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This book highlights the important role of neutrophils in health as well as in the pathogenesis of various diseases. Section 1 provides a general background information regarding the mechanisms and various triggers of neutrophil extracellular traps (NETs) formation and their role in various infectious and noninfectious diseases (such as postinjury inflammation). Section 2 provides recent evidence regarding the role of neutrophils in the pathogenesis as well as a therapeutic target for selected disease conditions such as periodontal diseases, rheumatoid arthritis, and cystic fibrosis. Section 3 describes the anti-inflammatory properties of neutrophils with focus regarding their role in graft versus host disease. This book provides a wider picture with regard to the importance of this immune cell type in various diseases with focus on one of its recently discovered properties, NETs. Therapeutic targets aimed to modulate neutrophil functions might provide novel approaches in the treatment of various diseases of infectious and noninfectious origin.

MEDICAL / Hematology. --- Medicine --- Hematology --- Hemorheology --- Health Sciences

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The present book Hemorrhagic Stroke - An Update includes the updated information for professionals who are involved in the management of spontaneous intracerebral hemorrhage. This book contains detailed information about the pathophysiology of spontaneous intracerebral hemorrhage, neuroimaging approach in intracerebral hemorrhage, how to go about surgical intervention decision-making in these patients, and the rehabilitation issues in acute care and in long-term survivors. I hope that the collective contribution from the experts will make this book a valuable guide to further develop their understanding about spontaneous intracerebral hemorrhage. I am grateful to all the authors who have contributed their tremendous expertise to the present book and to my wife and daughter for their passionate support, and last but not least, I wish to acknowledge the outstanding support of Ms. Romina Skomersic, Publishing Process Manager, InTech Open Science, Croatia, who collaborated tirelessly in crafting this book.

Hemorrhoids. --- Piles (Disease) --- Rectum --- Varicose veins --- Diseases --- Medicine --- Hematology --- Hemorheology --- Health Sciences

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Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.

Thrombosis. --- Blood --- Cardiovascular system --- Protein C deficiency --- Protein S deficiency --- Coagulation --- Diseases --- Medicine --- Hematology --- Hemorheology --- Health Sciences

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It has been suspected since more than a century that disturbed ocular blood flow (OBF) may play a role in the pathogenesis of glaucoma. Reduced OBF has been measured in glaucoma patients by numberless centres with different techniques in different tissues of the eye. And reduced OBF has been proven to be of prognostic value. Nevertheless the implementation of this knowledge into clinical practice has been very slow. This practical book will help many ophthalmologists to better understand glaucoma. The reading of this book will not only improve patient care but also give the reader intellectual satisfaction.

Glaucoma -- Diagnosis. --- Glaucoma -- Physiopathology. --- Glaucoma. --- Sense Organs --- Hemorheology --- Ocular Hypertension --- Diagnostic Techniques, Cardiovascular --- Face --- Eye Diseases --- Anatomy --- Diagnostic Techniques and Procedures --- Hemodynamics --- Head --- Diseases --- Body Regions --- Cardiovascular Physiological Phenomena --- Diagnosis --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Circulatory and Respiratory Physiological Phenomena --- Phenomena and Processes --- Blood Flow Velocity --- Eye --- Glaucoma --- Medicine --- Health & Biological Sciences --- Ophthalmology & Optometry --- Diseases. --- High intraocular pressure --- Intraocular pressure, High --- Diseases and defects --- Medicine. --- Ophthalmology. --- Medicine & Public Health. --- Ophthalmology

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Cardiovascular diseases have a major impact in Western countries. Mathematical models and numerical simulations can help the understanding of physiological and pathological processes, complementing the information provided to medical doctors by medical imaging and other non-invasive means, and opening the possibility of a better diagnosis and more in-depth surgical planning.This book offers a mathematically sound and up-to-date foundation to the training of researchers, and serves as a useful reference for the development of mathematical models and numerical simulation codes. It is structured into different chapters, written by recognized experts in the field, and however it features a common thread, with consistency of notation and expressions and systematic cross-referencing. Many fundamental issues are faced, such as: the mathematical representation of vascular geometries extracted from medical images, modelling blood rheology and the complex multilayer structure of the vascular tissue, and its possible pathologies, the mechanical and chemical interaction between blood and vascular walls; the different scales coupling local and systemic dynamics. All of these topics introduce challenging mathematical and numerical problems, demanding for advanced analysis and simulation techniques. This book is addressed to graduate students and researchers in the field of bioengineering, applied mathematics and medicine, wishing to engage themselves in the fascinating task of modeling how the cardiovascular system works.

Mathematics. --- Applications of Mathematics. --- Cardiology. --- Mathematical Biology in General. --- Physiological, Cellular and Medical Topics. --- Mathematical Modeling and Industrial Mathematics. --- Partial Differential Equations. --- Differential equations, partial. --- Biology --- Physiology --- Mathématiques --- Cardiologie --- Cardiovascular system --- Mathematical models. --- Blood -- Diseases. --- Blood flow -- Mathematical models. --- Blood flow. --- Cardiovascular System --- Cardiovascular Physiological Processes --- Blood Physiological Phenomena --- Blood Physiological Processes --- Models, Biological --- Cardiovascular Physiological Phenomena --- Rheology --- Anatomy --- Investigative Techniques --- Circulatory and Respiratory Physiological Phenomena --- Models, Theoretical --- Blood Circulation --- Hemorheology --- Hemodynamics --- Models, Cardiovascular --- Blood Vessels --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Engineering & Applied Sciences --- Human Anatomy & Physiology --- Health & Biological Sciences --- Applied Mathematics --- Circulatory system --- Vascular system --- Partial differential equations. --- Applied mathematics. --- Engineering mathematics. --- Biomathematics. --- Mathematical and Computational Biology. --- Blood --- Circulation --- Animal physiology --- Animals --- Heart --- Internal medicine --- Math --- Science --- Partial differential equations --- Diseases --- Models, Mathematical --- Simulation methods --- Mathematics --- Engineering --- Engineering analysis --- Mathematical analysis