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The Third Edition of Knowles Neoplastic Hematopathology has been thoroughly updated by the world's experts to cover all aspects of neoplastic hematopathology, a field that covers disorders of the bone marrow, spleen, and lymphatic system. Now in full-color, this completely revised and expanded edition integrates the basic science, modern diagnostic techniques, and clinical aspects of malignant diseases affecting these organs. It is the most comprehensive, encyclopedic textbook concerning neoplastic hematopathology available on the market today.

Lymphoproliferative disorders --- Hematopoietic system --- Hematopoietic system. --- Bone marrow --- Hemopoietic system --- Hematopoiesis --- Immunoproliferative disorders --- Lymphoproliferative syndrome --- Cell proliferation --- Immunological deficiency syndromes --- Lymphatics --- Lymphomas --- Cytopathology. --- Cancer --- Diseases. --- Diseases --- Hematopoietic System --- Bone Marrow Diseases --- Hematologic Neoplasms --- Leukemia --- Lymphoproliferative Disorders --- pathology

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Myeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of these diseases have arisen following the discovery of the JAK2 V617F mutation in the majority of patients with bcr/abl-negative MPNs.   This book comprises evidence-based reviews and expert consensus results. It offers comprehensive coverage of relevant laboratory and clinical advances and places great emphasis on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic  approaches, the value and limitations of mutation screening for diagnostic and  prognostic purposes, risk stratification in terms of both survival and other  disease complications such as leukemic transformation and thrombosis, and  modern therapeutic strategies, including conventional drugs, allogeneic stem cell  transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.

Neoplasms -- genetics -- Laboratory Manuals. --- Neoplasms. --- Hematologic Neoplasms --- Bone Marrow Diseases --- Hematologic Diseases --- Neoplasms by Site --- Hemic and Lymphatic Diseases --- Neoplasms --- Diseases --- Bone Marrow Neoplasms --- Myeloproliferative Disorders --- Medicine --- Health & Biological Sciences --- Pathology --- Myeloproliferative disorders. --- Bone marrow --- Tumors. --- Myeloproliferative syndrome --- Medicine. --- Internal medicine. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Internal Medicine. --- Oncology  . --- Tumors --- Medicine, Internal --- Haematology --- Internal medicine --- Blood

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Provides a visual presentation of myeloproliferative neoplasms and myeloid leukaemia, meeting the needs of haematologists and clinical chemists. Covers clinical presentation, haematological and pathological features, immunophenotyping and cytogenetic and genetic abnormalities. Heavily illustrated throughout with colour photographs and diagrams, this resource fills a gap in the literature and is an essential reference for all haematologists.

Bone marrow -- Diseases -- Diagnosis. --- Bone marrow -- Diseases. --- Bone Marrow -- Pathology. --- Bone Marrow Diseases -- Diagnosis. --- Myeloid leukemia -- Atlases. --- Myeloproliferative disorders -- Atlases. --- Tumors -- Atlases. --- Leukemia --- Bone Marrow Diseases --- Hematologic Diseases --- Neoplasms by Histologic Type --- Myeloproliferative Disorders --- Leukemia, Myeloid --- Neoplasms --- Hemic and Lymphatic Diseases --- Diseases --- Medicine --- Health & Biological Sciences --- Hematological Diseases --- Blood Diseases --- Blood Disease --- Disease, Blood --- Disease, Hematologic --- Disease, Hematological --- Diseases, Blood --- Diseases, Hematologic --- Diseases, Hematological --- Hematologic Disease --- Hematological Disease --- Bone Marrow Disease --- Disease, Bone Marrow --- Diseases, Bone Marrow --- Marrow Disease, Bone --- Marrow Diseases, Bone --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Leukemia, Monocytic, Chronic --- Monocytic Leukemia, Chronic --- Granulocytic Leukemia --- Leukemia, Granulocytic --- Leukemia, Myelocytic --- Leukemia, Myelogenous --- Myelocytic Leukemia --- Myelogenous Leukemia --- Myeloid Leukemia --- Chronic Monocytic Leukemia --- Chronic Monocytic Leukemias --- Granulocytic Leukemias --- Leukemia, Chronic Monocytic --- Leukemias, Chronic Monocytic --- Leukemias, Granulocytic --- Leukemias, Myelocytic --- Leukemias, Myelogenous --- Leukemias, Myeloid --- Monocytic Leukemias, Chronic --- Myelocytic Leukemias --- Myelogenous Leukemias --- Myeloid Leukemias --- Disorder, Myeloproliferative --- Disorders, Myeloproliferative --- Myeloproliferative Disorder --- Histological Type of Neoplasm --- Histological Types of Neoplasms --- Neoplasms by Histological Type --- Neoplasm Histological Type --- Neoplasm Histological Types --- Neoplasms Histological Type --- Neoplasms Histological Types --- Hematology --- Hematologic Neoplasms --- Malignant Neoplasms --- Malignant Neoplasm --- Neoplasm, Malignant --- Neoplasms, Malignant --- Medical Oncology --- Blood and Lymphatic System Disorders

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From the world renowned Fred Hutchinson Cancer Research Center, this book is written for all physicians who treat patients with acute or chronic leukemias or myelodysplasia.  It is designed to answer questions about treatment approaches that commonly arise in day-to-day practice.  In keeping with the Center’s groundbreaking  research in bone marrow transplantation, the book provides exceptional coverage of the role of allogeneic transplant in treatment.  It also addresses the important issues of supportive care and long-term complications of successful treatment.   •Edited and written by experts at the Fred Hutchinson Cancer Research Center •Clinically focused and comprehensive coverage of treatment approaches •Allogeneic transplant addressed in detail •Separate chapters on supportive care and long-term complications.

Blood -- Diseases -- Treatment. --- Leukemia -- Treatment. --- Leukemia --- Bone Marrow Diseases --- Neoplasms by Histologic Type --- Hematologic Diseases --- Neoplasms --- Diseases --- Hemic and Lymphatic Diseases --- Myelodysplastic Syndromes --- Medicine --- Health & Biological Sciences --- Pathology --- Treatment --- Treatment. --- Leucaemia --- Leucemia --- Leucocythaemia --- Leucocythemia --- Leucosis --- Leukaemia --- Leukosis --- Medicine. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Oncology  . --- Haematology --- Internal medicine --- Blood --- Tumors

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Introduction The understanding of the genetic, epigenetic, immuno- well as for practicing hematologists or oncologists. logical and biological causes of myeloproliferative dis- Each chapter follows a similar architecture and leads orders has substantially improved in the last few years. through epidemiology, genetic and molecular causes, Together with refined tools in pathology, the successful hematological and clinical findings, prognostic factors establishment of mouse models mimicking at least some and current treatment approaches of the diseases. of the myeloproliferative disorders, and murine models Effort has been made to point out the evolving field of novel drugs in this arena but simultaneously diff- allowing to carefully dissect the role of mutations and gene dosage effects of, for example JAK2, this has led to entiate between standard and experimental treatment ever increasing numbers of modified classification approaches. schemes. It is therefore important for the heamtologist Together with the co-editors and all the authors of or oncologist to keep up with this rapid change in classi- the various chapters I hope that the readers of the book fication language, the upcoming of new entities or differ- will enjoy reading and benefit from the information entiation between, or subclassification of, rare diseases provided.

Myeloid leukemia --Epidemiology. --- Myeloid leukemia --Pathophysiology. --- Myeloid leukemia --Treatment. --- Myeloproliferative disorders --Epidemiology. --- Myeloproliferative disorders --Pathophysiology. --- Myeloproliferative disorders --Treatment. --- Myeloproliferative disorders --- Myeloid leukemia --- Bone Marrow Diseases --- Leukemia --- Leukemia, Myeloid --- Myeloproliferative Disorders --- Neoplasms by Histologic Type --- Hematologic Diseases --- Neoplasms --- Hemic and Lymphatic Diseases --- Diseases --- Medicine --- Oncology --- Health & Biological Sciences --- Epidemiology --- Pathophysiology --- Treatment --- Bone marrow --- Myeloproliferative disorders. --- Myelodysplastic syndromes. --- Diseases. --- Dysmyelopoietic syndromes --- Myeloproliferative syndrome --- Dysplasia --- Medicine. --- Internal medicine. --- Blood transfusion. --- Oncology. --- Medicine & Public Health. --- Internal Medicine. --- Blood Transfusion Medicine. --- Syndromes --- Preleukemia --- Oncology  . --- Blood transfusion --- Blood transfusion therapy --- Hemotherapy --- Transfusion medicine --- Transfusion of blood --- Transfusion therapy --- Transfusion therapy, Blood --- Surgery --- Blood banks --- Blood groups --- Hospitals --- Transfusion-free surgery --- Medicine, Internal --- Tumors --- Transfusion committees