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As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spectacular reappearances, and the latest peak of 40,000 reported and over 300,000 estimated cases only dates back to 1998. Efforts of the WHO and partners as well as the development of simpler and much better-tolerated treatments, improved diagnostics, and vector control tools made it possible to reduce this number by 95%. Case identification and confirmation remain complex and require specific skills, treatment remains error-prone and reports on long-term survivors have emerged, and the relevance of the animal reservoir for T. b. gambiense HAT needs clarification. In addition, to win the “end game” against this massively stigmatized disease, the human factor will play a key role. This Special Issue addresses many of the burning topics about disease elimination in its 12 research and 7 review articles and one case study. The papers critically reflect the approaches used, investigate the mentioned challenges, and propose novel approaches and interventions from various points of view.

(+)-spectaline --- iso-6-spectaline --- Trypanosoma brucei rhodesiense --- autophagy --- apoptosis --- cross-talk --- trypanosomosis --- iron --- transferrin --- transferrin receptor --- nutritional immunity --- flagellar pocket --- Human African Trypanosomiasis (HAT) --- mydriasis --- neurological signs --- eradication --- re-emergence --- human African trypanosomiasis --- treatment --- melarsoprol --- adverse event --- encephalopathy --- human leukocyte antigen --- association study --- disease elimination --- disease eradication --- frontline workers --- DR Congo --- mobile screening --- qualitative methods --- sequelae --- serology --- oligosymptomatic HAT --- product development partnerships --- research and development --- medical innovation --- donor policy --- African trypanosomiasis --- sleeping sickness --- trypanosoma brucei --- drugs --- drug resistance --- history --- human Africa trypanosomiasis --- fexinidazole --- home-based treatment --- patient-centred care --- Uganda --- elimination --- T. b. gambiense --- g-HAT --- T. b. rhodesiense --- r-HAT --- neglected tropical diseases --- Trypanosoma brucei --- drug discovery --- high-throughput screening --- blood–brain barrier --- brain permeability --- pharmacology --- phenotypic drug screening --- Haemoparasites --- animal reservoirs --- Trypanosoma growth inhibitors --- chemotherapy --- pafuramidine --- acoziborole --- African sleeping sickness --- development of treatment --- suramin --- medical history --- political history --- clinical research --- health system strengthening --- South Sudan --- diagnosis --- symptoms --- treatment-seeking --- case detection --- embodiment --- expertise --- serendipity --- CATT positive serological suspects --- active follow-up strategy --- n/a --- blood-brain barrier

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Sterols and other isoprenoids are of great interest for their molecular structure and function in cell architecture and evolution, as well as for their importance in medicine and agriculture. Molecules’ 2019 Festschrift Special Issue in honor of the 65th birthday of Prof. W. David Nes, an internationally recognized chemical biologist and recipient of the George Schroepher medal for sterol research, focuses on recent developments in the chemistry, biosynthesis, and function of these polycyclic natural products. This volume of Molecules contains 16 leading-edge review articles and original research contributions from an international cast of scientists. This volume is grouped into three sections: (i) isoprenoid metabolome and diversity, (ii) clinical evaluation of sterol and triterpene structures and biosynthesis, and (iii) methods and synthesis of steroids and other compounds. The volume will be a valuable reference tool for those who study medicinal chemistry, protein chemistry, and biochemistry of isoprenoid lipids.

high-fat high-carbohydrate diet --- toxicity --- oxysterol --- n/a --- squalene cyclase --- sterol content --- sterolomics --- Polystichum --- Smith-Lemli-Opitz syndrome --- antifungals --- alkaloid --- cycloartenol synthase --- degeneration --- phytosterol --- Rhizopus arrhizus --- fibroblasts --- pod-blast --- fern --- cholesterol --- cytotoxic activity --- N-methylpiperidine. reductive deamination --- genetic disease --- isoprenoid --- steroid --- atherosclerosis --- granatane --- antioxidant --- wound healing --- development --- enzyme-assisted derivatization --- maturity --- terpene --- keratinocytes --- C4-demethylation complex (C4DMC) --- ?-sitosterol --- mesocarp --- sterol biosynthesis --- mechanism-based inactivators --- Mucorales --- gas chromatography-mass spectrometry (GC-MS) --- Girard reagent --- ROS --- sterol pattern --- N-methylcadaverine --- ?-tocopherol --- electrospray ionization-mass spectrometry --- human African trypanosomiasis --- HUVECs --- lipidomics --- campesterol --- triterpene --- oxyphytosterol --- leishmania --- Chagas disease --- LOX-1 --- sterol C24-methyltransferase --- antifungal effectivity --- ergosterol biosynthesis --- hormone --- glucose homeostasis --- retina --- solanaceae --- cholestanoic acid --- algal sterols --- cell migration --- withanolides --- insulin resistance --- Zingiber officinale --- posaconazole --- synthesis --- pre-diabetes --- pharmacognosy --- sterol --- 4-methylsterol --- oleanolic acid --- antiparasitic drugs --- lupeol --- oilseed --- aurelianolides --- divalent metal co-factor ligation --- bile alcohol --- phytosterols --- azoles --- infectious disease --- gingerols --- UV-radiation --- oil bodies --- ZnO --- sterol 14?-demethylase --- stigmasterol

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Networks in Tropical Medicine explores how European doctors and scientists worked together across borders to establish the new field of tropical medicine in the late nineteenth and early twentieth centuries. The book shows that this transnational collaboration in a context of European colonialism, scientific discovery, and internationalism shaped the character of the new medical specialty. Even in an era of intense competition among European states, practitioners of tropical medicine created a transnational scientific community through which they influenced each other and the health

Tropical medicine --- African trypanosomiasis --- Public health --- Community health --- Health services --- Hygiene, Public --- Hygiene, Social --- Public health services --- Public hygiene --- Social hygiene --- Health --- Human services --- Biosecurity --- Health literacy --- Medicine, Preventive --- National health services --- Sanitation --- African sleeping sickness --- Gambesian sleeping sickness --- Rhodesian sleeping sickness --- Sleeping-sickness --- Sleeping sickness, Protozoan --- Trypanosomiasis --- Diseases, Tropical --- Hygiene, Tropical --- Medicine --- Public health, Tropical --- Sanitation, Tropical --- Tropical diseases --- Medical climatology --- Colonies --- History. --- International cooperation --- Prevention --- France --- Germany --- Alemania --- Ashkenaz --- BRD --- Bu̇gd Naĭramdakh German Uls --- Bundesrepublik Deutschland --- Deutsches Reich --- Deutschland --- Doitsu --- Doitsu Renpō Kyōwakoku --- Federal Republic of Germany --- Federalʹna Respublika Nimechchyny --- FRN --- German Uls --- Germania --- Germanii︠a︡ --- Germanyah --- Gjermani --- Grossdeutsches Reich --- Jirmānīya --- KhBNGU --- Kholboony Bu̇gd Naĭramdakh German Uls --- Nimechchyna --- Repoblika Federalin'i Alemana --- República de Alemania --- República Federal de Alemania --- Republika Federal Alemmana --- Vācijā --- Veĭmarskai︠a︡ Respublika --- Weimar Republic --- Weimarer Republik --- ХБНГУ --- Германия --- جرمانيا --- ドイツ --- ドイツ連邦共和国 --- ドイツ レンポウ キョウワコク --- Germany (East) --- Germany (Territory under Allied occupation, 1945-1955) --- Germany (Territory under Allied occupation, 1945-1955 : British Zone) --- Germany (Territory under Allied occupation, 1945-1955 : French Zone) --- Germany (Territory under Allied occupation, 1945-1955 : Russian Zone) --- Germany (Territory under Allied occupation, 1945-1955 : U.S. Zone) --- Germany (West) --- Holy Roman Empire --- Bro-C'hall --- Fa-kuo --- Fa-lan-hsi --- Faguo --- Falanxi --- Falanxi Gongheguo --- Faransā --- Farānsah --- França --- Francia (Republic) --- Francija --- Francja --- Francland --- Francuska --- Franis --- Franḳraykh --- Frankreich --- Frankrig --- Frankrijk --- Frankrike --- Frankryk --- Fransa --- Fransa Respublikası --- Franse --- Franse Republiek --- Frant︠s︡ --- Frant︠s︡ Uls --- Frant︠s︡ii︠a︡ --- Frantsuzskai︠a︡ Rėspublika --- Frantsyi︠a︡ --- Franza --- French Republic --- Frencisc Cynewīse --- Frenska republika --- Furansu --- Furansu Kyōwakoku --- Gallia --- Gallia (Republic) --- Gallikē Dēmokratia --- Hyãsia --- Parancis --- Peurancih --- Phransiya --- Pransiya --- Pransya --- Prantsusmaa --- Pʻŭrangsŭ --- Ranska --- República Francesa --- Republica Franzesa --- Republika Francuska --- Republiḳah ha-Tsarfatit --- Republikang Pranses --- République française --- Tsarfat --- Tsorfat --- Γαλλική Δημοκρατία --- Γαλλία --- Франц --- Франц Улс --- Французская Рэспубліка --- Францыя --- Франция --- Френска република --- פראנקרייך --- צרפת --- רפובליקה הצרפתית --- فرانسه --- فرنسا --- フランス --- フランス共和国 --- 法国 --- 法蘭西 --- 法蘭西共和國 --- 프랑스 --- France (Provisional government, 1944-1946) --- Deguo --- 德国 --- Gėrman --- Герман Улс