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Spermatogenesis. --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Formation
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Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms. Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.
Infertility, Male --- Spermatogenesis --- Genetic aspects --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Male infertility --- Male sterility --- Sterility, Male --- Generative organs, Male --- Infertility --- Formation --- Diseases
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Spermatogenesis --- Cellular control mechanisms --- Cellular control mechanisms. --- Genetic aspects --- Genetic aspects. --- Genetics --- Cell regulation --- Biological control systems --- Cell metabolism --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Formation --- Spermatogenesis. --- Spermatocytogenesis --- Spermiogenesis
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Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine. Researchers in the fields of biochemistry, cell biology, molecular biology, reproductive biology and proteomics will find this book of interest. "This book is far superior to any previous book on the subject. I recommend this book with great enthusiasm." Pawan K. Singal St. Boniface General Hospital Research Center .
Spermatogenesis. --- Proteomics. --- Molecular biology --- Proteins --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Formation --- Cytology. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell biology. --- Proteins. --- Protein Biochemistry. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics
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This book represents the first analysis of the evolutionary significance of sperm phenotypes and derived sperm traits and the possible selection pressures responsible for sperm-egg coevolution.An understanding of sperm evolution is fast developing and promises to shed light on many topics from basic reproductive biology to the evolutionary process itself as well as the sperm proteome, the sperm genome and the quantitative genetics of sperm. The Editors have identified 15 topics of current interest and biological significance to cover all aspects of this bizarre, fascinating and importa
Spermatozoa. --- Spermatogenesis. --- Evolution (Biology) --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Biology --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Male gametes --- Sperm --- Gametes --- Semen --- Formation
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Advances in technology now offer promising solutions to deal with the chronological aging of the cell, tissue or organ to synchronize its existence and its use. This book covers the developments in and benefits of the latest vitrification technology and its extensive applications in reproductive medicine. Protocols of gametes (oocyte and sperm), embryos, blastocysts and ovarian tissue cryopreservation have been reviewed by leaders in the field. In order to address the escalation in cross-border reproductive tourism entailing the transfer of reproductive cells and tissues rather than the patient, the challenges, caution and emerging possibilities of nitrogen vapor shipment of vitrified cells have been discussed. Current perspectives on oocyte banking present the reader with options and solutions to effectively utilize these gametes despite the physiological deterrants.The versatile applications and potential of vitrification of human embryonic stem cells, discussed in the concluding chapter, is an exciting reality offered by vitrification to help overcome numerous stumbling blocks in the management of various disorders. .
Medicine & Public Health. --- Reproductive Medicine. --- Gynecology. --- Obstetrics/Perinatology. --- Medicine. --- Obstetrics. --- Médecine --- Gynécologie --- Obstétrique --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Reproductive technology. --- Gametogenesis. --- Assisted reproduction --- Reproduction --- Formation of gametes --- Gametes --- Technological innovations --- Formation --- Reproductive medicine. --- Biotechnology --- Cell differentiation --- Obstetrics/Perinatology/Midwifery. --- Gynaecology --- Generative organs, Female --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Maternal-fetal medicine --- Diseases --- Health aspects --- Gynecology .
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This book is focused on Sertoli cell physiology and its role in the spermatogenic event. These cells, known as “nurse cells”, are essential for the normal development of germ cells by offering not only physical support and creating an immune-privileged environment, but also for providing nutritional support. The presence of Sertoli cells promotes the establishment of the appropriate microenvironment so that spermatogenesis may occur. Spermatogenesis maintenance in vivo is highly dependent on the metabolic cooperation established between Sertoli cells and developing germ cells. For many years this metabolic cooperation between testicular cells has been disregarded, but recent advances have highlighted the relevance of these processes for male fertility. Thus, the understanding of the functioning and regulation of these metabolic processes is a crucial step to identify key mechanisms associated with Sertoli cell (dys)function and to enlighten their influence on male fertility.
Medicine. --- Cell culture. --- Biomedicine. --- Biomedicine general. --- Cell Culture. --- Spermatogenesis. --- Sertoli cells --- Metabolism. --- Cells of Sertoli --- Sertoli's cells --- Sustentacular cells --- Formation of spermatozoa --- Spermatozoa --- Formation --- Cells --- Testis --- Gametogenesis --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cultures (Biology) --- Cytology --- Technique --- Health Workforce --- Biomedicine, general.
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Darwin identified the existence of separate male and female gametes as one of the central mysteries of evolutionary biology. 150 years later, the question of why male gametes exist remains an intriguing puzzle. In this, the first book solely devoted to the evolution of anisogamy, top theorists in the field explore why gamete dimorphism characterizes nearly all plants and animals. Did separate male and female gametes evolve as a result of competition, or does anisogamy instead represent selection for cooperation? If disruptive selection drove the evolution of anisogamy, with male gametes focused on search and fusion, and female gametes provisioning the new zygote, why do some algal species continue to produce gametes of a single size? Does sperm limitation, or escape from infection, better explain the need for extremely small, highly mobile sperm? Written by leaders in the field, this volume offers an authoritative and cutting-edge overview of evolutionary theory.
Gametes --- Gametogenesis. --- Natural selection. --- Plants --- Reproduction, Asexual. --- Asexual reproduction --- Gemmation (Zoology) --- Spores --- Gemmation (Botany) --- Plant reproduction --- Plant physiology --- Reproduction --- Plants, Sex in --- Plant spores --- Darwinism --- Selection, Natural --- Genetics --- Variation (Biology) --- Biological invasions --- Evolution (Biology) --- Heredity --- Formation of gametes --- Cell differentiation --- Germ cells --- Evolution. --- Reproduction. --- Formation
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Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication.
Sertoli cells. --- Germ cells. --- Spermatogenesis. --- Infertility, Male. --- Male infertility --- Male sterility --- Sterility, Male --- Generative organs, Male --- Infertility --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Gametocytes --- Germ-line cells --- Germline --- Reproductive cells --- Sex cells --- Cells --- Germplasm resources --- Cells of Sertoli --- Sertoli's cells --- Sustentacular cells --- Testis --- Diseases --- Formation --- Medicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general. --- Medicine --- Biology --- Biomedical Research. --- Research. --- Biological research --- Biomedical research
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In the past thirty years, significant advances have been made in the field of reproductive biology in unlocking the molecular and biochemical events that regulate spermatogenesis in the mammalian testis. It was possible because of the unprecedented breakthroughs in molecular biology, cell biology, immunology, and biochemistry. In this book entitled, Molecular Mechanisms in Spermatogenesis, a collection of chapters has been included written by colleagues on the latest development in the field using genomic and proteomic approaches to study spermatogenesis, as well as different mechanisms and/or molecules including environmental toxicants and transcription factors that regulate and/or affect spermatogenesis. The book begins with a chapter that provides the basic concept of cellular regulation of spermatogenesis. A few chapters are also dedicated to some of the latest findings on the Sertoli cell cytoskeleton and other molecules (e.g., proteases, adhesion proteins) that regulate spermatogenesis. These chapters contain thought-provoking discussions and concepts which shall be welcomed by investigators in the field. It is obvious that many of these concepts will be updated and some may be amended in the years to come. However, they will serve as a guide and the basis for investigation by scientists in the field.
Spermatogenesis. --- Testis --- Molecular aspects. --- Testes --- Testicle --- Endocrine glands --- Generative organs, Male --- Gonads --- Scrotum --- Formation of spermatozoa --- Spermatozoa --- Gametogenesis --- Formation --- 537.8 --- 537.8 Electromagnetism. Electromagnetic field. Electrodynamics. Maxwell theory --- Electromagnetism. Electromagnetic field. Electrodynamics. Maxwell theory --- Medicine. --- Molecular Medicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Molecular biology. --- Biomedicine, general. --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology
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