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Our goal for this book is to examine the contemporary therapy of rheumatoid arthritis (RA) from the increasingly important perspective of impact upon quality of life, costs and long-term health outcomes. For too long the focus has been on short­ term, symptomatic, and surrogate indicator outcomes. Yet RA is a life-long disor­der with the majority of impact on an individual patient many years following onset. Further, even in the short-term, researchers and rheumatologists have tended to emphasize measurements of disease activity such as joint counts, ESR and physi­cian's opinion as to the amount of disease activity present. It is only relatively recently that measures of structural damage, quality of life and impact on broad domains of health have been given increasing emphasis. Also, the significance of early treatment of RA in order to optimise long-term outcomes has a relatively short history [1]. We have been focussed on the disease processes as surrogates for long­ term outcomes. Until the short-term process measures are validated as surrogates of long-term effects we should also turn our attention to outcomes of disease and the impact of our management on those outcomes [2). In our view, this book is especially timely. We are at the dawn of a revolution in the management of RA and other complex immunological inflammatory disorders because their molecular, genetic and environmental mechanisms are being unrav­elled. In the process, we are revealing a substantial number of novel and significant targets for pharmacotherapy.

Medicine & Public Health. --- Medicine/Public Health, general. --- Medicine. --- Médecine --- Antirheumatic agents. --- Rheumatoid arthritis -- Chemotherapy. --- Rheumatoid arthritis. --- Antirheumatic agents --- Rheumatoid arthritis --- Rheumatic Diseases --- Autoimmune Diseases --- Therapeutic Uses --- Arthritis --- Pharmacologic Actions --- Musculoskeletal Diseases --- Connective Tissue Diseases --- Joint Diseases --- Immune System Diseases --- Arthritis, Rheumatoid --- Antirheumatic Agents --- Skin and Connective Tissue Diseases --- Diseases --- Chemical Actions and Uses --- Chemicals and Drugs --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Chemotherapy --- Chemotherapy. --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Anti-rheumatic agents --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism --- Analgesics --- Anti-inflammatory agents --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce

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The volume focuses on therapeutic targets that were identified after TNF blockade and that have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter discusses the biological rationale in great detail, including in vitro work and work in animal models, and where appropriate, results from clinical trials. The book is written by an international authorship of experts in this field. It is of interest to rheumatologists, immunologists, internists, investigators in immunology and rheumatology as well as the pharmaceutical industry.

Medicine. --- Rheumatology. --- Toxicology. --- Rheumatoid arthritis --- Arthritis, Rheumatoid --- Antirheumatic Agents --- Autoimmune Diseases --- Rheumatic Diseases --- Arthritis --- Therapeutic Uses --- Immune System Diseases --- Pharmacologic Actions --- Connective Tissue Diseases --- Musculoskeletal Diseases --- Joint Diseases --- Chemical Actions and Uses --- Diseases --- Skin and Connective Tissue Diseases --- Chemicals and Drugs --- Musculoskeletal System Diseases --- Medicine --- Health & Biological Sciences --- Research --- Treatment --- Rheumotolgy. --- Research. --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Immunology. --- Pharmacology. --- Cell biology. --- Medicine & Public Health. --- Pharmacology/Toxicology. --- Cell Biology. --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Immunobiology --- Life sciences --- Serology --- Internal medicine --- Connective tissues --- Joints --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect