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Book
The biology of oligodendrocytes
Authors: ---
ISBN: 9780521899659 9780511782121 9780511902321 0511902328 9780511799174 0511799179 9780511901539 0511901534 0511782128 0521899656 9786612817977 6612817976 1107212472 0511850743 1282817973 0511900740 051179777X Year: 2010 Publisher: Cambridge ; New York : Cambridge University Press,

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Abstract

Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.

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