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This colligated Special Issue of Pharmaceutics on Precision Medicine: Applied Concepts of Pharmacogenomics in Patients with Various Diseases and Polypharmacy offers to the reader a series of articles that describe the concept of Precision Medicine, discuss its implementation process and limitations, demonstrate its value by illustrating some clinical cases, and open the door to new and more sophisticated techniques and applications.

fibromyalgia (FM) --- myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) --- microRNA --- miRNome --- pharmacogenomics --- pharmacoepigenomics --- SM2miR --- Pharmaco-miR --- repoDB --- ME/CFS Common Data Elements (CDEs) --- dihydropyrimidine dehydrogenase --- DPYD --- 5-fluorouracil --- fluoropyrimidine --- therapeutic drug monitoring --- orthotopic liver transplant --- busulfan --- glutathione S-transferase --- genetic polymorphism --- limited sampling strategy --- pharmacokinetics --- clinical pharmacogenetics --- pharmacogenetic testing --- adverse drug reactions --- genotype --- phenotype --- pharmacogene --- barriers to pharmacogenetics implementation --- Sub-Saharan Africa --- chronic low back pain (cLBP) --- genetics --- personalized treatment --- polymorphism --- CYP450 --- tacrolimus --- CYP3A5 --- liver transplant --- pharmacogenomic --- minority --- data collection --- drug --- biomarker --- pharmacogenetics --- pharmacogenetic test --- personalized medicine --- gene expression --- infliximab --- adalimumab --- ulcerative colitis --- Crohn disease --- inflammatory bowel disease --- n/a