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"Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body."--

Chemical carcinogenesis. --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenesis --- Xenobiotics --- Carcinogens --- Carcinogenicity. --- Toxicology. --- toxicity --- Carcinogens. --- toxicity.

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This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present kno

Chemical carcinogenesis. --- Genetic toxicology. --- Polycyclic aromatic hydrocarbons --- Benzenoid hydrocarbons --- PAHs (Chemicals) --- Polyarenes --- Polynuclear aromatic hydrocarbons --- Hydrocarbons --- Polycyclic aromatic compounds --- Genotoxicity --- Genotoxicology --- Toxicology --- Biochemical genetics --- Medical genetics --- Carcinogenesis --- Chemical mutagenesis --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenicity. --- Toxicology. --- Genetic aspects

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This book aims to present current state of understanding of the role of metals in human health and disease. As it will be difficult to cover all of the metals, about two scores of them, the authors will instead provide a detailed analysis of a select set of essential (Calcium, Magnesium, Selenium, Iron, copper and Zinc) and non-essential metals (Nickel, Chromium, Cadmium and Arsenic, Tungsten and Asbestos). Each chapter will have a dedicated section focusing on the binary role that some of these metals play, their carcinogenic and cancer therapeutics, by integrating epidemiological, experimental evidence with special emphasis and focus on molecular mechanisms involved in these processes. The biological analysis will also include emerging lines of evidence such as micro RNAS, kinase families, receptors, endoplasmic, mitochondrial players and epigenetics. As part of integrating the human, experimental and mechanistic data, as well as a detailed analysis into the modes of action for different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do.

Medicine. --- Cancer research. --- Molecular biology. --- Biomedicine. --- Cancer Research. --- Molecular Medicine. --- Chemical carcinogenesis. --- Metals --- Physiological effect. --- Therapeutic use. --- Metals as antiseptics --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Carcinogenesis --- Oncology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research

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This monograph provides a contemporary account of advances in chemical carcinogenesis. It promotes the view that it is alteration of the DNA by endogenous and exogenous carcinogens that ultimately leads to sporadic mutations which are a root cause of many human cancers. It deals with the metabolic activation of common classes of chemical carcinogens (tobacco carcinogens, heterocyclic amines, polycyclic aromatic hydrocarbons) and their detoxication. It describes the DNA-adducts that ensue and their repair mechanisms. It covers advances in structural-biology that provide a glimpse of both the DNA-repair process and the by-pass of DNA-lesions and how this informs the mutational code.  It also deals with the concepts of chemoprevention and biomarkers for biomonitoring human exposure. Many contemporary texts on the biology of cancer now focus almost exclusively on the molecular and cell biology of the disease and do not cover the initiating (DNA damaging events) of chemical carcinogenesis in depth. It is with this perceived gap-in knowledge that world experts in their particular fields have contributed to this monograph. This monograph will be an important reference re-source for students in training, postdoctoral scientists, and senior scientists knowledgeable in the field.

Chemical carcinogenesis. --- HEALTH & FITNESS / Diseases / Cancer. --- MEDICAL / Oncology. --- Chemical carcinogenesis --- Genetic Processes --- Noxae --- Drug Therapy --- Toxic Actions --- Genetic Phenomena --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemical Actions and Uses --- Phenomena and Processes --- Chemicals and Drugs --- Carcinogens --- DNA Damage --- Chemoprevention --- Medicine --- Health & Biological Sciences --- Oncology --- Chemical induction of cancer --- Chemical induction of neoplasms --- Chemical induction of tumors --- Chemical tumorigenesis --- Chemically induced cancer --- Chemically induced neoplasm --- Chemically induced neoplasms --- Chemically induced tumor --- Chemically induced tumors --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Carcinogenesis --- Oncology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect

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"Ideal for ophthalmologists, optometrists and busy clinicians, Drug-Induced Ocular Side Effects provides the clinically relevant information you need to diagnose and manage chemical and drug-related ocular problems. An easily accessible format, meticulous revisions and comprehensive coverage of all drugs' generic and trade names, primary uses, ocular and systemic side effects, and clinical significance make this best-selling resource the ideal reference for quick, on-the-spot consultation"--Publisher's description.

Eye Diseases --- Eye --- Drug-Related Side Effects and Adverse Reactions --- Toxicology --- Oeil --- Médicaments --- Toxicologie. --- chemically induced --- drug effects --- methods --- Maladies. --- Effets secondaires. --- Ocular pharmacology --- Drugs --- Ocular toxicology --- Eye Disorders --- Eye Disease --- Eye Disorder --- Ophthalmology --- Ocular toxicity --- Oculotoxicity --- Oculotoxicology --- Ophthalmopharmacology --- Pharmacology --- Ophthalmic drugs --- Side effects --- Drug effects --- Effect of drugs on --- Drug-Related Side Effects and Adverse Reactions. --- chemically induced. --- drug effects. --- methods.