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Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity. In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research.

Paraoxonase --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Aromatic esterase --- Arylesterase --- Esterases --- Composition --- Internal medicine. --- Cardiology. --- Diabetes. --- Metabolic diseases. --- Internal Medicine. --- Metabolic Diseases. --- Medical Biochemistry. --- Disorders of metabolism --- Metabolic diseases --- Metabolic disorders --- Metabolism, Disorders of --- Diseases --- Brittle diabetes --- Diabetes mellitus --- IDDM (Disease) --- Insulin-dependent diabetes --- Ketosis prone diabetes --- Type 1 diabetes --- Carbohydrate intolerance --- Endocrine glands --- Diabetic acidosis --- Glycosylated hemoglobin --- Heart --- Internal medicine --- Medicine, Internal --- Medicine --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology

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Not only do glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators facilitate the transfer of messages from one cell to another, they also facilitate communication among subcellular organelles. Hot Topics in Neural Membrane Lipidology provides readers with a cutting-edge, comprehensive review of these lipid mediators, their roles and association with neurological disorders, and the future direction of research on the topic. This monograph provides readers with critical data and is particularly accessible to neuroscience graduate students, teachers, and researchers. It can be used as a supplemental text for a range of neuroscience courses. Clinicians and pharmacologists will find this book useful for understanding molecular aspects of lipid mediators in acute neural trauma like stroke, spinal cord trauma, head injury, and neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and Huntington disease. About the Author: Akhlaq A. Farooqui is a leader in the field of brain phospholipases A2, bioactive ether lipid metabolism, and glutamate-mediated neurotoxicity. He has discovered the stimulation of plasmalogen-selective phospholipase A2 activity in brains from patients with Alzheimer disease, and published cutting edge research on the generation and identification of glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators in kainic acid neurotoxicity. Dr. Farooqui has authored three monographs: Glycerophospholipids in Brain: Phospholipase A2 in Neurological Disorders (2007); Neurochemical Aspects of Excitotoxicity (2008); and Metabolism and Functions of Bioactive Ether Lipids in Brain (2008). All monographs are published by Springer, New York.

Cell membranes. --- Electronic structure --Congresses. --- Membrane lipids. --- Neurons. --- Phospholipases. --- Phospholipids. --- Selenium --Congresses. --- Sphingolipids. --- Tellurium --Congresses. --- Membrane lipids --- Cell membranes --- Neurons --- Sphingolipids --- Phospholipids --- Phospholipases --- Membrane Lipids --- Neurotoxins --- Lipids --- Noxae --- Carboxylic Ester Hydrolases --- Phosphoric Diester Hydrolases --- Esterases --- Toxic Actions --- Chemicals and Drugs --- Hydrolases --- Chemical Actions and Uses --- Enzymes --- Enzymes and Coenzymes --- Animal Biochemistry --- Neurology --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Phosphatides --- Nerve cells --- Neurocytes --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- 538.91 <063> --- Biological models --- Modèles biologiques --- Modèles biologiques --- Medicine. --- Neurosciences. --- Neurochemistry. --- Neurology. --- Psychopharmacology. --- Biomedicine. --- 538.93 <063> --- 538.91 <063> Structures, including transitions--Congressen --- Structures, including transitions--Congressen --- 538.93 <063> Transport processes (except in quantum liquids and solids)--Congressen --- Transport processes (except in quantum liquids and solids)--Congressen --- Solid state physics --- Sphingosine --- Phosphates --- Cells --- Nervous system --- Membranes (Biology) --- Glycocalyces --- Endocrinology --- Mathematical models --- Data processing --- Endocrinologie --- Modèles mathématiques --- Behavioral pharmacology --- Drugs --- Chemotherapy --- Pharmacology --- Psychotropic drugs --- Neuropsychiatry --- Biochemistry --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Psychotropic effects --- Diseases --- Neurology .