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This open access book offers a comprehensive review of hepatocellular carcinoma (HCC) with a particular focus on the pathobiology and clinical aspects of the disease, including diagnosis and treatment. HCC is becoming one of the most common causes of cancer-related death worldwide. It is the fifth most common malignancy in men and the ninth in women, with an estimated 500,000 to 1 million new cases annually around the world. Independent of its cause, cirrhosis is considered a major clinical and histopathological risk factor for HCC development. Five percent of all cirrhotic patients develop HCC every year. Diagnostic tools for HCC include blood tests, high-quality imaging studies and liver biopsy. The treatment of HCC depends on the size and location of the HCC and includes surgical resection, liver transplantation, endovascular approaches, percutaneous ablation, and medical treatments. The book is organized into four parts – overview, diagnosis, management strategies, and recommendations – and aims to provide surgeons and clinicians with a valuable resource for complete and up-to-date research on the clinical aspects and management of HCC.
Surgery. --- Gastroenterology. --- Family medicine. --- Surgery. --- Gastroenterology. --- General Practice and Family Medicine. --- Hepatic resection --- Liver Transplantation --- Radioembolization --- Cirrhosis --- ALPPS --- Hepatic resection --- Liver Transplantation --- Radioembolization --- Cirrhosis --- ALPPS
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Sleeve gastrectomy (SG) is the most common bariatric procedure, accounting for more than 55% of all such surgeries performed worldwide. Obesity has become a major global problem that continues to spread in both developed and developing countries. While prevention of obesity is the best approach for the future, the current challenge is managing those who are already obese or morbidly obese, who constitute close to two thirds of the population in many countries, such as the US. Today, bariatric surgery is the only evidence-based treatment for morbid obesity with a low complication rate and acceptable results in the long-term for both weight loss and resolution of comorbidities. This book details all the approaches used in sleeve gastrectomy (SG), offering readers the tools needed to perform the perfect SG. Each chapter focuses on the clinical problems and the indications for the sleeve, and describes the technique step-by-step (including videos), the staplers, the different sizes of bougies, reinforcement of the sutures after the sleeve and the metabolic effects of surgery. The book also presents nontraditional SG techniques, such as the endoscopic approach, stapled sleeve and robotic technologies, discussing how to immediately identify complications and their treatment using endoscopy, laparoscopy and percutaneous image guided surgery. Further, it includes a chapter on revision surgery and revision procedures, not only from sleeve to other procedures, but also from other procedures to SG. The last section offers an overview of what the authors imagine the future holds for this bariatric procedure. The Perfect Sleeve Gastrectomy - A Clinical Guide to Evaluation, Treatment, and Techniques is an ideal reference resource for general surgeons, bariatric surgeons, endoscopists and gastroenterologists as well as researchers with an interest in obesity and its management. It also appeals to residents and fellows, dietitians, diabetes specialist, psychotherapists and hospital administrators and quality officers.
Surgery. --- Gastroenterology . --- Gastroenterology. --- Internal medicine --- Digestive organs --- Surgery, Primitive --- Medicine --- Diseases --- Gastrectomy. --- Gastric resection --- Stomach --- Surgery
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This book provides a complete guide to laparoscopic sleeve gastrectomy and the management of obesity. The chapters discuss guidelines for healthcare providers for the management of patients with obesity, the rationale behind choosing patients, performing the procedure in line with the patient’s condition, the perioperative period, postoperative requirements, and postoperative complications. This book aims to give readers an understanding of the surgical techniques involved in laparoscopic sleeve gastrectomy and the wider treatment options available. It is relevant to bariatric, metabolic, and general surgeons, physicians, clinical nutritionists as well as students.
Surgery. --- Endocrinology . --- Endocrinology. --- Internal medicine --- Hormones --- Surgery, Primitive --- Medicine --- Laparoscopic surgery --- Gastrectomy. --- Minimally invasive surgery --- MIS (Minimally invasive surgery) --- Operative laparoscopy --- Operative peritoneoscopy --- Surgical laparoscopy --- Endoscopic surgery --- Laparoscopy --- Gastric resection --- Stomach --- Surgery
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This richly illustrated volume describes the performance of total and subtotal gastrectomy with extended D2 lymphadenectomy by providing a detailed step-by-step guide to both manual and mechanical procedures. Gastric cancer is the fourth most commonly occurring cancer, and the second most common cancer-related cause of death worldwide, and surgery remains the only potentially curative treatment. Although several aspects of surgical management are still controversial, all guidelines for the treatment of curable gastric cancer recommend subtotal gastrectomy (for tumors located in the antrum and corpus) or total gastrectomy (for tumors located in the fundus) with extended D2 lymphadenectomy. Various technical tips and secrets are revealed that serve to simplify the procedure and simultaneously make it more effective: by rendering esophagojejunal and gastrojejunal anastomosis more secure, the risk of leakage is minimized. High-quality intraoperative color photographs and drawings covering all steps facilitate understanding of these complex operations and will prove an invaluable tool for surgeons, residents and professionals in the field.
Medicine & Public Health. --- Surgical Oncology. --- Abdominal Surgery. --- General Surgery. --- Oncology. --- Gastroenterology. --- Medicine. --- Cancer --- Abdomen --- Surgery. --- Médecine --- Gastroentérologie --- Cancérologie --- Chirurgie --- Abdomen_xSurgery. --- Cancer_xSurgery. --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Gastrectomy --- Stomach --- Surgery --- Gastric resection --- Abdominal surgery. --- Surgical oncology. --- Oncology . --- Internal medicine --- Digestive organs --- Tumors --- Surgery, Primitive --- Medicine --- Abdominal surgery --- Laparotomy --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Diseases --- Excision --- Treatment --- Gastroenterology .
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Morbid obesity is an epidemic as more than 2/3 of the United States population is obese and as such, has a high burden of weight-related co-morbid diseases. Bariatric surgery has proven to be effective and durable for treatment of severe obesity. Technological advances including applications of laparoscopy and endolumenal techniques have rapidly advanced this field. Data and outcomes examining treatments have also improved and as providers, we have a wide spectrum of therapeutic options to treat patients. As techniques and outcomes have evolved, access to a comprehensive yet focused resource regarding bariatric surgery is currently limited. The proposed textbook is designed to present a comprehensive and state-of the-art approach to the current and future status of Bariatric interventions, which has changed significantly since the first edition of the Manual. Updates in this version will include the rapidly expanding field of endoluminal bariatric procedures, with a focus on new devices and theories of mechanisms. New data regarding laparoscopic approaches to treat obesity, as well as improved longer-term data outcomes will be reviewed. Newer surgical approaches to treat metabolic disease and obesity are included, as well as proposed mechanisms of action and efficacy. Additional new sections include sections on the application of robotic technologies, special circumstances including transplantation and pregnancy, and telemedicine and social media in bariatric surgery. Sections will address the evolution in specific treatments available to patients, initial evaluation and selection of procedures for individual patients, the latest surgical and endoscopic techniques being employed to treat patients including data on outcomes, and future directions for therapy. In particular and unique amongst references, a major focus of this text will be on both the bariatric and metabolic bases of therapies and outcomes. The SAGES Manual A Practical Guide to Bariatric Surgery, Second Edition aligns with the new SAGES UNIVERSITY MASTERS Program. The Manual supplements the Bariatric Surgery Pathway from Competency to Proficiency to Mastery. Whether it’s for Biliary, Hernia, Colon, Foregut or Bariatric, the key technical steps for the anchoring bariatric procedures are highlighted in detail as well as what the reader needs to know to successfully submit a video clip to the SAGES Facebook Channels for technical feedback. Readers will also learn about how to count credits for Bariatric from the other Master Program Series, Guidelines, Top 21 Videos, Pearls, FLS, FES, FUSE, SMART and Annual SAGES Meeting. The Masters Program promotes lifelong deliberate learning. .
Obesity --- Gastrectomy. --- Surgery. --- Medicine. --- Gastroenterology. --- Rectum --- Medicine & Public Health. --- General Surgery. --- Colorectal Surgery. --- Surgery, Primitive --- Medicine --- Internal medicine --- Digestive organs --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Diseases --- Gastric resection --- Stomach --- Bariatric surgery --- Weight loss surgery --- Surgery --- Colon (Anatomy) --- Rectum—Surgery . --- Gastroenterology .
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This book is designed specifically to help equip new surgeons with the anatomical and technical knowledge to supplement hands on experience in minimally invasive colon and rectal surgery. There are multiple colorectal surgeries which distinctly lend themselves to the use of the laparoscopic approach. To assist the junior surgeon who is embarking on a career in surgery, expert surgeons and educators in the field of colon and rectal surgery from around the country authored the chapters included in this book. Chapters describe key elements of each surgery, including the order of surgery, when and how the surgeon created tension, rotated the patient, and optimized flow of the surgery. Chapters also contain tips and pitfalls that are not always explicitly presented when describing a surgical approach in order to provide readers with a diverse toolkit. Each chapter is also full of new illustrations that show the direction of traction, the line of dissection, and the anatomy of the colon. The illustrations also present tools in a color-coded format to clearly distinguish between the surgeon’s and the assistant’s tools. Laparoscopic Colectomy: A Step by Step Guide is a valuable resource to residents and junior attendings who wish to master laparoscopic colon and rectal surgery.
Colectomy. --- Colonic resection --- Colon (Anatomy) --- Surgery --- Rectum—Surgery . --- Surgery. --- Colorectal Surgery. --- General Surgery. --- Surgery, Primitive --- Medicine --- Cirurgia laparoscòpica --- Colostomia --- Anus artificial --- Anus contra natura --- Cirurgia colorectal --- Enterostomia --- Cirurgia mínimament invasiva --- Laparoscòpia operatòria --- Laparoscòpia quirúrgica --- Laparoscopia terapèutica --- MIS (Cirurgia invasiva mínima) --- Peritoneoscòpia quirúrgica --- Cirurgia endoscòpica --- Laparoscòpia
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This book contains the art and science in current standards of surgical treatment of pancreatic ductal adenocarcinoma. It explains the clinical role of surgical resection during multimodal treatment in patients with pancreatic ductal adenocarcinoma, novel surgical techniques including extended pancreatectomy and minimally invasive surgery, risk of cancer in IPMN, and the clinical importance of liquid biopsy.
Medicine --- Surgery --- unresectable pancreatic ductal adenocarcinoma --- conversion surgery --- early recurrence --- pancreatic neoplasm/analysis --- pancreatic neoplasm/surgery --- tumor location --- survival --- clinical staging --- branch duct intraductal papillary mucinous neoplasm --- risk factor --- malignancy --- meta-analysis --- laparoscopic --- pancreaticoduodenectomy --- pancreatic cancer --- borderline resectable --- neoadjuvant treatment --- chemoradiotherapy --- prognostic nutritional index --- isolated local recurrence --- pancreatectomy --- pancreatic remnant --- recurrence --- redo surgery --- pancreatic exocrine insufficiency --- adjuvant chemotherapy --- biliary drainage --- prehabilitation --- ERAS --- arterial resection --- total pancreatectomy --- neoadjuvant therapy --- pancreatic ductal adenocarcinoma --- surgical treatment --- technical advances --- pancreatic main duct dilatation --- intraductal papillary mucinous neoplasm --- high grade dysplasia --- invasive carcinoma --- pancreatic cystic neoplasm --- cell-free DNA --- mesopancreas --- superior mesenteric artery --- nerve and fibrous tissues --- lymph node dissection --- R0 resection --- unresectable pancreatic ductal adenocarcinoma --- conversion surgery --- early recurrence --- pancreatic neoplasm/analysis --- pancreatic neoplasm/surgery --- tumor location --- survival --- clinical staging --- branch duct intraductal papillary mucinous neoplasm --- risk factor --- malignancy --- meta-analysis --- laparoscopic --- pancreaticoduodenectomy --- pancreatic cancer --- borderline resectable --- neoadjuvant treatment --- chemoradiotherapy --- prognostic nutritional index --- isolated local recurrence --- pancreatectomy --- pancreatic remnant --- recurrence --- redo surgery --- pancreatic exocrine insufficiency --- adjuvant chemotherapy --- biliary drainage --- prehabilitation --- ERAS --- arterial resection --- total pancreatectomy --- neoadjuvant therapy --- pancreatic ductal adenocarcinoma --- surgical treatment --- technical advances --- pancreatic main duct dilatation --- intraductal papillary mucinous neoplasm --- high grade dysplasia --- invasive carcinoma --- pancreatic cystic neoplasm --- cell-free DNA --- mesopancreas --- superior mesenteric artery --- nerve and fibrous tissues --- lymph node dissection --- R0 resection
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Recent decades have seen remarkable advances in the treatment of upper gastrointestinal malignancies, i.e., adenocarcinoma and squamous cell carcinoma as well as gastrointestinal stromal and other rare tumors of the esophagus and stomach. While, historically, surgical resection has been the sole treatment for these tumors, multimodal therapies have meanwhile proven their efficacy. At present, pre- and postoperative chemotherapy and radiotherapy, targeted drug therapy, and stage-specific surgical approaches are all indispensable cornerstones of an individualized treatment for upper gastrointestinal malignancies. With such multimodal treatment, better outcomes comprising improved quality of life and prolonged survival have been achieved for patients. However, for many tumor entities and stages, the ideal combination and sequence of treatments is still being evaluated in clinical trials. Moreover, the value of novel approaches such as immunotherapy or robotic surgery remains a matter of research. In this Special Issue of Cancers, up-to-date original research, short communications, and comprehensive review articles on all modalities playing a role in the treatment of upper gastrointestinal malignancies have been published.
Public health & preventive medicine --- gastric cancer --- gastrectomy --- complications --- outcome --- survival --- lymph node ratio --- neoadjuvant chemotherapy --- conversion surgery --- cancer dormancy --- nuclear receptor NR2F1 --- clinical pathways --- gastric surgery --- oncological gastrectomy --- quality of care --- outcomes --- standardization --- adjuvant therapy --- gastrointestinal tract --- genetic diagnosis --- radiosensitivity --- mortality --- failure to rescue --- immunotherapy --- genetics --- esophageal cancer --- multidisciplinary --- gastric/gastroesophageal cancer --- perioperative chemotherapy --- overall survival --- relapse-free survival --- skeletal muscle index --- esophagectomy --- nutritional status --- sarcopenia --- esophageal anastomosis --- minimally invasive surgery --- induction chemotherapy --- chemo-radiotherapy --- neoadjuvant treatment --- esophageal squamous cell carcinoma --- multimodal treatment --- neoadjuvant chemoradiotherapy --- definitive chemoradiotherapy --- Lauren histotype --- gastrointestinal stromal tumor --- neuroendocrine tumor --- MALT lymphoma --- mucosal resection --- submucosal dissection --- GIST --- stomach --- neoadjuvant therapy --- imatinib --- organ preservation --- squamous cell esophageal cancer --- gastro-esophageal reflux disease --- Barrett's esophagus --- early adenocarcinoma of esophagus --- endoscopic submucosal dissection --- endoscopic mucosal resection --- gastric cancer --- gastrectomy --- complications --- outcome --- survival --- lymph node ratio --- neoadjuvant chemotherapy --- conversion surgery --- cancer dormancy --- nuclear receptor NR2F1 --- clinical pathways --- gastric surgery --- oncological gastrectomy --- quality of care --- outcomes --- standardization --- adjuvant therapy --- gastrointestinal tract --- genetic diagnosis --- radiosensitivity --- mortality --- failure to rescue --- immunotherapy --- genetics --- esophageal cancer --- multidisciplinary --- gastric/gastroesophageal cancer --- perioperative chemotherapy --- overall survival --- relapse-free survival --- skeletal muscle index --- esophagectomy --- nutritional status --- sarcopenia --- esophageal anastomosis --- minimally invasive surgery --- induction chemotherapy --- chemo-radiotherapy --- neoadjuvant treatment --- esophageal squamous cell carcinoma --- multimodal treatment --- neoadjuvant chemoradiotherapy --- definitive chemoradiotherapy --- Lauren histotype --- gastrointestinal stromal tumor --- neuroendocrine tumor --- MALT lymphoma --- mucosal resection --- submucosal dissection --- GIST --- stomach --- neoadjuvant therapy --- imatinib --- organ preservation --- squamous cell esophageal cancer --- gastro-esophageal reflux disease --- Barrett's esophagus --- early adenocarcinoma of esophagus --- endoscopic submucosal dissection --- endoscopic mucosal resection
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This book presents surgical techniques and detailed illustrations of laparoscopic gastrectomy for gastric cancer, focusing on effective, concise steps and techniques. It describes in detail the perigastric anatomy, and the incidences of each anatomical structure are analyzed statistically. It also discusses lessons learned and best practices in the management of gastric cancer patients, and includes video captures of precise operational techniques -essential resources for gastrointestinal laparoscopic surgeons. Given its close connection to clinical practice, it offers a valuable reference work for general surgeons and residents. Editor Chang-Ming Huang is a Professor at the Department of Gastric Surgery, Fujian Medical University Union Hospital, China. Editor Chao-Hui Zheng is an Associate Professor at the same department.
Medicine & Public Health. --- Surgical Oncology. --- Minimally Invasive Surgery. --- Gastroenterology. --- Medicine. --- Cancer --- Endoscopic surgery. --- Médecine --- Gastroentérologie --- Chirurgie endoscopique --- Surgery. --- Chirurgie --- Cancer_xSurgery. --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Gastrectomy. --- Stomach --- Gastric resection --- Minimally invasive surgery. --- Surgical oncology. --- Abdomen --- Gastrointestinal system --- Surgery --- Endosurgery --- Minimal access surgery --- Minimally invasive surgery --- MIS (Minimally invasive surgery) --- Operative endoscopy --- Surgical endoscopy --- Endoscopy --- Microsurgery --- Surgery, Operative --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Internal medicine --- Digestive organs --- Excision --- Treatment --- Diseases --- Gastroenterology .
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This Urological Cancer 2020 collection contains a set of multidisciplinary contributions to the extraordinary heterogeneity of tumor mechanisms, diagnostic approaches, and therapies of the renal, urinary tract, and prostate cancers, with the intention of offering to interested readers a representative snapshot of the status of urological research.
Research. --- Biology. --- renal cell carcinoma --- iron --- macrophages --- chelation therapy --- urothelial carcinoma --- transcriptome --- microtubule --- MAP1B --- prognosis --- KLF5 --- androgen receptor --- cell proliferation --- tumorigenesis --- prostate cancer --- precision medicine --- whole genome sequencing --- optical mapping --- therapy --- prostate carcinoma --- prostate mpMRI --- machine learning --- artificial intelligence --- deep learning --- neural network --- angiogenesis --- angiogenic growth factors --- antiangiogenic therapy --- renal tumors --- prevention --- α1-adrenoceptor antagonists --- anoikis --- vascularity --- research model --- oncogenes --- tumor suppressor genes --- MR-guided --- radiotherapy --- MRgRT --- stereotactic ablative radiotherapy --- stereotactic ablative radiation therapy (SABR) --- renal cell cancer --- RCC --- online adaptive --- [68Ga]Ga-PSMA PET/CT --- dual-time point imaging --- delayed imaging --- biphasic imaging --- lesion positivity rate --- CXCL9 --- PD1 --- PD-L1 --- stage T1 NMIBC --- prostatic neoplasms/mortality --- prostatic neoplasms/epidemiology --- SEER Program --- bladder cancer --- transurethral resection --- en-bloc resection --- CPT1A --- fatty acids --- serine --- androgen response --- ROS --- oxidative stress --- DONSON --- Downstream Neighbor of SON --- biomarker --- metastatic spread --- diagnosis --- differential diagnosis --- histopathology --- immunohistochemistry --- stroma signature --- patient-derived xenografts --- renal cell carcinoma --- iron --- macrophages --- chelation therapy --- urothelial carcinoma --- transcriptome --- microtubule --- MAP1B --- prognosis --- KLF5 --- androgen receptor --- cell proliferation --- tumorigenesis --- prostate cancer --- precision medicine --- whole genome sequencing --- optical mapping --- therapy --- prostate carcinoma --- prostate mpMRI --- machine learning --- artificial intelligence --- deep learning --- neural network --- angiogenesis --- angiogenic growth factors --- antiangiogenic therapy --- renal tumors --- prevention --- α1-adrenoceptor antagonists --- anoikis --- vascularity --- research model --- oncogenes --- tumor suppressor genes --- MR-guided --- radiotherapy --- MRgRT --- stereotactic ablative radiotherapy --- stereotactic ablative radiation therapy (SABR) --- renal cell cancer --- RCC --- online adaptive --- [68Ga]Ga-PSMA PET/CT --- dual-time point imaging --- delayed imaging --- biphasic imaging --- lesion positivity rate --- CXCL9 --- PD1 --- PD-L1 --- stage T1 NMIBC --- prostatic neoplasms/mortality --- prostatic neoplasms/epidemiology --- SEER Program --- bladder cancer --- transurethral resection --- en-bloc resection --- CPT1A --- fatty acids --- serine --- androgen response --- ROS --- oxidative stress --- DONSON --- Downstream Neighbor of SON --- biomarker --- metastatic spread --- diagnosis --- differential diagnosis --- histopathology --- immunohistochemistry --- stroma signature --- patient-derived xenografts
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