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To maximize the probability of survival, cells need to coordinate their intracellular activities in response to changes in the extracellular environment. MAP kinase cascades play an important role in the transduction of signals inside eukaryotic cells. In particular, stress stimuli result in the rapid activation of a highly conserved group of MAP kinases, known as SAPKs (Stress-Activated Protein Kinases). These kinases coordinate the generation of adaptive responses that are essential for cell survival, which include the modulation of several aspects of cell physiology from metabolism to gene expression. In this book, leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signalling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signalling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis.

MAP Kinase Signaling System --- MAP Kinase Kinase Kinases --- Mitogen-Activated Protein Kinase Kinases --- Mitogen-Activated Protein Kinases --- Mitogen-activated protein kinases. --- MAP kinases --- physiology. --- metabolism. --- Protein. --- Stress. --- Mitogen-activated protein kinases --- Intracellular Signaling Peptides and Proteins --- Protein-Serine-Threonine Kinases --- Signal Transduction --- Protein-Tyrosine Kinases --- Proline-Directed Protein Kinases --- Metabolic Networks and Pathways --- Peptides --- Proteins --- Protein Kinases --- Biochemical Processes --- Metabolism --- Cell Physiological Processes --- Biochemical Phenomena --- Phosphotransferases (Alcohol Group Acceptor) --- Amino Acids, Peptides, and Proteins --- Chemical Processes --- Cell Physiological Phenomena --- Metabolic Phenomena --- Chemical Phenomena --- Chemicals and Drugs --- Phosphotransferases --- Phenomena and Processes --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Animal Biochemistry --- Biochemistry --- Biology - General --- Biology --- Human Anatomy & Physiology --- Chemistry --- Health & Biological Sciences --- Physical Sciences & Mathematics --- MAPKs (Enzymes) --- Life sciences. --- Molecular biology. --- Biochemistry. --- Cell biology. --- Life Sciences. --- Biochemistry, general. --- Cell Biology. --- Molecular Medicine. --- Protein kinases --- Cytology. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Composition --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology --- Medicine --- Biomedical Research. --- Research. --- Biological research --- Biomedical research