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Studies focusing on the perinatal period face unique challenges, yet research in this area is extremely important, as this period of life is highly delicate and adverse events might have a long-lasting impact. With the advent of powerful high-resolution and high-throughput analytical methods, researchers have started to successfully develop and implement novel approaches in this area. New insights have great potential to be translated into novel diagnostic tools, as well as alternative preventive and treatment approaches. This book collects a series of timely review and original research articles focusing on metabolomic, oxidative, and nitrosative stress in the perinatal period.We would like to thank all involved authors for their high-quality contributions and their commitment to the publication of this work and hope that this book will be a useful resource for students, scientists, and doctors working in this specific area of application.

Medicine --- glutathione --- glutamate --- oxidative stress --- hypoxia ischemia --- endotoxin --- magnetic resonance spectroscopy --- N-acetylcysteine --- vitamin D --- neonatal HIE --- MRS --- preterm birth --- sex differences --- male disadvantage --- female advantage --- bronchopulmonary dysplasia --- retinopathy of prematurity --- necrotizing enterocolitis --- intraventricular hemorrhage --- periventricular leukomalacia --- mortality --- transposition of the great arteries --- balloon atrial septostomy --- hypoxemia --- metabolomics --- newborn --- liquid chromatography-mass spectrometry (LC-MS) --- allopurinol --- hypothermia --- hypoxic-ischemic encephalopathy --- oxidative damage --- donor milk --- treatment --- Holder pasteurization --- breastmilk --- preterm --- antioxidant capacity --- asphyxia neonatorum --- non-invasive diagnostics --- saliva --- neonatal hypoxia-ischemia --- kynurenic acid (KYNA) --- neuroprotection --- hyperoxia --- prematurity --- glutathione --- glutamate --- oxidative stress --- hypoxia ischemia --- endotoxin --- magnetic resonance spectroscopy --- N-acetylcysteine --- vitamin D --- neonatal HIE --- MRS --- preterm birth --- sex differences --- male disadvantage --- female advantage --- bronchopulmonary dysplasia --- retinopathy of prematurity --- necrotizing enterocolitis --- intraventricular hemorrhage --- periventricular leukomalacia --- mortality --- transposition of the great arteries --- balloon atrial septostomy --- hypoxemia --- metabolomics --- newborn --- liquid chromatography-mass spectrometry (LC-MS) --- allopurinol --- hypothermia --- hypoxic-ischemic encephalopathy --- oxidative damage --- donor milk --- treatment --- Holder pasteurization --- breastmilk --- preterm --- antioxidant capacity --- asphyxia neonatorum --- non-invasive diagnostics --- saliva --- neonatal hypoxia-ischemia --- kynurenic acid (KYNA) --- neuroprotection --- hyperoxia --- prematurity

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This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.

Cancer. --- Cancer—Treatment. --- Tumors—Immunological aspects. --- Cancers. --- Cancer Therapy. --- Cancer Biology. --- Tumour Immunology. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Tumor Hypoxia. --- Hypoxia. --- Cell Hypoxia. --- Neoplasms --- immunology. --- therapy. --- Anoxia, Cellular --- Cell Anoxia --- Hypoxia, Cellular --- Anoxia, Cell --- Anoxias, Cell --- Anoxias, Cellular --- Cell Anoxias --- Cell Hypoxias --- Cellular Anoxia --- Cellular Anoxias --- Cellular Hypoxia --- Cellular Hypoxias --- Hypoxia, Cell --- Hypoxias, Cell --- Hypoxias, Cellular --- Anoxemia --- Deficiency, Oxygen --- Hypoxemia --- Anoxia --- Oxygen Deficiency --- Deficiencies, Oxygen --- Oxygen Deficiencies --- Oxygen --- Altitude Sickness --- Atmospheric Pressure --- Hypoxia-Ischemia, Brain --- Tumor Cell Hypoxia --- Cell Hypoxia, Tumor --- Cell Hypoxias, Tumor --- Hypoxia, Tumor --- Hypoxia, Tumor Cell --- Hypoxias, Tumor --- Hypoxias, Tumor Cell --- Tumor Cell Hypoxias --- Tumor Hypoxias --- deficiency --- Anoxemia. --- Anoxaemia --- Anoxhemia --- Hypoxia (Hematology) --- Oxygen deficiency in the blood --- Altitude, Influence of --- Asphyxia --- Oxygen in the body --- Physiological effect