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Recent major advances in our understanding of basic immunology have led to the development of powerful new adjuvants-substances that can stimulate the innate immune system and significantly improve the effectiveness of antigen-based vaccines. In Vaccine Adjuvants: Immunological and Clinical Principles, highly respected clinical immunologists and vaccine researchers detail the major research areas in this new era of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses. Among the highlights are an explanation of innate immune signaling-including Toll-like receptors-in vaccination, and a preview of emerging technologies in adjuvant research, such as microparticles and novel lipid and carbohydrate adjuvants. Authoritative and eminently practical, Vaccine Adjuvants: Immunological and Clinical Principles moves from the basic principles of the innate immune system, through the characteristics of specific adjuvants, to detailed methods for developing the safer and more effective adjuvants that will trigger these powerful immune responses, and finally to the combinations of immune responses needed for successful vaccination.

Immunological adjuvants. --- Vaccines. --- Biologicals --- Adjuvants (Immunology) --- Adjuvants, Immunologic --- Adjuvants, Immunological --- Immune adjuvants --- Immunoactivators --- Immunoadjuvants --- Immunologic adjuvants --- Immunomodulators --- Immunopotentiators --- Immunostimulants --- Biological response modifiers --- Adjuvants, Immunologic. --- Vaccines --- immunology.

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Groundwater --- Water-supply

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This book provides students with a clear and concise guide to studying undergraduate courses in qualitative consumer research and ethnography. The authors present the major qualitative research approaches used in consumer and marketing research as well as practical procedures and theoretical aspects of research design, report presentation etc. In addition to that a weekly study guide, including comprehensive reading lists, completes the book.

Social psychology. --- Consumers --- Consumer research --- Mass psychology --- Psychology, Social --- Human ecology --- Psychology --- Social groups --- Sociology --- Psychology. --- Research. --- Consumer behavior --- Customers (Consumers) --- Shoppers --- Persons --- Behavior, Consumer --- Buyer behavior --- Decision making, Consumer --- Human behavior --- Consumer profiling --- Market surveys --- Research&delete& --- Methodology --- Psychology&delete& --- E-books --- consumer research --- ethnography --- qualitative research --- Research

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The 14th volume in the series will focus on cutting edge research at the interface of hypoxia and exercise. The work will cover the range from molecular mechanisms of muscle fatigue and muscle wasting to whole body exercise on the world’s highest mountains. State of the art papers on training at high altitude for low altitude athletic performance will also be featured.

Anoxemia --- Exercise --- Physiological aspects --- Medicine. --- Human physiology. --- Neurosciences. --- Anesthesiology. --- Cardiology. --- Biochemistry. --- Biomedicine. --- Human Physiology. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Heart --- Internal medicine --- Anaesthesiology --- Surgery --- Neural sciences --- Neurological sciences --- Neuroscience --- Nervous system --- Human biology --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Composition --- Diseases