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Herbal Products: Toxicology and Clinical Pharmacology, Second Edition builds upon the informative foundation laid by its predecessor. This fully revised and expanded second edition boasts over 200 new references that document efficacy studies and adverse effects and four new chapters devoted to dietary products. Practitioners and researchers will find that this volume is a comprehensive resource for objective clinical information about the potential uses, efficacy, and safety of herbal medicines. The authors recognize that the majority of available information on dietary supplements is typically provided by distributors and designed to sell a product rather than objectively inform consumers; therefore, the emphasis throughout is on information not readily available from any other source. Similar to the first edition, this volume is based on original studies published in peer-reviewed journals, as well as meta-analyses, systematic reviews, and other high-quality assessments by recognized experts.

Herbs --- Materia medica, Vegetable --- Toxicology. --- Botanical drugs --- Drugs from plants --- Medicinal plants --- Phytotherapy --- Plant drugs --- Vegetable drugs --- Materia medica --- Botanical drug industry --- Botany, Medical --- Plants, Useful --- Forbs --- Therapeutic use

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In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: “I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.” Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but “hits” can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.

Materia medica, Vegetable --- Ethnopharmacology --- Indigenous peoples --- Botanical drugs --- Drugs from plants --- Medicinal plants --- Phytotherapy --- Plant drugs --- Vegetable drugs --- Therapeutic use --- Pharmacy. --- Pharmacology. --- Pharmacology/Toxicology. --- Ethnoscience --- Pharmacology --- Traditional medicine --- Materia medica --- Botanical drug industry --- Botany, Medical

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medicinal --- aromatic --- plants --- aromatherapy --- Medicinal plants --- Aromatic plants --- Aromatic plants. --- Medicinal plants. --- Drug plants --- Plants, Useful --- Botanical drug industry --- Botany, Medical --- Materia medica, Vegetable --- Psychotropic plants --- Plants --- Essences and essential oils --- Flowers --- Fragrant gardens --- Odor

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New Perspectives on Aloe will cover research studies of aloe by the CAP (Creation Aloe Pharmaceuticals) team, which studied various aspects of aloe over a period of more than 10 years. The team was organized into two groups: the isolation and analysis group, which purified many components in terms of low molecular weight compounds, carbohydrates, proteins present in aloe, and the assay group, which determined the efficacy of those components. This type of target-oriented, organized research provides a model of how to conduct multidisciplinary research. The contents include a brief introduction of aloe, isolation, purification, and structural analysis of components, and various physiological effects of those components for possible use as health foods or drugs. Various functions identified were wound healing, angiogenesis, anti-allergy, skin whitening, stimulation of cell proliferation such as liver or kidney, protection against nephrotoxicity, and immune modulation. Moreover, we suggest standardization and quality control procedures for manufacturing raw aloe, and how to develop related products for successful application of aloe. This is important in Korea because last year the Korean government listed aloe as a health food for which the government establishes regulatory laws. Therefore, many scientists in Korea who are interested in studying health foods would be interested in this kind of text. Other major fields related to this kind of research will be medicine, biology, pharmaceutics, natural products and analytics.

Aloe --- Medicinal plants. --- Therapeutic use. --- Drug plants --- Plants, Useful --- Botanical drug industry --- Botany, Medical --- Materia medica, Vegetable --- Psychotropic plants --- Aloes --- Aloinella --- Guillauminia --- Lemeea --- Asphodelaceae --- Toxicology. --- Pharmacology/Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Toxicology --- Pharmacology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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Materia medica, Vegetable --- Phytotherapy --- Medicinal plants --- Materia medica, Vegetable. --- Medicinal plants. --- Drug plants --- Botanical drugs --- Drugs from plants --- Plant drugs --- Vegetable drugs --- Therapeutic use --- Plants, Useful --- Botanical drug industry --- Botany, Medical --- Psychotropic plants --- Materia medica --- Fitoteràpia --- Plantes medicinals --- Fitoteràpia. --- Plantes medicinals.