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This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The application of MRI methods for the study of colon physiology is presented to illustrate its potential applications in controlled release dosage form design. Some examples of successful in vitro-in vivo correlations show how implementing the gastrointestinal physiological variables in the new in vitro methods can improve the predictions of in vivo drug product performance. The book contains an updated review of the experimental, computational, and in vivo approaches for measuring intestinal permeability.

Gastrointestinal agents. --- Gastrointestinal agents --- Research.

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Questo volume è un ampio compendio sui lassativi. Esso copre tutti gli aspetti dell'uso clinico dei lassativi completo di informazioni fsiopatologiche correlate con la stipsi. I meccanismi d'azione delle principali classi di lassativi sono ampiamente descritti. Il testo riporta illustrazioni che aiutano a comprendere le origini dei lassativi vegetali e la farmacologia di quelli più interessanti. Medici, farmacisti, erboristi, infermieri e studenti troveranno questo volume interessante ed utile.

Laxatives. --- Cathartics --- Purgatives --- Gastrointestinal agents --- Internal medicine. --- Pharmacy. --- Internal Medicine. --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Medicine, Internal

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During the past decade there have been major efforts to plan, implement, and sustain measures for reducing the burden of human disease that accompanies helminth infections. Further impetus was provided at the Fifty-fourth World Health Assembly, when WHO Member States were urged to ensure access to essential anthelminthic drugs in health services located where the parasites - schistosomes, roundworms, hookworms, and whipworms - are endemic. The Assembly stressed that provision should be made for the regular anthelminthic treatment of school-age children living wherever schistosomes and soil-tra

Anthelmintics --- Helminthiasis --- World health --- Helminths --- Public Health. --- World Health. --- Chemotherapy --- Prevention --- immunology. --- prevention & control. --- World health. --- Helminthiasis. --- Public Health --- World Health --- Medicine --- Environment and Public Health --- Health --- Parasitic Diseases --- Antiparasitic Agents --- Invertebrates --- Health Care --- Population Characteristics --- Diseases --- Anti-Infective Agents --- Health Occupations --- Animals --- Eukaryota --- Disciplines and Occupations --- Therapeutic Uses --- Pharmacologic Actions --- Organisms --- Chemical Actions and Uses --- Chemicals and Drugs --- Communicable Diseases --- Health & Biological Sciences --- Public health. --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- One Health --- One Health Initiative --- One Medicine Initiative --- Worldwide Health --- International Health Problems --- Health Initiative, One --- Health Problem, International --- Health Problems, International --- Health, Global --- Health, One --- Health, World --- Health, Worldwide --- Initiative, One Health --- Initiative, One Medicine --- International Health Problem --- Medicine Initiative, One --- Problem, International Health --- Problems, International Health --- Aschelminthes --- Gordius --- Nematomorpha --- Parasitic Worms --- Worms, Parasitic --- Aschelminthe --- Helminth --- Nematomorphas --- Parasitic Worm --- Worm, Parasitic --- Infections, Nematomorpha --- Nematomorpha Infections --- Helminthiases --- Infection, Nematomorpha --- Nematomorpha Infection --- Antihelmintics --- Vermifuges --- Normalcy --- Normality --- Normalities --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Public --- Anthelminthics --- Helminth infections --- Helminthic infections --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Therapeutic Effects --- Effects, Therapeutic --- Uses, Therapeutic --- Eucarya --- Eukarya --- Eukaryotes --- Eukaryotas --- Eukaryote --- Animalia --- Animal --- Metazoa --- Health Professions --- Health Occupation --- Health Profession --- Occupation, Health --- Occupations, Health --- Profession, Health --- Professions, Health --- Anti-Microbial Agents --- Antiinfective Agents --- Antimicrobial Agents --- Microbicides --- Agents, Anti-Infective --- Agents, Anti-Microbial --- Agents, Antiinfective --- Agents, Antimicrobial --- Anti Infective Agents --- Anti Microbial Agents --- Population Heterogeneity --- Population Statistics --- Characteristic, Population --- Characteristics, Population --- Heterogeneity, Population --- Population Characteristic --- Statistics, Population --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Brachiopoda --- Mesozoa --- Brachiopodas --- Invertebrate --- Mesozoas --- Antiparasitic Drugs --- Antiparasitics --- Parasiticides --- Agents, Antiparasitic --- Drugs, Antiparasitic --- Parasite Infections --- Parasitic Infections --- Disease, Parasitic --- Diseases, Parasitic --- Infection, Parasite --- Infection, Parasitic --- Infections, Parasite --- Infections, Parasitic --- Parasite Infection --- Parasitic Disease --- Parasitic Infection --- International Health --- Health, International --- Healths, International --- International Healths --- World Health Organization --- Parasites --- Community Health --- Health, Community --- Preventive Medicine --- Education, Public Health Professional --- Antiparasitic agents --- Gastrointestinal agents --- Parasitic diseases --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Occupations --- Infection --- Health Workforce --- Prevention and control --- Pharmacology --- Immunology. --- Prevention & control. --- Infections --- Anthelmintic --- Antihelmintic --- Vermifuge --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Use, Therapeutic --- Anti-Infective Agent --- Anti-Microbial Agent --- Antimicrobial Agent --- Microbicide --- Agent, Anti-Infective --- Agent, Anti-Microbial --- Agent, Antimicrobial --- Anti Infective Agent --- Anti Microbial Agent --- Antiparasitic --- Global Health. --- pharmacology.