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This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy) have made since the seminal light microscopical studies of Alois Alzheimer, the book presents chapters on specialist topics:- transgenic mouse models of AD; the enzymology of amyloid-ß production and degradation; oxidant stress and antioxidant protection; the involvement of metal ions and the influence of chelators; the importance of amyloid-ß oligomers and fibrils, the role of cholesterol in their formation and characteristic binding of the dye Congo red; of the many AD plaque-associated proteins, ApoE4 , clusterin and acetylcholinesterase receive individual attention; the effect of amyloid-ß on neuronal membrane calcium channels and membrane fluidity are covered, as are drug interactions, the ß-sheet breaking peptides and the statins that may prevent oligomer/fibril formation in AD; the possible significance of amyloid-ß phosphorylation receives detailed attention. Overall, the book contains a broad range of current information on cellular, biochemical and structural aspects of amyloid-ß, of direct relevance to Alzheimer’s disease. .
Alzheimer's disease. --- Amyloid beta-protein. --- Alzheimer beta-protein --- Amyloid fibril protein (Alzheimer's) --- Amyloid protein A4 --- Beta-amyloid protein --- Amyloid --- Alzheimer disease --- Alzheimer's dementia --- Basal ganglia --- Presenile dementia --- Senile dementia --- Diseases
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A volume within the Subcellular Biochemistry series is an appropriate setting for the first multi-author book devoted to the new family of antioxidant and cell signalling proteins, the peroxiredoxins. Within the antioxidant and cell signalling fields, even the existence of the peroxiredoxins has yet to be appreciated by many; with this book we aim to rectify this situation. We have tried to select diverse chapter topics to cover relevant aspects of the subject and to persuade knowledgeable authors to contribute a manuscript. As almost inevitable, a few authors let us down by failing to respond, others could not submit a manuscript in time for personal reasons. These unfortunately were two of the pioneers, Earl Stadtman and Sue Goo Rhee, but we appreciate that they communicated a lot of details that helped us to reconstruct the early phase of peroxiredoxin enzymology. We have thus compiled a book that competently covers the peroxiredoxin field from its beginnings through to currently relevant topics. In the introductory Chapter 1 we provide a short historical survey of the subject, based upon the early structural and enzymic studies on peroxiredoxins, and then lead into some of our current personal interests, such as the likely continuing contribution of transmission electron microscopy (TEM) for the study of high molecular mass peroxiredoxin complexes and the association of peroxiredoxins with other proteins, and the targeting of drugs against microbial peroxiredoxins, as future therapeutic approaches.
Proteins. --- Antioxidants. --- Oxidation-reduction reaction. --- Electron transfer reaction --- Oxido-reduction --- Redox reaction --- Chemical reactions --- Chemical inhibitors --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Medical parasitology. --- Biochemistry. --- Cytology. --- Microbiology. --- Bacteriology. --- Parasitology. --- Biochemistry, general. --- Cell Biology. --- Microbiology --- Microbial biology --- Biology --- Microorganisms --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Human beings --- Human parasitology --- Parasitology --- Parasitic diseases --- Composition --- Parasites --- Cell biology.
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This volume looks at--and discusses the techniques of--a range of areas in biology in which macrophage migration inhibitory factor (MIF) is studied. Topics covered in this book include methods to quantify MIF in cell supernatants and human samples, using ELISA and western blot; detection and analysis of intracellular MIF using flow cytometry; genotyping of human MIF polymorphisms, detection of MIF expression in a marine invertebrate using rapid amplification of cDNA RACE; studying the MIF receptor CD74 in tissues using immunohistochemistry; and studying MIF in models of disease such as asthma, Plasmodium infection, and gout. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Macrophage Migration Inhibitory Factor: Methods and Protocols is a valuable resource that will help researchers gain a new understanding of MIF biology in health and disease. .
Sistema immunitari --- Sistema immunològic --- Anatomia --- Immunologia --- Cèl·lules immunocompetents --- Medul·la òssia --- Sistema limfàtic --- Immunology. --- Cytology. --- Medicine—Research. --- Biology—Research. --- Cell Biology. --- Biomedical Research. --- Cell biology --- Cellular biology --- Biology --- Cells --- Immunobiology --- Life sciences --- Serology --- Citologia --- Biologia cel·lular --- Biologia --- Citogenètica --- Citoquímica --- Migració cel·lular --- Cèl·lules --- Cèl·lules animals --- Ultraestructura (Biologia)
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Personal protective equipment. --- Block copolymers. --- Laminated materials.
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Buildings --- Earthquake engineering --- Earthquake resistant design --- Earthquake effects --- Standards --- United States.
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