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The transmission of the nervous impulse is always from the dendritic branches and the cell body to the axon or functional process. Every neuron, then, possesses a receptor apparatus, the body and the dendritic prolongations, an apparatus of emission, the axon, and the apparatus of distribution, the terminal arborization of the nerve fibers. I designated the foregoing principle: the theory of dynamic polarization (Cajal 1923). Ever since the beautiful drawings from Golgi and Cajal, we have been familiar with the organisation of neurones into dendritic, somatic and axonal compartments. Cajal proposed that these cellular compartments were specialised, resulting in his concept of ^dynamic polarisation'. He considered dendrites to be passive elements that simply transferred information from inputs to the soma. Since the discovery that dendrites of many neural populations release neuroactive substances and in doing so, alter neuronal output, it is now apparent that this theory requires qualification. This book presents recent developments in the neurophysiology of dendritic release of several chemical classes of transmitters in a number of different areas of the mammalian central nervous system. Once released from a neuron, these substances can act as neurotransmitters and/or neuromodulators, to autoregulate the original neuron, its synaptic inputs, and adjacent cells or, by volume transmission, to affect distant cells. In some systems, dendritic transmitter release is part independent of secretion from axon terminal signifying a selective control of the dendritic compartment.
Neural transmission. --- Dendrites. --- Neurotransmitters. --- Nerve transmission --- Nervous transmission --- Neurotransmission --- Synaptic transmission --- Transmission of nerve impulses --- Neural circuitry --- Neurophysiology --- Neurotransmitters --- Chemical nerve transmitters --- Nerve transmitter substances --- Neural transmitters --- Neurohumors --- Neuroregulators --- Synaptic transmitters --- Transmitters, Chemical nerve --- Transmitters, Synaptic --- Neurochemistry --- Neural transmission --- Neurons --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system
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Molecular Mechanisms of Synaptogenesis is a compilation of recent exciting findings that summarizes the ever-expanding knowledge of how neuronal contacts develop in the normal brain and how their functions are affected in mental disorders. In the last decade, advances in molecular and cellular biology, combined with the development of sophisticated fluorescence microscopy tools to visualize synapses in live neurons, have revealed many intriguing and unexpected findings regarding the dynamics of synapse formation. Studies by a number of researchers have identified several critical protein components of synapses and shown the time course of their arrival at the synapse. Several molecules serve to hold the synaptic contacts between nerve cells and regulate their function. Imbalance in synaptic contact formation and function has been linked to psychiatric disorders such as schizophrenia, autism and mental retardation. The recent advances in basic research, summarized in Molecular Mechanisms of Synaptogenesis, may lay the necessary scientific groundwork to develop treatments targeting synaptogenesis, allowing us to improve the lives of people affected by brain disorders. This book will be an invaluable resource for neurobiologists taking their first steps in the expanding and exciting field of synaptogenesis.
Neural transmission. --- Synapses. --- Neurotransmitters. --- Cytoskeletal proteins. --- Presynaptic receptors. --- Neurotransmitter receptors --- Structural proteins --- Proteins --- Chemical nerve transmitters --- Nerve transmitter substances --- Neural transmitters --- Neurohumors --- Neuroregulators --- Synaptic transmitters --- Transmitters, Chemical nerve --- Transmitters, Synaptic --- Neurochemistry --- Neural transmission --- Nerve endings --- Nerves --- Neural circuitry --- Synaptosomes --- Nerve transmission --- Nervous transmission --- Neurotransmission --- Synaptic transmission --- Transmission of nerve impulses --- Neurophysiology --- Neurotransmitters --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system
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Synapses play a central role in the brain by mediating signal transmission between neurons. This book provides a fundamental description of the synapse by leading experts in the field. Each individual synapse carries out its numerous functions in a tiny space, thereby requiring an exquisite molecular and functional arrangement. This book describes the molecular structure and cellular function of central synapses in the brain, providing a detailed view of the brain’s fundamental unit of information storage.
Neural transmission. --- Synapses. --- Nerve endings --- Nerves --- Neural circuitry --- Neural transmission --- Synaptosomes --- Nerve transmission --- Nervous transmission --- Neurotransmission --- Synaptic transmission --- Transmission of nerve impulses --- Neurophysiology --- Neurotransmitters --- Neurosciences. --- Neurobiology. --- Neurology. --- Medicine --- Nervous system --- Neuropsychiatry --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases --- Neurology .
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Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience. The major aim of Transcriptional Regulation by Neuronal Activity: To the Nucleus and Back is to illustrate key advances in the field – specifically how signals are transmitted to the nucleus in response to neuronal activity, what genes are activated and how this is achieved, and how these changes in gene expression alter neuronal function. About the Author: Serena M. Dudek, Ph.D. is best known for her seminal work describing Long-term synaptic Depression (LTD) in the hippocampus. Dr. Dudek heads the Synaptic and Developmental Plasticity Group at the National Institute of Environmental Health Sciences, where her laboratory studies the cellular mechanisms of synaptic plasticity in the adult and developing mammalian brain. Although once a critic of the proposed necessity of transcription for maintenance of synaptic plasticity, Dr. Dudek now devotes much of her time to work on the topic.
Genetic transcription --- Neural transmission. --- Neuroplasticity. --- Regulation. --- Nervous system plasticity --- Neural adaptation --- Neural plasticity --- Neuronal adaptation --- Neuronal plasticity --- Plasticity, Nervous system --- Soft-wired nervous system --- Synaptic plasticity --- Nerve transmission --- Nervous transmission --- Neurotransmission --- Synaptic transmission --- Transmission of nerve impulses --- Medicine. --- Neurosciences. --- Neurology. --- Neurobiology. --- Biomedicine. --- Adaptation (Physiology) --- Neurophysiology --- Developmental neurobiology --- Neural circuitry --- Neurotransmitters --- Genetic regulation --- Neurosciences --- Medicine --- Nervous system --- Neuropsychiatry --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Diseases --- Neurology .
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Brain --- Cognition --- Human information processing --- Neural transmission --- Neural circuitry, --- physiology --- Brain. --- Cognition. --- Human information processing. --- Neural circuitry --- Neural transmission. --- Hersenen --- Neurologie --- Geheugen --- Cerveau --- Mémoire --- Neural circuitry. --- Neural circuitry,. --- Nerve transmission --- Nervous transmission --- Neurotransmission --- Synaptic transmission --- Transmission of nerve impulses --- Neurophysiology --- Neurotransmitters --- Circuitry, Neural --- Circuits, Neural --- Nerve net --- Nerve network --- Neural circuits --- Neurocircuitry --- Neuronal circuitry --- Electrophysiology --- Nervous system --- Neural networks (Neurobiology) --- Reflexes --- Information processing, Human --- Bionics --- Information theory in psychology --- Perception --- Psychology --- Cerebrum --- Mind --- Central nervous system --- Head --- Brain - physiology
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Until recently, many neuroscientists were skeptical of the idea that classical neurotransmitters could be co-released from neurons. It is now common knowledge, though, that the "one neuron, one neurotransmitter" postulate is the exception rather than the rule. Co-Existence and Co-Release of Classical Neurotransmitters provides readers with a comprehensive overview of research from the world’s leading neuroscience authors, all of whom have discovered and studied the co-existence or co-release of several pairs of neurotransmitters in neural networks. Their reviews include novel aspects of transmitter combinations, such as NA-ACh, monoamines-glutamate, ACh-glutamate, cross-talk between monoamines, GABA and ATP, and various combinations of aminoacid transmitters. Co-Existence and Co-Release of Classical Neurotransmitters will be particularly useful to neuroscience graduate students, academics, and researchers in synaptic physiology and synaptic plasticity. This book is the first of its kind to center on the timely issue of co-release of neurotransmitters, and serves as an important contribution to the re-consideration of this idea in other brain regions. About the Editor: Dr. Rafael Gutiérrez was among the first to study the physiological impact of the co-existence of glutamate and GABA in the hippocampus, particularly the developmental and activity-dependent expression of GABAergic markers in granule cells. Since 1997, Dr. Gutiérrez has been a professor of neurosciences at the Center for Research and Advanced Studies (CINVESTAV) in Mexico City. He received his PhD in Neurosciences from the National University of Mexico in 1993 and, under the prestigious Alexander von Humboldt Research Scholarship, worked for three years with pathophysiology expert Uwe Heinemann in Germany.
Neural transmission. --- Neurotransmitter Agents. --- Neurotransmitters. --- Neurotransmitters --- Neural transmission --- Physiological Effects of Drugs --- Molecular Mechanisms of Pharmacological Action --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Neurotransmitter Agents --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Chemical nerve transmitters --- Nerve transmitter substances --- Neural transmitters --- Neurohumors --- Neuroregulators --- Synaptic transmitters --- Transmitters, Chemical nerve --- Transmitters, Synaptic --- Nerve transmission --- Nervous transmission --- Neurotransmission --- Synaptic transmission --- Transmission of nerve impulses --- Medicine. --- Neurosciences. --- Neurology. --- Psychiatry. --- Psychopharmacology. --- Neurobiology. --- Biomedicine. --- Neurochemistry --- Neural circuitry --- Neurophysiology --- Medicine and psychology --- Mental health --- Psychology, Pathological --- Behavioral pharmacology --- Drugs --- Chemotherapy --- Pharmacology --- Psychotropic drugs --- Medicine --- Nervous system --- Neuropsychiatry --- Neurosciences --- Neural sciences --- Neurological sciences --- Medical sciences --- Psychotropic effects --- Diseases --- Neurology .
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Within the complex neuronal network of the nervous system, neuron-to-neuron communication occurs mainly through chemical synapses, where the presynaptic nerve terminal releases neurotransmitters that control the function of postsynaptic neurons by acting on postsynaptic receptors. Recent decades have brought groundbreaking new developments and a wealth of knowledge to this field. In Molecular Mechanisms of Neurotransmitter Release, leading experts provide concise, up-to-date information on all major molecular mechanisms involved, with complete background information and figures and diagrams to further elucidate key concepts or experiments. Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release is sure to provide a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for all those who have a general interest in the ever-evolving field of neuroscience.
Biomedicine. --- Neurosciences. --- Cell Biology. --- Neurobiology. --- Neurology. --- Human Physiology. --- Medicine. --- Human physiology. --- Cytology. --- Médecine --- Physiologie humaine --- Neurosciences --- Neurologie --- Cytologie --- Neurobiologie --- Neurotransmitters. --- Neural transmission. --- Synaptic Transmission --- Neurotransmitter Agents --- Physiological Effects of Drugs --- Signal Transduction --- Nervous System Physiological Processes --- Molecular Mechanisms of Pharmacological Action --- Electrophysiological Processes --- Physiological Processes --- Biochemical Processes --- Electrophysiological Phenomena --- Pharmacologic Actions --- Nervous System Physiological Phenomena --- Cell Physiological Processes --- Physiological Phenomena --- Musculoskeletal and Neural Physiological Phenomena --- Chemical Processes --- Biochemical Phenomena --- Chemical Actions and Uses --- Cell Physiological Phenomena --- Chemicals and Drugs --- Chemical Phenomena --- Phenomena and Processes --- Neuroscience --- Neurology --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Nerve transmission --- Nervous transmission --- Neurotransmission --- Synaptic transmission --- Transmission of nerve impulses --- Chemical nerve transmitters --- Nerve transmitter substances --- Neural transmitters --- Neurohumors --- Neuroregulators --- Synaptic transmitters --- Transmitters, Chemical nerve --- Transmitters, Synaptic --- Cell biology. --- Neural circuitry --- Neurophysiology --- Neurotransmitters --- Neurochemistry --- Neural transmission
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Cellular signal transduction --- Cell receptors --- Signal transduction --- Cell interaction --- Transduction du signal cellulaire --- Récepteurs cellulaires --- Cellules --- Periodicals. --- Périodiques --- Interaction --- Synaptic Transmission. --- Signal Transduction. --- Cell receptors. --- Cellular signal transduction. --- Neurophysiologie. --- Biosignal. --- Rezeptor. --- Receptors, Cell Surface --- Cell Communication --- Cell Interaction --- Cell-to-Cell Interaction --- Cell Communications --- Cell Interactions --- Cell to Cell Interaction --- Cell-to-Cell Interactions --- Communication, Cell --- Communications, Cell --- Interaction, Cell --- Interaction, Cell-to-Cell --- Interactions, Cell --- Interactions, Cell-to-Cell --- Cell Surface Hormone Receptors --- Endogenous Substances Receptors --- Cell Surface Receptors --- Hormone Receptors, Cell Surface --- Receptors, Endogenous Substances --- Binding Sites --- Hormones --- Ligands --- Receptor Cross-Talk --- Transmission, Neural --- Transmission, Synaptic --- Neural Transmission --- Neurotransmission --- Neural Conduction --- Synapses --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Receptor-CD3 Complex, Antigen, T-Cell --- Feedback, Physiological --- Gasotransmitters --- Periodicals --- Chemistry --- Health Sciences --- Life Sciences --- Biochemistry --- Neurology --- Physiology --- neurobiology --- pharmacology --- cell biology --- neuroendocrinology --- neurology --- Nervenphysiologie --- Nervensystem --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Physiologie --- Signal Transduction --- Synaptic Transmission --- Neurologie --- Hirnforschung --- Binding sites (Biochemistry) --- Cell membranes --- Proteins --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Cell Signaling --- Cell Surface Receptor --- Receptor, Cell Surface --- Surface Receptor, Cell --- Neurophysiologie --- Biosignal --- Rezeptor --- Neural transmission. --- Transmission nerveuse. --- Transduction du signal cellulaire. --- Nerve transmission --- Nervous transmission --- Synaptic transmission --- Transmission of nerve impulses --- Neural circuitry --- Neurophysiology --- Neurotransmitters
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Psychiatry --- Neural Transmission --- Neurosecretion --- Neural transmission --- Autonomic nervous system --- Parkinson's disease --- Neuroendocrinology --- Transmission nerveuse --- Système nerveux autonome --- Maladie de Parkinson --- Neuroendocrinologie --- periodicals --- Periodicals --- Diseases --- Périodiques --- Maladies --- Alzheimer Disease --- Biological Psychiatry --- Brain --- Nervous System Diseases --- Neurosciences --- Parkinson Disease --- Synaptic Transmission --- Neural transmission. --- 44.90 neurology --- physiopathology --- Synaptic Transmission. --- Transmission, Neural --- Transmission, Synaptic --- Neurotransmission --- Neural Conduction --- Synapses --- Alzheimer Disease. --- Biological Psychiatry. --- Nervous System Diseases. --- Neurosciences. --- Parkinson Disease. --- Idiopathic Parkinson's Disease --- Lewy Body Parkinson's Disease --- Parkinson Disease, Idiopathic --- Parkinson's Disease --- Parkinson's Disease, Idiopathic --- Parkinson's Disease, Lewy Body --- Idiopathic Parkinson Disease --- Lewy Body Parkinson Disease --- Paralysis Agitans --- Primary Parkinsonism --- Parkinsonism, Primary --- Lewy Bodies --- Manganese Poisoning --- Neuroscience --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neurology --- Biologic Psychiatry --- Psychiatry, Biological --- Psychiatry, Biologic --- Alzheimer Dementia (AD) --- Alzheimer Disease, Early Onset --- Alzheimer Disease, Late Onset --- Alzheimer Sclerosis --- Alzheimer Syndrome --- Alzheimer Type Senile Dementia --- Alzheimer's Disease --- Alzheimer's Disease, Focal Onset --- Alzheimer-Type Dementia (ATD) --- Dementia, Presenile --- Dementia, Primary Senile Degenerative --- Early Onset Alzheimer Disease --- Familial Alzheimer Disease (FAD) --- Focal Onset Alzheimer's Disease --- Late Onset Alzheimer Disease --- Primary Senile Degenerative Dementia --- Senile Dementia, Acute Confusional --- Acute Confusional Senile Dementia --- Dementia, Alzheimer Type --- Dementia, Senile --- Presenile Alzheimer Dementia --- Senile Dementia, Alzheimer Type --- Alzheimer Type Dementia --- Alzheimer Type Dementia (ATD) --- Dementia, Alzheimer (AD) --- Dementia, Alzheimer-Type (ATD) --- Disease, Alzheimer --- Disease, Alzheimer's --- Presenile Dementia --- Sclerosis, Alzheimer --- Senile Dementia --- Syndrome, Alzheimer --- physiopathology. --- Neurosecretion. --- Autonomic Nervous System --- Endocrinology --- Neurophysiology --- Internal Medicine --- Autonomic Nervous System. --- Internal Medicine. --- Medicine, Internal --- Vegetative Nervous System --- Visceral Nervous System --- Autonomic Nervous Systems --- Nervous System, Autonomic --- Nervous System, Vegetative --- Nervous System, Visceral --- Nervous Systems, Autonomic --- Nervous Systems, Vegetative --- Nervous Systems, Visceral --- System, Autonomic Nervous --- System, Vegetative Nervous --- System, Visceral Nervous --- Systems, Autonomic Nervous --- Systems, Vegetative Nervous --- Systems, Visceral Nervous --- Vegetative Nervous Systems --- Visceral Nervous Systems --- Endocrinology and Metabolism Specialty --- Metabolism and Endocrinology Specialty --- Endocrine System Diseases --- Neurosecretions --- Neurosecretory Systems --- Health Sciences --- Genetics --- Pharmacy and Pharmacology --- Toxicology --- Life Sciences --- NEUROPHYSIOLOGY --- Physiology --- Neurophysiology. --- Health Sciences. --- Toxicology. --- Life Sciences. --- periodicals. --- Système nerveux autonome --- Périodiques --- EJMEDEC EPUB-ALPHA-J EPUB-PER-FT MDNEUROL MDPHYSIO SPRINGER-E --- Nerve transmission --- Nervous transmission --- Synaptic transmission --- Transmission of nerve impulses --- Encephalon --- Brains --- Encephalons --- Alzheimer Dementia --- Alzheimer Dementias --- Alzheimer Disease, Familial (FAD) --- Alzheimer Diseases, Familial (FAD) --- Dementia, Alzheimer --- Dementias, Alzheimer --- Familial Alzheimer Diseases (FAD) --- Neural circuitry --- Neurotransmitters --- Neurologie. --- Neurology. --- Alzheimer's Diseases --- Alzheimer Diseases --- Alzheimers Diseases
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