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Periodical
International journal of mass spectrometry.
ISSN: 18732798 13873806 Year: 1998 Publisher: [Amsterdam] : Elsevier Science B.V.


Book
LC-MS in Drug Analysis : Methods and Protocols
Authors: ---
ISBN: 1617799343 1617799335 Year: 2012 Publisher: Totowa, NJ : Humana Press : Imprint: Humana,

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Abstract

Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Protocols provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance.  The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques.  The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents.  Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.


Book
Magnetic Resonance Neuroimaging : Methods and Protocols
Authors: ---
ISBN: 1617379921 1617379913 Year: 2011 Publisher: Totowa, NJ : Humana Press : Imprint: Humana,

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The advent of non-invasive imaging technology, such as magnetic resonance imaging (MRI), has allowed biologists and clinicians to make great strides in unraveling the secrets of the brain. In Magnetic Resonance Neuroimaging: Methods and Protocols, expert researchers in the field provide a comprehensive collection of experimental MRI protocols that can be used to non-invasively interrogate the healthy and diseased brain. The chapters are divided into general techniques, such as the measurement of relaxivity, magnetic resonance spectroscopy, diffusion tensor imaging, and MR reporter genes, as well as specific applications in brain imaging, for example, phenotyping transgenic animals, detecting amyloid plaques, and fMRI in psychiatry. As a volume in the highly successful Methods in Molecular Biology™ series, this work contains the type of detailed description and implementation advice that is crucial for getting optimal results. Thorough and cutting-edge, Magnetic Resonance Neuroimaging: Methods and Protocols serves neuroscientists, clinical neurologists, psychiatrists, and radiologists with an excellent compendium of methods easily applied to both animal and human studies and certain to be an excellent resource for translational research.


Book
NMR-Based Metabolomics : Methods and Protocols
Authors: ---
ISBN: 1493996908 1493996894 Year: 2019 Publisher: New York, NY : Springer New York : Imprint: Humana,

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This book provides broad coverage of nuclear magnetic resonance (NMR) spectroscopy-based methods and applications for the analysis of metabolites in a wide range of biological samples, from biofluids, cells, animal models, human, to plants and foods. The applications range from mechanistic understanding, biomarker discovery, environmental studies, and drug discovery to nutrition, while NMR methods include global, targeted, and isotope tracer-based techniques. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, NMR-Based Metabolomics: Methods and Protocols serves as a wealth of information for beginners as well as advanced practitioners and also as stepping stones for further advances in the field of metabolomics.


Book
Protein Aggregation : Methods and Protocols
Author:
ISBN: 1071625977 1071625969 Year: 2023 Publisher: New York, NY : Springer US : Imprint: Humana,

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The volume details techniques, methods, and conceptual developments to further the study of protein aggregation with emphasis on the pleiomorphic proteins implicated in etiology of neurodegeneration. Chapters guide readers through in vitro and in vivo studies of fibrillization and liquid-liquid phase separation processes, and offer a comprehensive account of the state-of-art of structural studies of protein aggregation. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Protein Aggregation: Methods and Protocols aims to be useful and practical guide to new researchers and experts looking to expand their knowledge.


Periodical
The Astrophysical journal.
Authors: --- ---
ISSN: 20418213 20418205 Year: 1988 Publisher: Chicago : [Bristol, Eng.] : University of Chicago Press for the American Astronomical Society IOP Pub.


Periodical

Book
Structural analysis of organic compounds by combined application of spectroscopic methods
Authors: --- ---
ISBN: 0444997482 1299923615 0444597549 9780444997487 Year: 1981 Publisher: Amsterdam : Elsevier,

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