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Metabolism --- Metabolic Diseases. --- Nutrition Disorders. --- Disorders --- Disorders.

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Biochemistry --- Clinical biochemistry --- Pathology, Molecular --- Medical genetics --- Molecular Biology. --- Endocrine System Diseases. --- Metabolic Diseases.

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Diabetes --- Obesity --- Metabolic syndrome --- Diabetes Mellitus. --- Metabolic Diseases. --- Obesity. --- Clinical Endocrinology

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Cachexia may well represent the flip side of the tremendous achievements of modern medicine. Many diseases rapidly leading patients to death just a few years ago, are now better controlled by new therapies, and even if we cannot cure and eradicate them, their natural history has significantly increased by months and years. Although these new therapeutic strategies represent a remarkable advantage over the standards of care, it is impossible to ignore that many more patients are now facing the nutritional consequences of prolonged immunological and metabolic challenges deriving from ongoing diseases and aggressive therapies. Aim of the volume, written by world-renowned scientists, is to provide the best available evidence on the pathogenesis, clinical features and therapeutic approach of cachexia, and to facilitate the understanding of the complex yet unequivocal clinical role of this syndrome, that truly represents a disease, or, better still, a disease within other different diseases.

Cachexia. --- Cachexy --- Asthenia --- Leanness --- Malnutrition --- Oncology  . --- Internal medicine. --- Geriatrics. --- Emerging infectious diseases. --- Metabolic diseases. --- Oncology. --- Internal Medicine. --- Geriatrics/Gerontology. --- Infectious Diseases. --- Metabolic Diseases. --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Medicine --- Gerontology --- Older people --- Medicine, Internal --- Tumors --- Health and hygiene --- Infectious diseases.

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Cardiovascular diseases continue to be the leading cause of death in the - jority of industrialized countries. The most frequent underlying pathology, namely atherosclerosis, and its clinical sequelae, namely coronary heart d- ease, cerebrovascular disease and peripheral artery disease, remain common although for a long time we have been made aware of avoidable or mo- ?able etiological factors such as smoking, fat-rich diet or lack of exercise, and although these adverse lifestyle factors have been extensively addressed by population-wide primary prevention programs. Cardiovascular morbidity and mortality also remain high despite successful anti-hypertensive and lipid lowering drug therapies which help to reduce cardiovascular morbidity and mortality by about 30% in both secondary and tertiary prevention settings. This can partly be explained by the increasing life expectancy and growing p- portionofelderly people,especiallyinEuropeandNorthAmerica. Inaddition, the World Health Organization makes the alarming prediction that probably in response to the spreading of western dietary behavior and lack of exercise resulting in an increasing prevalence of diabetes, dyslipidemia and hypert- sion, cardiovascular diseases rather than infectious diseases will become the most frequent cause of death worldwide. This volume of the Handbook of Experimental Pharmacology entitled “Atherosclerosis” is divided into four parts and intends to give an overview on the pathogenesis of atherosclerosis, established treatment and prevention regimen, and of perspectives for the development of new treatment modalities.

Antilipemic agents. --- Atherosclerosis. --- Arteriosclerosis --- Antilipid drugs --- Hypolipemic agents --- Hypolipidemic agents --- Lipid-lowering drugs --- Cardiovascular agents --- Hyperlipidemia --- Chemotherapy --- Cardiology. --- Toxicology. --- Angiography. --- Metabolic diseases. --- Pharmacology/Toxicology. --- Angiology. --- Metabolic Diseases. --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Blood-vessels --- Diagnosis, Radioscopic --- Radiography, Medical --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Heart --- Internal medicine --- Radiography --- Toxicology --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Drugs --- Pharmacy --- Physiological effect