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The initial identification of the Adenomatous polyposis coli (Apc) gene as the site of mutations in familial adenomatous polyposis (FA P) was described in 1992. A causal relationship between Apc mutations and intestinal tract tumours was confirmed three years later with the establishment of the Min mouse model. These mice are heterozygous for Apc and develop numerous intestinal tumours that mimic FA P. Subsequently, Apc has emerged as the most commonly mutated gene in colorectal cancer with reports varying between 50-80 per cent of sporadic tumours carrying such mutations. The search for how m

Adenomatous Polyposis Coli Protein. --- Adenomatous Polyposis Coli. --- Colon (Anatomy) -- Cancer. --- Colorectal Neoplasms -- Metabolism. --- Genes, APC. --- Tumor suppressor proteins. --- Colon (Anatomy) --- Tumor suppressor proteins --- Adenomatous Polyposis Coli --- Colorectal Neoplasms --- Genes, APC --- Metabolism --- Adenomatous Polyposis Coli Protein --- Intestinal Polyposis --- Intestinal Neoplasms --- Colonic Neoplasms --- Neoplastic Syndromes, Hereditary --- Colonic Diseases --- Metabolic Phenomena --- Cytoskeletal Proteins --- Genes, Tumor Suppressor --- Tumor Suppressor Proteins --- Rectal Diseases --- Adenomatous Polyps --- Proteins --- Neoplasm Proteins --- Intestinal Diseases --- Neoplasms --- Genes, Neoplasm --- Phenomena and Processes --- Gastrointestinal Neoplasms --- Genes, Recessive --- Adenoma --- Genetic Diseases, Inborn --- Gastrointestinal Diseases --- Digestive System Neoplasms --- Genes --- Diseases --- Neoplasms, Glandular and Epithelial --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Digestive System Diseases --- Genome Components --- Neoplasms by Site --- Neoplasms by Histologic Type --- Genome --- Genetic Structures --- Genetic Phenomena --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Cancer. --- Antioncoproteins --- Growth suppressor proteins --- Metastasis suppressor proteins --- Colon cancer --- Colorectal cancer --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antioncogenes --- Health Workforce --- Biomedicine, general.

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Early detection of colorectal cancers is a significant and relatively recent achievement. Persons who carry genetic mutations linked to hereditary colorectal cancer make up 20% of the patient population. With the advent of molecular genetics and the description of hereditary colorectal cancer syndromes, clinicians and genetic counselors are able to use genetic predisposition testing as an effective and important way to identify patients and families affected by inherited colorectal cancer syndromes. Hereditary Colorectal Cancer is a comprehensive collection that documents not only Familial Adenomatous Polyposis and the Lynch syndrome, but also less understood syndromes, including the Hamartomatous Polyposis Syndromes and MutYH Associated Polyposis. Internationally recognized clinicians and researchers further delve into the evolution and potential of syndromes, genes and molecular alterations that have yet to be defined. Instrumental experts in this field of discovery were carefully selected by the section editors to create this premier reference work for clinicians, scientists and researchers confronted with the treatment and management of hereditary colorectal cancer.

Medicine & Public Health. --- Oncology. --- Surgical Oncology. --- Gastroenterology. --- Medicine. --- Cancer --- Médecine --- Gastroentérologie --- Cancérologie --- Surgery. --- Chirurgie --- Colon (Anatomy) --- Genetic disorders. --- Rectum --- Colorectal Neoplasms --- Adenomatous Polyposis Coli. --- Colorectal Neoplasms, Hereditary Nonpolyposis. --- Genetic Counseling. --- Genetic aspects. --- genetics. --- Colon (Anatomy) -- Cancer. --- Rectum -- Cancer. --- Genetic disorders --- Neoplastic Syndromes, Hereditary --- Intestinal Neoplasms --- Colonic Neoplasms --- Rectal Diseases --- Adenomatous Polyps --- Biology --- Intestinal Polyposis --- Genetic Services --- Colonic Diseases --- DNA Repair-Deficiency Disorders --- Genetics, Medical --- Intestinal Diseases --- Metabolic Diseases --- Gastrointestinal Neoplasms --- Health Services --- Adenoma --- Neoplasms --- Genetic Diseases, Inborn --- Biological Science Disciplines --- Adenomatous Polyposis Coli --- Colorectal Neoplasms, Hereditary Nonpolyposis --- Genetic Counseling --- Genetics --- Neoplasms, Glandular and Epithelial --- Gastrointestinal Diseases --- Digestive System Neoplasms --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Diseases --- Health Care Facilities, Manpower, and Services --- Nutritional and Metabolic Diseases --- Natural Science Disciplines --- Digestive System Diseases --- Neoplasms by Histologic Type --- Health Care --- Neoplasms by Site --- Disciplines and Occupations --- History & Archaeology --- Medicine --- Health & Biological Sciences --- Oncology --- History - General --- Genetic aspects --- Cancer. --- Congenital diseases --- Disorders, Genetic --- Disorders, Inherited --- Genetic diseases --- Hereditary diseases --- Inherited diseases --- Colorectal cancer --- Rectal cancer --- Colon cancer --- Surgical oncology. --- Medical genetics --- Oncology  . --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Tumors --- Internal medicine --- Digestive organs --- Excision --- Treatment --- Gastroenterology .