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The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.

Proteolytic enzymes. --- Proteinase. --- Brain --- Brain chemistry. --- Pathophysiology. --- Peptide hydrolases --- Proteases --- Hydrolases --- Cerebrum --- Mind --- Central nervous system --- Head --- Proteolytic enzymes --- Neurochemistry --- Analysis and chemistry --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition

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The targeted addition of ubiquitin to proteins is now known to regulate many cellular events, with the enzymes involved in protein ubiquitination linked to a variety of clinical problems, such as cancer, heart disease, and immune dysfunction. In Ubiquitin-Proteasome Protocols, hands-on leaders in the field, many of whom originally developed the methods they describe, detail cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome- dependent functions. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.

Electronic books. -- local. --- Proteolytic enzymes -- Laboratory manuals. --- Ubiquitin -- Laboratory manuals. --- Multienzyme Complexes --- Ubiquitin --- Cysteine Endopeptidases --- Multiprotein Complexes --- Enzymes --- Cysteine Proteases --- Ubiquitins --- Endopeptidases --- Peptide Hydrolases --- Macromolecular Substances --- Proteins --- Enzymes and Coenzymes --- Hydrolases --- Chemicals and Drugs --- Amino Acids, Peptides, and Proteins --- Proteolytic enzymes --- Cysteine Endopeptidases. --- Multienzyme Complexes. --- Ubiquitine --- Enzymes protéolytiques --- metabolism. --- Laboratory manuals --- Manuels de laboratoire --- EPUB-LIV-FT SPRINGER-B LIVBIOLO --- Peptide hydrolases --- Proteases --- High mobility protein 20 --- HMP-20 --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Laboratory manuals.

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Proteases that act in the extracellular environment have been historically associated with tumorigenesis and metastasis by virtue of their ability to carry out "path-clearing" for cancer cells. In the past few years it has become clear that they also shape the pericellular signaling environment, with profound consequences for cell fate and phenotype in both normal development and disease states. The repertoire of proteases that cells and tissues coordinately regulate in order to modulate their local environment is the DEGRADOME – which in humans is represented by at least 569 proteases in five catalytic classes. "The Cancer Degradome: Proteases in Cancer Biology" , edited by Dylan Edwards, Francesco Blasi, Gunilla-Høyer-Hansen and Bonnie Sloane, covers recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how protease activity can be imaged both in vitro and in vivo; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; the links that have emerged between proteolysis and cell signaling; how the Degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to target proteolysis for therapy.

Cancer --- Proteolytic enzymes. --- Molecular aspects. --- Peptide hydrolases --- Proteases --- Hydrolases --- Oncology. --- Human genetics. --- Microbiology. --- Immunology. --- Medical virology. --- Medicine. --- Cancer Research. --- Human Genetics. --- Medical Microbiology. --- Virology. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Medical microbiology --- Virology --- Virus diseases --- Immunobiology --- Serology --- Microbial biology --- Biology --- Microorganisms --- Genetics --- Heredity, Human --- Physical anthropology --- Tumors --- Health Workforce --- Cancer research. --- Medical microbiology. --- Molecular biology. --- Microbiology --- Cancer research --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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The demand for cosmetic procedures by male patients has increased in recent years. With this trend has come the realization that male aesthetic needs are different from female aesthetic needs. This book is the first hands-on guide dedicated exclusively to the aesthetic treatment of the male patient, and provides cosmetic surgeons with important information on how to obtain a natural male look for such patients. It explains facial aesthetics and the aging process in men, as well as the current aesthetic medicine techniques available. It also offers valuable strategies for avoiding and treating undesired results. Written by internationally known experts in the field, this unique guide enables cosmetic surgeons to achieve the best possible treatment outcomes, as well as increased satisfaction in male patients.

Men -- Patients. --- Skin -- Aging -- Treatment. --- Surgery, Plastic. --- Epidemiologic Factors --- Skin and Connective Tissue Diseases --- Bacterial Proteins --- Therapeutics --- Metalloendopeptidases --- Head --- Health --- Bacterial Toxins --- Public Health --- Body Regions --- Proteins --- Diseases --- Metalloproteases --- Toxins, Biological --- Population Characteristics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Quality of Health Care --- Endopeptidases --- Peptide Hydrolases --- Anatomy --- Health Care Quality, Access, and Evaluation --- Environment and Public Health --- Health Care --- Amino Acids, Peptides, and Proteins --- Biological Factors --- Chemicals and Drugs --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Botulinum Toxins --- Men's Health --- Sex Factors --- Skin Diseases --- Cosmetic Techniques --- Face --- Surgery & Anesthesiology --- Medicine --- Health & Biological Sciences --- Dermatology --- Plastic Surgery --- Dermatology. --- Aesthetic surgery --- Cosmetic surgery --- Plastic surgery --- Reconstructive surgery --- Surgery, Aesthetic --- Surgery, Cosmetic --- Surgery, Reconstructive --- Medicine. --- Ophthalmology. --- Otorhinolaryngology. --- Plastic surgery. --- Medicine & Public Health. --- Plastic Surgery. --- Skin --- Transplantation of organs, tissues, etc. --- Plastic surgeons --- Surgery. --- Ear, nose, and throat diseases --- ENT diseases --- Otorhinolaryngology --- Surgery, Primitive --- Eye

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It has become increasingly evident in recent years that, apart from the key role that thrombin plays in the blood coagulation cascade, thrombin also elicits cellular actions via the activation of proteinase-activated receptors, which are present in many cell types. These effects of thrombin are seen in a variety of physiological as well as pathological phenomena, including vascular development and physiology, tumor progression and metastasis, neuronal functions, inflammation, angiogenesis. Thrombin: Physiology and Disease, edited by Michael E. Maragoudakis and Nikos E. Tsopanoglou, emphasizes the new developments in this important field of research and provides the basis for translating these findings into therapeutic targets.".

Optical communications. --- Semiconductors. --- Thrombin --- Blood --- Thrombolytic therapy --- Receptors, G-Protein-Coupled --- Platelet Membrane Glycoproteins --- Receptors, Peptide --- Serine Endopeptidases --- Receptors, Proteinase-Activated --- Blood Coagulation Factors --- Biological Science Disciplines --- Receptors, Cell Surface --- Serine Proteases --- Membrane Glycoproteins --- Blood Proteins --- Endopeptidases --- Biological Factors --- Natural Science Disciplines --- Receptors, Thrombin --- Physiology --- Peptide Hydrolases --- Membrane Proteins --- Chemicals and Drugs --- Disciplines and Occupations --- Proteins --- Glycoproteins --- Hydrolases --- Amino Acids, Peptides, and Proteins --- Enzymes --- Enzymes and Coenzymes --- Human Anatomy & Physiology --- Electrical & Computer Engineering --- Medicine --- Health & Biological Sciences --- Engineering & Applied Sciences --- Oncology --- Telecommunications --- Physiological effect --- Coagulation --- Thrombin. --- Thrombolytic therapy. --- Physiological effect. --- Coagulation. --- Fibrinolytic therapy --- Thrombolysis --- Thrombosis --- Blood coagulation --- Clotting of blood --- Coagulation of blood --- Fibrinogenase --- Thrombase --- Thrombosin --- Chemotherapy --- Clotting --- Large scale systems --- Systèmes de grandes dimensions --- Systèmes de grandes dimensions --- Halvledarkomponenter --- Halvledarkomponenter. --- Medicine. --- Cancer research. --- Human physiology. --- Pharmacology. --- Epidemiology. --- Biochemistry. --- Biomedicine. --- Human Physiology. --- Cancer Research. --- Pharmacology/Toxicology. --- Biochemistry, general. --- Fibrinolysis --- Hemostasis --- Anticoagulants (Medicine) --- Coagulase --- Blood coagulation factors --- Hemostatics --- Serine proteinases --- Economics --- Computer engineering --- Mathematical models --- System theory --- Economie politique --- Congresses --- Modèles mathématiques --- Congrès --- Oncology. --- Toxicology. --- Diseases --- Public health --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Tumors --- Human biology --- Human body --- Composition --- Toxicology --- Drug effects --- Medical pharmacology --- Drugs --- Pharmacy --- Cancer research --- Economics - Mathematical models - Congresses --- Large scale systems - Congresses