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The combinatorial index
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ISBN: 9780121413408 0121413403 9780080542409 0080542409 1281025860 9781281025869 9786611025861 6611025863 Year: 1998 Publisher: San Diego Academic Press

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Abstract

With the explosion of combinatorial solid-phase methods, access to information has become one of the main barriers facing a synthetic chemist who is contemplating a combinatorial approach to a medicinal chemistry problem. The Combinatorial Index is an answer to that problem. This compendium of methods from the primary literature provides quick and convenient access to reliable synthetic transformations as well as information on linkers and analytical methods. Each synthetic procedure is preceded by a section entitled"Points of Interest, "which highlights the strengths and weaknesses of the various studies. The index also covers the use of solution-based synthesis for the generation of molecular diversity. Key Features * Organized for rapid retrieval of published information on classes of synthetic transformations, linkers, and analytical methods * Serves as a laboratory manual for bench chemists * Includes a chapter on linkers to assist in choice of linking strategy * Discusses strengths and limitations of the various methods * Contains a structural index showing functional group transformations in solid-phase synthesis.


Book
Multidisciplinary microfluidic and nanofluidic lab on-a-chip
Authors: --- ---
ISBN: 0444594612 0444594329 9780444594617 9780444594327 Year: 2021 Publisher: [Place of publication not identified] Elsevier

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Trends in drug research III
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ISBN: 9780444507600 0444507604 9780080543239 0080543235 1281054976 9781281054975 9786611054977 6611054979 Year: 2002 Publisher: Amsterdam New York Elsevier

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The tradition of setting new trends in medicinal chemistry continued at the 13th Symposium where topics included chemical and biological diversity, new paradigms in drug action, and new insights in receptor mechanisms. Other topics of great interest discussed, and included in these proceedings, are the discoveries in green chemistry, the interface between organic synthesis and biosynthesis, the growing problem of resistant micro-organisms and the possibilities to identify new, and better, antibiotics.


Periodical
QSAR and combinatorial science (formerly Quantitative structure-activity relationships)

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Keywords

Chemistry --- QSAR (Biochemistry) --- Structure-activity relationships (Biochemistry) --- Drugs --- Quantitative Structure-Activity Relationship. --- Combinatorial Chemistry Techniques. --- Biology. --- Pharmacology. --- Relations structure-activité quantitatives (Biochimie) --- Relations structure-activité (Biochimie) --- Médicaments --- Structure-activity relationships --- Relations structure-activité --- Structure-activity relationships. --- Health Sciences --- Life Sciences --- Biochemistry --- Pharmacy and Pharmacology --- Biochemorphology --- Biomolecules --- Chemical structure-biological activity relationships --- Relationships, Structure-activity (Biochemistry) --- Quantitative structure-activity relationships (Biochemistry) --- Structure-activity relationship (Pharmacology) --- Pharmacologies --- Pharmaceutical Preparations --- Chemistry Technic, Combinatorial --- Chemistry Technics, Combinatorial --- Chemistry Technique, Combinatorial --- Combinatorial Chemistry Technic --- Combinatorial Chemistry Technics --- Combinatorial Chemistry Technique --- Technic, Combinatorial Chemistry --- Technics, Combinatorial Chemistry --- Technique, Combinatorial Chemistry --- Chemistry Techniques, Combinatorial --- Techniques, Combinatorial Chemistry --- 3D-QSAR --- QSAR --- QSPR Modeling --- Quantitative Structure Property Relationship --- Structure Activity Relationship, Quantitative --- 3D QSAR --- 3D-QSARs --- Modeling, QSPR --- Quantitative Structure Activity Relationship --- Quantitative Structure-Activity Relationships --- Relationship, Quantitative Structure-Activity --- Relationships, Quantitative Structure-Activity --- Structure-Activity Relationship, Quantitative --- Structure-Activity Relationships, Quantitative --- Medicaments --- Medications --- Medicine (Drugs) --- Medicines (Drugs) --- Pharmaceuticals --- Prescription drugs --- pharmacology --- Physical biochemistry --- Pharmaceutical chemistry --- Pharmacology --- Gene Library --- Peptide Library --- Oligonucleotide Array Sequence Analysis --- High-Throughput Screening Assays --- Click Chemistry --- Bioactive compounds --- Medical supplies --- Pharmacopoeias --- Chemotherapy --- Materia medica --- Pharmacy --- Pharmacy, Therapeutics, & Pharmacology

Solid-supported combinatorial and parallel synthesis of small-molecular-weight compound libraries
Authors: ---
ISBN: 9780080432588 0080432581 128105657X 9781281056573 9780080432571 9786611056575 6611056572 0080517366 9780080517360 0080432573 Year: 1998 Publisher: [New York] Pergamon

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Abstract

The words ""Combinatorial Chemistry"" have different meanings to different people, ranging from split and mix strategies to parallel synthesis using robots, and embracing the whole range of preparative chemistry from organic molecules, to catalyst ligands, and even inorganic solids. All of these activities have in common an attempt to expand the diversity of structure available to the chemist as well as the access to this diversity, permitting the discovery of new and valuable biological acid material properties.


Periodical
Combinatorial Chemistry - an Online Journal
ISSN: 14643383

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Abstract

A WWW only publication which contains articles on combinatorial chemistry accepted for publication in: Tetrahedron, Tetrahedron Letters, Tetrahedron:Asymmetry, Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, CarbohydrateResearch, and other relevant Elsevier Science journals. It also features specially commissioned topical reports, as well as abstracts of articles from other publications. Articles are designated with page number and are published continuously in annual volumes.

High throughput analysis for early drug discovery
Author:
ISBN: 9780124311657 0124311652 9780080472928 0080472923 9786610966875 1280966874 Year: 2004 Publisher: Amsterdam ; Boston : Elsevier,

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Abstract

This book offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages.

Trends in drug research II
Author:
ISBN: 0444826335 9780444826336 9786611144999 1281144991 0080543243 9780080543246 Year: 1998 Volume: 29 Publisher: Amsterdam New York Elsevier

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This volume of Pharmacochemistry Library comprises the text of invited lectures presented at the 11th Noordwijkerhout-Camerino Symposium Trends in Drug Research, held in Noordwijkerhout, The Netherlands, from 11-15 May 1997. In the programme attention has been given to the generation of new biological target systems and the generation of new lead molecules, with presentations on e.g. combinatorial chemistry, compound libraries, database search, high throughput screening and molecular biology. Other topics discussed were the perspectives for new medicines for the gastro-intes

Keywords

Pharmacology, Experimental --- Pharmaceutical chemistry --- Combinatorial chemistry --- Drug development --- Congresses --- Drug Design --- Chemistry, Pharmaceutical --- Pharmacology --- Pharmacologies --- Pharmaceutical Preparations --- Chemistry, Pharmaceutic --- Pharmaceutic Chemistry --- Pharmaceutical Chemistry --- Medicinal Chemistry --- Chemistry, Medicinal --- Drug Modeling --- Design, Drug --- Designs, Drug --- Drug Designs --- Drug Modelings --- Modeling, Drug --- Modelings, Drug --- pharmacology --- Conferences - Meetings --- Experimental pharmacology --- Therapeutics, Experimental --- Development of drugs --- Drugs --- New drug development --- Pharmacy --- Combinatorial organic synthesis --- Combinatorial synthesis (Organic chemistry) --- High-throughput organic synthesis --- High-throughput synthesis (Organic chemistry) --- Multiple parallel synthesis (Organic chemistry) --- Organic compounds --- Biochips --- Development --- Synthesis --- Pharmacology. --- Computer-Aided Drug Design --- Computerized Drug Design --- Pharmaceutical Design --- Computer Aided Drug Design --- Computer-Aided Drug Designs --- Computerized Drug Designs --- Design, Computer-Aided Drug --- Design, Computerized Drug --- Design, Pharmaceutical --- Designs, Computer-Aided Drug --- Designs, Computerized Drug --- Designs, Pharmaceutical --- Drug Design, Computer-Aided --- Drug Design, Computerized --- Drug Designs, Computer-Aided --- Drug Designs, Computerized --- Pharmaceutical Designs --- Pharmacology, Experimental - Congresses --- Pharmaceutical chemistry - Congresses --- Combinatorial chemistry - Congresses --- Drug development - Congresses


Book
Annotating new genes
Authors: ---
ISSN: 20500289 ISBN: 1908818123 1907568689 9781908818126 9781908818126 9781907568688 Year: 2012 Volume: no. 15 Publisher: Oxford Woodhead Publishing Limited

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Abstract

In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases and software available, before moving on to cove


Book
Organ-on-a-chip
Authors: --- ---
ISBN: 0128172029 0128172037 9780128172032 9780128172025 Year: 2020 Publisher: London, United Kingdom

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