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This volume looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts. Part One presents methodology aimed at determining the structures and dynamics of SH2 domains and their complexes with phosphopeptides. Part Two discusses techniques to understand and predict interactions of SH2 domains by measuring or calculating their affinity to phosphopeptides. Part Three focuses on inhibitors of SH2 domains that lead the way for chemical tool development and drug discovery. Part Four describes how to evolve and engineer SH2 domains with specific binding properties, and Part Five explores how to measure the regulation of protein tyrosine phosphatase activity through allosteric binding of peptides to SH2 domains and condensation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, SH2 Domains: Functional Modules and Evolving Tools in Biology is a valuable resource for researchers, working in the biophysical and biochemical field, who want to learn more about this exciting and versatile class of regulatory and signaling domains. .

Cytology. --- Biomolecules. --- Physical biochemistry. --- Macromolecules. --- Proteins. --- Cell Biology. --- Structural Biology.

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This volume covers all methods used to discover the composition, structure, and dynamics of the nuclear pore complex (NPC), as well as the soluble transport factors involved in the transport process. Chapters detail structural biology methods, biophysical, transport factors , and a wide range of model organisms that have been used over the years. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Nuclear Pore Complex: Methods and Protocols: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. .

Cytology. --- Biomolecules. --- Physical biochemistry. --- Macromolecules. --- Cell Biology. --- Structural Biology. --- Molecules --- Supramolecular chemistry --- Biophysical chemistry --- Biochemistry --- Physical organic chemistry --- Biological molecules --- Molecular biology --- Cell biology --- Cellular biology --- Biology --- Cells

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Biological Phenomena --- Biophysics --- Molecular biology --- Biologie moléculaire --- Biophysique --- Periodicals. --- Periodicals --- Périodiques --- Biological Phenomena. --- Biophysics. --- Biological physics --- Mechanobiology --- Biologic Phenomena --- Biological Phenomenon --- Biological Process --- Phenomena, Biological --- Biological Processes --- Phenomena, Biologic --- Phenomenon, Biological --- Process, Biological --- Processes, Biological --- molecular biosciences --- cells --- molecular biology --- quantitative biology --- Biology --- Medical sciences --- Physics --- Biology - General --- molecular biology --- biochemistry --- structural biology --- molecular therapeutics --- molecular modeling

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Medical genetics --- Genetics, Medical. --- Medical genetics. --- Egypt. --- biochemistry --- cell biology --- molecular genetics --- structural biology --- protein deficiencies --- hereditary pathogenesis --- Medical Genetics --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Genetic Diseases, Inborn --- Molecular Medicine --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genetic aspects --- A.R.E. --- Ägypten --- Ancient Egypt --- Arab Republic of Egypt --- ARE --- Egipat --- Egipet --- Egipt --- Egiptos --- Egitto --- Égypte --- Egypten --- Egypti --- Ejiputo --- Gouvernement royal égyptien --- Ijiptʻ --- Jumhūrīyat Miṣr al-ʻArabīyah --- Khēmi --- Maṣr --- Miṣr --- Misri --- Mitsrayim --- United Arab Republic

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Molecular biology --- Genetics --- Biology --- Cytogenetics --- Biologie --- Cytogénétique --- Biologie moléculaire --- Periodicals --- periodicals --- Périodiques --- Biology. --- Cytogenetics. --- Périodiques. --- Chemistry. --- Biochemistry, --- Physical Chemistry, --- Biotechnology, --- Immunology, --- Molecular biology, --- Cytogenetics, --- Biology, --- Engineering. --- Health Sciences. --- Life Sciences. --- Chemistry --- Engineering --- Health Sciences --- Life Sciences --- Biochemistry --- Physical Chemistry --- Biotechnology --- Immunology --- General and Others --- Molecular biology. --- Cytogenetic --- Molecular biochemistry --- Molecular biophysics --- Cytogenetic Analysis --- Chromosome Disorders --- Sex Chromosome Disorders --- Cytology --- Biophysics --- Biomolecules --- Systems biology --- Life sciences --- Biomass --- Life (Biology) --- Natural history --- moleculaire biologie --- cytogenetics. --- Biological Sciences. --- biology --- aerobiology --- agricultural sciences --- anatomy and morphology --- behavior --- biochemistry --- biogenesis --- biogeography --- bioinformatics --- biological properties and phenomena --- biomathematics --- botany --- cell biology --- cryobiology --- embryology --- endocrinology --- evolutionary biology --- genetics --- histology --- immunology --- ionomics --- life history --- microbiology --- molecular biology --- mycology --- natural history --- neontology --- nutrition --- organisms --- paleontology --- parasitology --- photobiology --- physiology --- psychology --- sociobiology --- structural biology --- synthetic biology --- taxonomy --- zoology --- biologists --- hematology --- laboratory techniques --- cell cycle --- chimerism --- chromosome aberrations --- chromosome morphology --- chromosome number --- chromosome transmission --- chromosomes --- crossing over --- crossover interference --- cytogenetic analysis --- heterokaryon --- homokaryon --- mixoploidy --- ploidy