiency syndromes -- Therapy. --- Immunological deficiency syndromes. --- Immunological deficiency syndromes --- Immune System Diseases --- Diseases --- Immunologic Deficiency Syndromes --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Communicable diseases --- Infection --- Virology --- Infectious diseases --- Contagion and contagious diseases --- Contagious diseases --- Microbial diseases in human beings --- Zymotic diseases --- Medicine. --- Human genetics. --- Immunology. --- Infectious diseases. --- Pediatrics. --- Biomedicine. --- Allergology. --- Infectious Diseases. --- Human Genetics. --- Microbiology --- Medical microbiology --- Epidemics --- Causes and theories of causation --- Emerging infectious diseases. --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Paediatrics --- Pediatric medicine --- Medicine --- Children --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Immunobiology --- Life sciences --- Serology --- Health and hygiene --- Diseases. --- Medical genetics. --- Medical Genetics. --- Clinical genetics --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Epidemiology --- Health --- Sick --- Genetic aspects