Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Biofilms --- Research --- Microbiology & Immunology --- Microbial aggregation --- Microbial ecology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Protein Misfolding, Aggregation and Conformational Diseases, Part B: Molecular Mechanisms of Conformational Diseases, is a comprehensive volume providing a broad and detailed discussion of the relationships of protein misfolding and aggregation with the pathogenesis of numerous conformational diseases. While the Part A was dedicated to the description of the general mechanisms underlying protein misfolding, aggregation, and development of protein deposition disorders, this volume summarizes recent achievements in the understanding of the molecular mechanisms of conformational diseases. Research indicates that these mechanisms are highly diverse and range from the altered protein structure leading to the enhanced propensity for aggregation/deposition or the impaired functions and ending with changes in supra-molecular structures or posttranslational modification. Protein Misfolding, Aggregation and Conformational Diseases, Part B: Molecular Mechanisms of Conformational Diseases, is an ideal book for pharmaceutical scientists, molecular and cellular biologists, biochemists, immunologists, protein scientists, and biophysicists.

Protein folding. --- Cell aggregation. --- Proteins --- Pathophysiology. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Aggregation, Cell --- Cell patterning --- Cell interaction --- Microbial aggregation --- Folding of proteins --- Folding --- Conformation --- Immunology. --- Cytology. --- Cell Biology. --- Immunobiology --- Life sciences --- Serology --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Cell biology.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Throughout the biological world, bacteria thrive predominantly in surface attached, matrix enclosed, multicellular communities or biofilms, as opposed to isolated planktonic cells. This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. Growth within a biofilm can thwart immune function and antibiotic therapy and thereby complicate the treatment of infectious diseases, especially chronic and foreign device-associated infections. Modern studies of many important biofilms have advanced well beyond the descriptive stage, and have begun to provide molecular details of the structural, biochemical and genetic processes that drive biofilm formation and its dispersion. There is much diversity in the details of biofilm development among various species, but there are also commonalities. In most species, environmental and nutritional conditions greatly influence biofilm development. Similar kinds of adhesive molecules often promote biofilm formation in diverse species. Signaling and regulatory processes that drive biofilm development are often conserved, especially among related bacteria. Knowledge of such processes holds great promise for efforts to control biofilm growth and combat biofilm-associated infections. This volume tends to focus on the biology of biofilms that affect human disease. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth. The next chapters are devoted to common problematic biofilms, those that colonize venous and urinary catheters. The final series of chapters examines biofilm formation by four species that are important pathogens and well studied models, one of which, Yersinia pestis, cleverly adopts a biofilm state of growth within its insect vector to promote disease transmission to mammalian hosts.

Biofilms. --- Bacteria. --- Bacterial diversity. --- Diversity, Bacterial --- Microbial diversity --- Germs --- Microbes --- Prokaryotes --- Microbial aggregation --- Microbial ecology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Misfoldedaggregatedproteinoncewasconsideredasinterestingasyesterday’strash—a bothersome by-product of important and productive activities, to be disposed of and forgotten as quickly as possible. Yesterday’s trash has become today’s focus of cons- erable scienti?c interest for at least two reasons: (1) protein aggregates are at the core of a number of chronic degenerative diseases such as Alzheimer’s disease, and (2) - gregation poses signi?cant obstacles to the manufacture of safe, ef?cacious, and stable protein products. As interest in protein misfolding, aggregation, and stability has soared beyond the core group of traditional protein-folding scientists, and as substantial scienti?c progress in understanding and controlling protein misfolding has been achieved, the need to summarize the state of the art became manifest. Although there are many excellent texts and edited collections on protein structure and folding, these volumes tend to relegate protein misfolding and aggregation to a minor role. Review articles and books focused on the biological role of protein aggregates in diseases have been published recently. Misbehaving Proteins: Protein (Mis)folding, Aggregation, and Stability differs from theseotherrecenteffortsinitsemphasisonfundamentalcomputationalandexperimental studies and in its linkage of disparate consequences of protein misfolding (e.g., from clinical manifestations to manufacturing headaches) to their common causes.

Protein folding. --- Cell aggregation. --- Folding of proteins --- Proteins --- Aggregation, Cell --- Cell patterning --- Cell interaction --- Microbial aggregation --- Folding --- Conformation --- Proteomics. --- Biochemistry. --- Biochemical engineering. --- Biotechnology. --- Analytical biochemistry. --- Biochemistry, general. --- Biochemical Engineering. --- Analytical Chemistry. --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Chemical engineering --- Genetic engineering --- Bio-process engineering --- Bioprocess engineering --- Biotechnology --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Molecular biology --- Composition --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry --- Analytical chemistry. --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

"This book brings together the fundamental ideas of information theory and the statistical mechanics of phase transitions within the context of the neurosciences, culture, immunology and socio-psychological studies. Outlined is a program pertaining to a dynamic and semantic extension of current models for the global neuronal workspace as were previously introduced by Baars, Dretske and others. Topics include original applications of rate distortion and large deviations theory, biological renormalization, and retinal tuning as means towards understanding consciousness on the large scale. The overall treatment is concise, has been well thought out, and the mathematical details should be accessible to both students and researchers in the cognitive and life sciences." - James Glazebrook Ph.D, Eastern Illinois University, USA.

Consciousness --- Neural networks (Neurobiology) --- Mathematical models. --- Biological neural networks --- Nets, Neural (Neurobiology) --- Networks, Neural (Neurobiology) --- Neural nets (Neurobiology) --- Cognitive neuroscience --- Neurobiology --- Neural circuitry --- Apperception --- Mind and body --- Perception --- Philosophy --- Psychology --- Spirit --- Self --- Neurosciences. --- Consciousness. --- Psychology, clinical. --- Science --- Cell aggregation --- Cognitive Psychology. --- Neuropsychology. --- Philosophy of Science. --- Manifolds and Cell Complexes (incl. Diff.Topology). --- Philosophy. --- Mathematics. --- Clinical psychology. --- Aggregation, Cell --- Cell patterning --- Cell interaction --- Microbial aggregation --- Normal science --- Philosophy of science --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Psychiatry --- Psychology, Applied --- Psychological tests --- Cognitive psychology. --- Philosophy and science. --- Manifolds (Mathematics). --- Complex manifolds. --- Psychology, Cognitive --- Cognitive science --- Analytic spaces --- Manifolds (Mathematics) --- Geometry, Differential --- Topology --- Science and philosophy --- Neurophysiology --- Psychophysiology