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ASTHMA --- HYPERSENSITIVITY --- Hypersensitivity. --- Asthma. --- Asthma, Bronchial --- Bronchial Asthma --- Asthmas --- Bronchial Hyperreactivity --- Allergic Reaction --- Allergy --- Allergic Reactions --- Allergies --- Hypersensitivities --- Reaction, Allergic --- Reactions, Allergic --- Hypersensitivity --- Asthma

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Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes.  While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract.   Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum.    This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.

Skin --- Medical genetics. --- Evidence-based medicine. --- Diseases --- Genetic aspects. --- EBM (Medicine) --- Evidence-based healthcare --- Clinical medicine --- Systematic reviews (Medical research) --- Clinical genetics --- Heredity of disease --- Human genetics --- Medical sciences --- Pathology --- Genetic disorders --- Genodermatology --- Genodermatoses --- Decision making --- Genetic aspects --- Dermatology. --- Allergy. --- Pneumology. --- Ophthalmology. --- Allergology. --- Pneumology/Respiratory System. --- Medicine --- Eye --- Allergic diseases --- Allergies --- Hypersensitivity --- Hypersensitivity, Immediate --- Immediate allergy --- Immediate hypersensitivity --- Immunologic diseases --- Immunoglobulin E --- Respiratory organs—Diseases.

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Allergens --- Insects --- Poisonous arthropoda --- Arthropod Venoms --- Hypersensitivity --- Insect Bites and Stings --- #WDIR:wbse --- Insect venom --- Allergic Reaction --- Allergy --- Allergic Reactions --- Allergies --- Hypersensitivities --- Reaction, Allergic --- Reactions, Allergic --- Arachnid Venom --- Arthropod Venom --- Arachnid Toxin --- Arachnid Toxins --- Arachnid Venoms --- Hymenoptera Venom --- Hymenoptera Venoms --- Insect Venom --- Insect Venoms --- Toxin, Arachnid --- Toxins, Arachnid --- Venom, Arachnid --- Venom, Arthropod --- Venom, Hymenoptera --- Venom, Insect --- Venoms, Arachnid --- Venoms, Arthropod --- Venoms, Hymenoptera --- Venoms, Insect --- Allergen --- Pollen --- Arthropod venom --- Arthropoda --- Insect Bites --- Insect Stings --- Bite, Insect --- Bites, Insect --- Insect Bite --- Insect Sting --- Sting, Insect --- Stings, Insect --- Antigens --- Venom --- Allergens. --- Arthropod Venoms. --- Insect Bites and Stings. --- Hypersensitivity. --- Venom. --- Insects - Venom. --- Poisonous arthropoda - Venom.

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Immunology is a diverse and growing discipline that can be defined as the study of the tissues, cells and molecules involved in host defence mechanisms, how the body defends itself against disease, and what happens when it all goes wrong. Nature Reviews Immunology provides in-depth coverage of this field, from fundamental mechanisms to translational aspects of basic research, and reviews the field’s most important developments. All Review and Perspective articles are carefully commissioned by the editors and written by leaders in the field. Articles are subject to rigorous peer review and provide high-quality and authoritative coverage of the field in each issue. Articles are carefully tailored by the editors to provide accessible information for non-specialists, and this is additionally enhanced with the use of Glossary terms and highlighted references. Each issue also contains Research Highlight articles – short pieces written by the editors that summarize the results from recent hot research papers.

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