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book (9)


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Book
Blood-Derived Products for Tissue Repair/Regeneration
Authors: ---
ISBN: 3039218611 3039218603 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.


Book
Actualités en médecine régénérative musculosquelettique
Authors: --- --- --- --- --- et al.
ISBN: 9791030304237 Year: 2024 Publisher: Montpellier: Sauramps Médical,

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Ce deuxième ouvrage du GRIIP (Groupe de Recherche International sur les Injections de Plaquettes) inaugure une collection ayant pour thème "les actualités en médecine régénératrice musculosquelettique" que nous espérons renouveler chaque année, tant cette nouvelle branche de la médecine se développe et est promise à un bel avenir. Cela souligne que notre groupe ne se limite pas aux PRP, mais à l'ensemble des thérapies novatrices visant à favoriser la réparation la plus naturelle possible des lésions de l'appareil locomoteur, cartilage, tendon, ligament, rétinaculum, muscle et os induites principalement par l'âge, la génétique, les traumatismes, la sursollicitation, les maladies inflammatoires, métaboliques ou infectieuses. Le premier livre a rencontré un grand succès justifiant une réédition et nous espérons que cette collection débutante deviendra un outil utile à tous les médecins des nombreuses spécialités impliquées dans la prise en charge de ces pathologies si fréquentes, mais aussi aux paramédicaux, biologistes, et pharmaciens concernés par ces traitement. La transversalité de notre groupe est illustrée par la participation de rhumatologues, MPR et physiatres, médecins du sport, chirurgiens orthopédistes, radiologues, biologistes et chercheurs à la rédaction de ces divers chapitres où le lecteur trouvera de belles mises au point sur les traitements injectables au pied et à la cheville et dans la capsule rétractile, les stratégies pour stimuler la réparation tendineuse, le PRF, le PRP en pathologie ligamentaire et les diverses formulations d'acide hyaluronique injectable. Des aspects plus fondamentaux ou techniques sont aussi abordés avec les facteurs de croissance, l'aphérèse, l'utilisation de la moelle osseuse dans la gonarthrose et d'autres cellules souches mésenchymateuses dans les tendinopathies. Nous avons aussi inauguré des communications originales montrant le dynamisme de cette médecine, avec les exosomes, l'association PRP/toxine botulique, l'impact de l'environnement tissulaire, les injections de haut volume, la micrograisse, tous sujets qui feront l'objet de débats passionnants lors de la deuxième journée du GRIIP. Organiser une telle journée et éditer chaque année un livre que l'on espère utile et passionnant ne se fait pas sans un immense travail et nous remercions chaleureusement les auteurs, les relecteurs, les correcteurs et notre éditeur de leur implication sans faille.


Book
Electrospun Nanomaterials : Applications in Food, Environmental Remediation, and Bioengineering
Authors: ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

The papers collected in this Special Issue entitled “Electrospun Nanomaterials: Applications in Food, Environmental Remediation, and Bioengineering” illustrate the high diversity and potential for implementation of electrospun nanofibers in these fields, including the covering of a wide number of subtopics. Examples of these applications have included bioactive scaffolds, wound healing dressings, compound protective nanoreservoirs and sustained and controlled release systems. An important driver of these applications results from advances in materials science and new nanofiber manufacturing processes. Definitely, such pieces of fundamental research will contribute to the promotion of electrospinning as a focal point in the future development of technological applications at the interface of biological systems, which promise long-term benefits for both health and the environment.


Book
Stem Cell and Biologic Scaffold Engineering
Author:
ISBN: 3039214985 3039214977 9783039214983 Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.


Book
Recent Research of Carpal Tunnel Syndrome
Author:
ISBN: 3036558004 3036557997 Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Carpal tunnel syndrome (CTS) is a very common median nerve compression neuropathy at wrist level. It causes unplesant symptoms to patient as well as a financial burden for society. Conservative treatment helps with mild and transient symptoms, but often this syndrome requires surgical treatment. Surgical decompression of the median nerve is one of the most common surgical operations. If the symptom persists for a long time and treatment is delayed, this can result in a lack of sensation in the median area in addition to thenar atrophy and weakness of the thumb opposition. There are many impressive things behind CTS that we do not know yet; anatomical causes, links to other diseases and medication, occupational exposures and predisposing lifestyle risk factors. Diagnostics and differential diagnostics of CTS have their own challenges. Conservative treatment practices of CTS are diverse and unambiguous best practice is not clear. Clinical symptoms, electromyography (EMG) finding, and possible differential diagnostic challenges should be considered when deciding on surgery. Surgical treatment varies somewhat from hospital to hospital and from country to country. When the CTS diagnosis and treatment is done too late for nerves to recover or there is perioperative complication, some late reconstructive surgeries might be needed. These nerve surgery techniques can be done by experienced hand surgeons. The quality of care, complications, and cost effectiveness of different methods require further research. This Special Issue will present the latest research on this interesting and clinically significant syndrome.


Book
Personalized Medicine in the Field of Inflammatory Skin Disorders
Authors: --- --- ---
Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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Skin inflammation is associated with a wide range of conditions which represent major health issues worldwide. Skin and mucosal surfaces represent the primary interface between the human body and the environment, susceptible to numerous factors whose action results in diseases produced by chemical substances, mechanical trauma, microbial agents, radiation, etc. Inflammation, a complex network of interactions between soluble molecules and cells, represents the main modality of the skin’s response to injuries. Numerous studies have revealed close links between chronic inflammation, oxidative stress, and carcinogenesis. Chronic inflammation induces the activation of various cell types and an increase in the production of reactive oxygen species, promoting the initiation of a malignant process. Identifying specific biomarkers is essential for understanding molecular mechanisms and developing therapies appropriate to the patient’s characteristics.Personalized medicine is an emerging field of medicine that has the potential to predict which therapy will be safe and efficacious for specific patients using an individual’s genetic profile to guide decisions regarding the diagnosis, treatment, as well as prevention of disease. This book gathers articles that present recent advancements in research involving the mechanisms that underlie the development of inflammatory skin disorders, skin and mucosal inflammation in general.

Keywords

Medicine --- sea-buckthorn seed oil --- long-chain fatty acids --- skin dysplastic keratinocytes --- UVA --- CD36 --- SR-B2 --- atopic dermatitis --- eczema --- JAK inhibitors --- systematic review --- meta-analysis --- evidence-based medicine --- immune-mediated skin diseases --- target therapy --- skin conditions and systemic inflammatory diseases --- systemic sclerosis --- biomarker --- calumenin --- S100A6 --- cytohesin 2 --- cannabinoids --- inflammation --- gut-lung-skin barrier --- signaling pathways --- inflammatory biomarkers --- psoriasis vulgaris --- prevalence --- comorbidities --- risk factors --- systemic lupus erythematous --- lupus nephritis --- lipid peroxidation --- DNA oxidation --- oxidized proteins --- carbohydrate oxidation --- antioxidative stress strategies --- biomarkers --- IgY --- psoriatic dermatitis --- imiquimod --- C57 BL/6 mice --- alginate --- biomaterial --- dressing --- fibers --- hydrogel --- nanofibers --- commercially available --- wound care --- wound healing --- cutaneous melanoma --- epigenetic regulation --- drug resistance --- therapeutic targets --- epigenetic therapy --- immune response --- Sutton nevi --- halo nevi --- skin tumor --- psoriasis --- proteome analysis --- estrogen --- menopause --- cSCC --- AK --- sialylation --- sialyltransferase --- sialidase --- COVID-19 --- pyoderma gangrenosum --- immunosuppression --- cyclosporine --- corticosteroids --- autoinflammatory disease --- androgenic alopecia --- clinical trial --- hair density --- platelet-rich plasma


Book
3D Stem Cell Culture
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Recently, stem cells have been drawing increasing interest in basic and translational research that aims to understand stem cell biology and generate new therapies for various disorders. Many stem cells can be cultured in 2D relatively easily using tissue culture plastic. However, many of these cultures do not represent the natural conditions of stem cells in the body. In the body, microenvironments include numerous supporting cells and molecules. Therefore, researchers and clinicians have sought ideal stem cell preparations for basic research and clinical applications, which may be attainable through 3D culture of stem cells. The 3D cultures mimic the conditions of the natural environment of stem cells better, as cells in 3D cultures exhibit many unique and desirable characteristics that could be beneficial for therapeutic interventions. 3D stem cell cultures may employ supporting structures, such as various matrices or scaffolds, in addition to stem cells, to support complex structures. This book brings together recent research on 3D cultures of various stem cells to increase the basic understanding of stem cell culture techniques and also to highlight stem cell preparations for possible novel therapeutic applications.


Book
Muscle Homeostasis and Regeneration : From Molecular Mechanisms to Therapeutic Opportunities
Author:
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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The book is a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration. One of the most ambitious aspirations of modern medical science is the possibility of regenerating any damaged part of the body, including skeletal muscle. This desire has prompted clinicians and researchers to search for innovative technologies aimed at replacing organs and tissues that are compromised. In this context, the papers, collected in this book, addressing a specific aspects of muscle homeostasis and regeneration under physiopathologic conditions, will help us to better understand the underlying mechanisms of muscle healing and will help to design more appropriate therapeutic approaches to improve muscle regeneration and to counteract muscle diseases.

Keywords

Research & information: general --- Biology, life sciences --- lysine --- mTORC1 --- satellite cells --- proliferation --- skeletal muscle growth --- muscle satellite cell --- transthyretin --- thyroid hormone --- myogenesis --- exosomes --- skeletal muscle --- genotype --- genetic variation --- muscle phenotypes --- sarcopenia --- aging --- calcium homeostasis --- hibernation --- mitochondria --- sarcoplasmic reticulum --- Acvr1b --- Tgfbr1 --- myostatin --- Col1a1 --- fibrosis --- atrophy --- IGF2R --- muscle homeostasis --- inflammation --- muscular dystrophy --- pericytes --- macrophages --- Nfix --- phagocytosis --- RhoA-ROCK1 --- splicing isoforms --- CRISPR-Cas9 --- exon deletion --- NF-Y --- muscle differentiation --- C2C12 cells --- denervation --- neuromuscular junction --- heavy resistance exercise --- acetylcholine receptor --- cell culture --- neonatal myosin --- neural cell adhesion molecule --- biomarkers --- mitophagy --- mitochondrial dynamics --- mitochondrial quality control --- mitochondrial-derived vesicles (MDVs) --- mitochondrial-lysosomal axis --- Hibernation --- electron microscopy --- immunocytochemistry --- α-smooth muscle actin --- confocal microscopy --- connexin 43 --- connexin 26 --- gap junctions --- myofibroblasts --- Platelet-Rich Plasma --- transforming growth factor (TGF)-β1 --- muscle regeneration --- inflammatory response --- cell precursors --- experimental methods --- stem cell markers --- muscles --- heterotopic ossification --- skeletal muscle stem and progenitor cells --- HO precursors --- muscle atrophy --- septicemia --- mitochondrial fusion --- mitochondrial fission --- iPSC --- extracellular vesicles --- Drosophila --- muscle --- genetic control --- muscle diversification --- fascicle --- myofiber --- myofibril --- sarcomere --- hypertrophy --- hyperplasia --- splitting --- radial growth --- longitudinal growth --- exercise --- muscle stem cells --- stem cells niche --- neuromuscular disorders --- Duchenne muscular dystrophy --- pharmacological approach --- single-cell --- mass cytometry --- skeletal muscle regeneration --- skeletal muscle homeostasis --- fibro/adipogenic progenitors --- myogenic progenitors --- muscle populations --- evolution --- metazoans --- differentiation --- transdifferentiation --- muscle precursors --- regenerative medicine --- stem cells --- FAPs --- tissue niche --- growth factors --- muscle pathology


Book
Recent Advances in Minimally Invasive Surgery
Authors: ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Minimally invasive surgery has become a common term in visceral as well as gynecologic surgery. It has almost evolved into its own surgical speciality over the past 20 years. Today, being firmly established in every subspeciality of visceral surgery, it is now no longer a distinct skillset, but a fixed part of the armamentarium of surgical options available. In every indication, the advantages of a minimally invasive approach include reduced intraoperative blood loss, less postoperative pain, and shorter rehabilitation times, as well as a marked reduction of overall and surgical postoperative morbidity. In the advent of modern oncologic treatment algorithms, these effects not only lower the immediate impact that an operation has on the patient, but also become important key steps in reducing the side-effects of surgery. Thus, they enable surgery to become a module in modern multi-disciplinary cancer treatment, which blends into multimodular treatment options at different times and prolongs and widens the possibilities available to cancer patients. In this quickly changing environment, the requirement to learn and refine not only open surgical but also different minimally invasive techniques on high levels deeply impact modern surgical training pathways. The use of modern elearning tools and new and praxis-based surgical training possibilities have been readily integrated into modern surgical education,which persists throughout the whole surgical career of modern gynecologic and visceral surgery specialists.

Keywords

Medicine --- ovarian cancer --- laparoscopy --- minimally invasive surgery --- survival --- mortality --- platelet-rich plasma (PRP) --- thin endometrium --- hysteroscopy --- robotic surgery --- sexuality --- laparoscopic hysterectomy --- learning curve --- quality of life --- counseling --- patient-doctor-relationship --- body donors --- surgical education --- clinical anatomy --- live surgery events --- neuropelveology --- LION procedure --- genital nerves stimulation --- chronic pelvic pain --- esophagectomy --- esophageal cancer --- Ivor-Lewis procedure --- health-related quality of life --- cervical cancer --- robotic radical hysterectomy --- recurrence rate --- surgery --- artificial intelligence --- machine learning --- augmented reality --- hysterectomy --- NOTES --- minimally invasive --- systematic review --- meta-analysis --- pediatric surgery --- fetal surgery --- single-incision surgery --- surgical techniques --- surgical devices --- open surgery --- endoscopy --- endoscopic surgery --- cysts of the canal of Nuck --- Nuck hydrocele --- hydrocelectomy --- TAPP --- Lichtenstein --- colorectal liver metastases --- laparoscopic liver surgery --- minimal invasive surgery --- general anesthesia --- anesthetics --- perioperative care --- laparoscopic surgery --- endometrial cancer --- lymphadenectomy --- embryology --- sentinel lymph node mapping --- indocyanine green --- PMMR --- technical aspects --- rectal cancer --- mesorectal --- transanal --- laparoscopic --- local recurrence --- conversion rate --- minimally invasive surgical procedures --- radiotherapy --- ovarian neoplasms --- endometrial neoplasms --- uterine cervical neoplasms --- vaginal neoplasms --- vulvar neoplasms --- survival analysis --- video feedback --- video modeling --- gynecology --- surgical training --- pelvitrainer --- prolapse --- pelvic floor --- native tissue --- pectopexy --- robotic assisted surgery --- pancreatic surgery --- pancreaticoduodenectomy --- pelvic floor repair --- laparoscopic repair --- vaginal repair --- mesh use --- VATS --- pain --- postoperative pain control --- thoracic surgery --- lung cancer --- intercostal catheter --- opioid --- regional anaesthesia --- hepatectomy --- single-port laparoscopy --- radiofrequency pre-coagulation --- endometriosis --- endometrioma surgery --- ovarian reserve --- anti-Müllerian hormone --- spontaneous pregnancy --- robotic liver resection --- da Vinci --- intraoperative imaging --- hepatocellular cancer --- real-life imaging --- hepatic metastasis --- COVID-19 --- sars-cov-2 --- surgical performance --- 3D printing --- skill assessment --- snorkel mask --- malabsorption --- Roux-en-Y gastric bypass --- one-anastomosis gastric bypass --- SADI-S --- biliopancreatic diversion --- weight regain --- hepatocellular carcinoma --- cholangiocarcinoma --- risk score --- pelvic compartments --- embryologic development --- oncologic surgery --- pelvic lymphonodectomy --- topographic anatomy --- autonomic pelvic nerves --- uterine cancer --- prostate cancer --- diaphragmatic hernia --- liver resection --- hernia repair --- mesh --- enterothorax

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