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Drug Administration Routes --- Drug Delivery Systems --- Drug Evaluation --- Pharmaceutical Preparations --- Drug delivery systems --- Drug targeting --- Médicaments --- Periodicals. --- administration & dosage --- Periodicals --- Administration --- Dispositifs --- Périodiques --- Ciblage --- Drug Administration Routes. --- Drug Delivery Systems. --- Drug Evaluation. --- Drug Evaluation Studies --- Evaluation Studies, Drug --- Drug Evaluation Study --- Drug Evaluations --- Evaluation Study, Drug --- Evaluation, Drug --- Evaluations, Drug --- Studies, Drug Evaluation --- Study, Drug Evaluation --- Drugs, Investigational --- Drug Targeting --- Delivery System, Drug --- Delivery Systems, Drug --- Drug Delivery System --- Drug Targetings --- System, Drug Delivery --- Systems, Drug Delivery --- Targeting, Drug --- Targetings, Drug --- Dosage Forms --- Administration Routes, Drug --- Administration Route, Drug --- Drug Administration Route --- Route, Drug Administration --- Routes, Drug Administration --- administration & dosage. --- Health Sciences --- Medical Education, Training & Research --- Pharmacy and Pharmacology --- drug delivery systems --- drug targeting --- Drugs --- Site-specific drug delivery --- Targeting of drugs --- Target organs (Anatomy) --- Delivery systems, Drug --- Drug administration technology --- Drug delivery technology --- Pharmaceutical technology --- Targeting --- Dosage forms --- Delivery systems --- Pharmacology. Therapy --- farmacologie

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Intraperitoneal chemotherapy is increasingly being used as first-line treatment for ovarian cancer. Nevertheless, it is difficult for the oncologist to find a definitive text that documents both the fundamental methods required to optimize therapy and the up-to-date results of phase I, II, and III clinical trials. With this in mind, the editors of Intraperitoneal Therapy for Ovarian Cancer have assembled a team of highly experienced clinicians and researchers to cover every aspect of the subject. The topics addressed include treatment principles, patient, drug, and catheter selection, administration guidelines, the role of hyperthermia, supportive care requirements, novel drugs, and the most recent results of clinical trials. This book will be an invaluable source of information for both practicing clinical oncologists and oncologists in training, oncologists and basic and translational scientists in training.

Ovarian diiseases -- Therapy. --- Ovarian diseases -- Diagnosis. --- Ovaries -- Diseases. --- Ovaries --- Antineoplastic Protocols --- Therapeutics --- Ovarian Diseases --- Genital Neoplasms, Female --- Endocrine Gland Neoplasms --- Drug Administration Routes --- Drug Therapy, Combination --- Neoplasms by Site --- Gonadal Disorders --- Clinical Protocols --- Urogenital Neoplasms --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Endocrine System Diseases --- Adnexal Diseases --- Ovarian Neoplasms --- Infusions, Parenteral --- Antineoplastic Combined Chemotherapy Protocols --- Drug Therapy --- Neoplasms --- Female Urogenital Diseases --- Diseases --- Genital Diseases, Female --- Female Urogenital Diseases and Pregnancy Complications --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Surgery. --- Treatment. --- Medicine. --- Oncology. --- Medicine & Public Health. --- Oncology  . --- Tumors

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Due to a rapid development in biotechnology more and more macromolecular drugs such as therapeutic peptides, oligosaccharides and nucleic acids are entering the pharmaceutical arena representing unprecedented challenges from the drug delivery point of view. One of the likely greatest challenges is their oral administration presenting a series of attractive advantages. Oral Delivery of Macromolecular Drugs addresses the most critical issues for a successful oral delivery of macromolecular drugs by a detailed characterisation of the ‘enemy’s strength’ which is mainly based on the enzymatic barrier, the mucus gel barrier and the absorption barrier. Each of these barriers is described in detail in separate chapters by leading scientists in the field. The higher the knowledge about these barriers, the more potent oral macromolecular delivery systems can be generated. In the second part of this volume an overview on the likely most promising strategies to overcome these barriers is provided. Each of these strategies is described in detail in chapters being authored by worldwide academic and industrial experts. These strategies include the use of auxiliary agents such as polymeric and low molecular mass permeation enhancers, efflux pump inhibitors and enzyme inhibitors. Furthermore, these strategies are based on delivery systems such as liposomal formulations and micro- and nanoparticles. Oral Delivery of Macromolecular Drugs provides also an overview on special topics in oral macromolecular drug delivery such as oral immunization and gene delivery. Each of these chapters benefits from the results of various in vivo studies demonstrating the potential of discussed delivery systems. On the one hand macromolecular drugs can be produced more and more effectively making also low oral bioavailabilities in the range of 0.5 – 5% commercially interesting. On the other hand, oral macromolecular drug formulations are becoming more and more efficient. Taking these developments into consideration, the number of oral macromolecular delivery systems entering the market will increase considerably over the years. ‘Invasive-to-oral-conversions’ promise great rewards for those investing in this market. Oral Delivery of Macromolecular Drugs should encourage and motivate scientists in academia and industry to move in or intensively their activities in this challenging research field of great future. About the Editor Andreas Bernkop-Schnürch is the Dean of the Faculty of Chemistry and Pharmacy and Professor of Pharmaceutical Technology at the University of Innsbruck, Austria. His main interests focus on non-invasive drug delivery systems, multifunctional polymers such as thiomers, mucoadhesion and permeation enhancement. He is author of more than 200 original research and review articles and received the Research-Award of the City of Vienna (Vienna), EURAND-Award (Boston), Best of Biotech Award (Vienna), MBPW-Award (Munich), PHÖNIX Award (Mannheim), Houska-Award (Vienna) and Austrian-Nanoaward (Vienna). In addition, Andreas Bernkop-Schnürch is founder and owner of the following companies: ThioMatrix GmbH, Dr. K. Schnürch KG and Green River Polymers GmbH.

Drugs. --- Electronic books. -- local. --- Oral medication. --- Oral medication --- Drug delivery systems --- Molecular pharmacology --- Macromolecules --- Administration, Oral --- Macromolecular Substances --- Pharmaceutical Preparations --- Drug Administration Routes --- Chemicals and Drugs --- Drug Therapy --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Drugs by mouth --- Medication, Oral --- Mouth, Medication by --- Peroral medication --- Medicine. --- Pharmacology. --- Biochemistry. --- Cell biology. --- Biomedicine. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Cell Biology. --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacology --- Pharmacy --- Drugs --- Administration --- Toxicology. --- Cytology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Chemicals --- Medicine --- Poisoning --- Poisons --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Toxicology --- Drug effects --- Medical pharmacology --- Physiological effect

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Drugs --- Controlled release preparations --- Delayed-Action Preparations --- Dosage Forms --- Dosage forms --- Controlled release --- periodicals. --- Delayed-Action Preparations. --- Dosage Forms. --- Pharmaceutical Preparations. --- Médicaments --- Médicaments-retard --- Préparations-retard --- Controlled release preparations. --- Kontrollierte Wirkstofffreisetzung --- Zeitschrift --- Online-Ressource --- Formes pharmaceutiques --- Controlled release. --- Dosage forms. --- Netzpublikation --- Online-Publikation --- Computerdatei im Fernzugriff --- Online-Dokument --- On-line-Dokument --- On-line-Publikation --- Periodikum --- Zeitschriften --- Verzögerte Freisetzung --- Compounding, Drug --- Dosage forms of drugs --- Drug compounding --- Pharmaceutical compounding --- Pharmaceutical dosage forms --- Delayed-action drugs --- Prolonged-action drugs --- Slow-release drugs --- Sustained-release drugs --- Timed-release drugs --- Delayed-action preparations --- Prolonged-action preparations --- Slow-release preparations --- Sustained-release preparations --- Timed-release preparations --- Pharmaceutic Preparations --- Pharmaceutical Products --- Preparations, Pharmaceutical --- Preparations, Pharmaceutic --- Products, Pharmaceutical --- Dosage Form --- Form, Dosage --- Forms, Dosage --- Controlled-Release Preparations --- Depot Preparations --- Prolonged-Action Preparations --- Sustained-Release Preparations --- Timed-Release Preparations --- Controlled Release Preparations --- Controlled-Release Preparation --- Delayed Action Preparations --- Delayed-Action Preparation --- Depot Preparation --- Preparation, Controlled-Release --- Preparations, Controlled-Release --- Prolonged-Action Preparation --- Sustained-Release Preparation --- Timed Release Preparations --- Timed-Release Preparation --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- Elektronische Publikation --- Presse --- Fortlaufendes Sammelwerk --- Wirkstofffreisetzung --- Targeted drug delivery --- Drug delivery systems --- Controlled release technology --- Pharmacology --- Drug Dosage Calculations --- Drug Administration Routes --- Drug Delivery Systems --- Controlled-Release Formulations --- Extended Release Formulations --- Extended Release Preparations --- Slow Release Formulation --- Sustained Release Formulations --- Controlled Release Formulations --- Controlled-Release Formulation --- Extended Release Formulation --- Extended Release Preparation --- Sustained Release Formulation --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacy --- Pharmaceutical Preparations --- Drug --- Pharmaceutical --- Pharmaceutical Preparation --- Pharmaceutical Product --- Preparation, Pharmaceutical --- Product, Pharmaceutical --- Controlled Release Formulation --- Controlled Release Preparation --- Delayed Action Preparation --- Formulation, Controlled Release --- Formulations, Controlled Release --- Prolonged Action Preparation --- Release Formulation, Controlled --- Release Formulations, Controlled --- Sustained Release Preparation --- Timed Release Preparation --- Drugs. --- Médicaments. --- Formes pharmaceutiques. --- Verzögerte Freisetzung --- Médicaments --- Médicaments-retard --- Préparations-retard --- Médicaments.