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Cocaine abuse remains a major public health problem and contributes to many of our most disturbing social problems, including the spread of infectious disease, crime, violence, and neonatal drug exposure. Cocaine abuse results from a complex interplay of behavioral, pharmacological, and neurobiological determinants. While a complete understanding of cocaine abuse is currently beyond us, significant progress has been made in preclinical research on fundamental determinants of this disorder. These advances are critically reviewed in the first section of this volume. Important advances also have

Cocaine abuse --- Cocaine --- Behavior --- Cocaine-Related Disorders --- Cocaine. --- Pathophysiology. --- Treatment. --- Psychological aspects. --- drug effects. --- pharmacology. --- therapy. --- Psychopharmacology --- Cocaine addiction --- Cocaine habit --- Crack abuse --- Crack addiction --- Drug abuse --- Physiological aspects. --- Drug effects. --- Pharmacology. --- Therapy.