Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.

Gluten-free diet. --- Celiac disease --- Diet therapy

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Gluten Related Disorders: People Shall not Live on Bread Alone

Non Celiac Gluten Sensitivity --- Food Sensitivities --- Celiac Disease --- Gluten Related Disorders --- Gluten-Free Diet

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Among gluten-related disorders, coeliac disease (CD) is the best-known one to date, a chronic immune-mediated enteropathy triggered by exposure to gluten in genetically predisposed individuals. It is a common disease, occurring at all ages and characterized by a wide spectrum of clinical manifestations, affecting any organ or tissue. The diagnosis rate of this pathology has increased in the last 10 years, so worldwide epidemiologic data are now available that show that CD is ubiquitous, with a prevalence of 1.4%, higher in female than male individuals. Currently, the only effective treatment for CD is strict and lifelong adherence to a gluten-free diet (GFD). However, CD research is changing rapidly due to the continuous advancing of knowledge. For this reason, the main goal of this Special Issue has been to address the existing knowledge gaps and help advance such important aspects as the pathophysiology, diagnosis, follow-up, and therapeutic options of this pathology. This Special Issue includes 12 peer-reviewed articles reporting on the latest research findings in and evidence related to CD. The published articles cover a range of topics central to CD and GFDs.

Medicine --- celiac disease --- relatives --- microbiota --- Saccharomyces cerevisiae --- Pseudomonas fluorescens --- Bacteroides caccae --- coeliac disease --- oral diseases --- oral prevention --- gingival bleeding --- sleep-related breathing disorders --- oral health --- enamel defects --- interceptive orthodontics --- data mining gluten free diet --- gluten proteins --- immunogenicity --- evidence-based practice --- case management --- treatment adherence and compliance --- anemia --- iron transporter --- IgA nephropathy --- tissue transglutaminase autoantibody --- tissue transglutaminase-targeted IgA deposits --- flow cytometry --- age --- sex --- lesion grade --- intraepithelial lymphocytes TCRγδ+ --- functional bowel disease --- gluten-free diet --- tissue biomarkers --- non-coeliac gluten sensitivity --- FODMAP diet --- dietitian --- rural health services --- gluten --- gliadin --- gluten immunogenic peptides --- non-dietary therapies --- gluten cross-contaminations --- dietary adherence --- vital gluten --- oat --- hidden gluten --- patients with CD --- symptoms --- gluten excretion urine --- gluten-free diet monitoring --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The only effective and safe treatment of celiac disease (CD) is a lifelong, strict exclusion of gluten, the so-called gluten-free diet (GFD). As a consequence, strict adherence to the GFD is highly successful and useful to achieve optimal control of symptoms in celiac patients, although, sometimes, nutritional problems can persist despite a strict exclusion of gluten. However, following a strict GFD is not easy and an updated quality assessment of available products is needed for further improvement in gluten-free product development. Similar to CD, GFD is the common dietary approach in non-celiac gluten/wheat sensitivity (NCGWS). NCGWS is another common gluten-related disorder without the diagnostic features of CD. Increasing interest in the association and interaction between irritable bowel syndrome (IBS), functional dyspepsia, and gluten-related disorders can expand our knowledge and understanding of the management of these disorders. In this respect, GFD is considered a therapeutic option in IBS and functional digestive disorders. New insights into the GFD are an exciting scientific challenge for researchers.

Research & information: general --- Biology, life sciences --- Food & society --- irritable bowel syndrome --- celiac disease --- nonceliac gluten/wheat sensitivity --- gluten-free diet --- AIDAI score --- amylase trypsin inhibitor --- non-celiac wheat sensitivity --- CD14 lymphocytes --- interleukin-1beta --- tumor necrosis factor-α --- non coeliac wheat sensitivity --- gluten --- FODMAPs --- functional dyspepsia --- Celiac disease --- iron deficiency without anemia --- dietary iron --- iron supplementation --- women --- refractory celiac disease --- remission --- nickel allergy --- allergic contact mucositis --- irritable bowel syndrome (IBS) --- low-nickel diet --- gluten-free products --- gluten containing products --- food composition database --- dietary reference intake --- prison diets --- irritable bowel disease --- FODMAP --- low FODMAP diet --- gluten free diet --- non-celiac gluten wheat sensitivity

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The extraintestinal manifestations of coeliac disease (CD) are now well recognised. We have previously edited a special issue for Nutrients covering all aspects of the extraintestinal manifestations in the context of CD. In this issue we wish to concentrate just on the neurological manifestations. The identification of TG6 autoantibodies in patients with neurological manifestations and its use in the diagnosis of such patients seems to be a good opportunity to focus on the neurological aspect of CD. In addition it is now clear that such manifestations can occur even in the absence of enteropathy but in the presence of antigliadin antibodies and/or TG6 antibodies. Given that such antigliadin antibodies can be found in up to 10% of the “healthy” population we anticipate that the neurological manifestations are likely to be very common and thus merit early recognition and treatment.

Research & information: general --- Biology, life sciences --- Food & society --- coeliac disease --- gluten free diet --- psychiatric manifestations --- autistic spectrum disorder --- attention deficit hyperactivity disorder --- depression --- anxiety --- bipolar disorder --- schizophrenia --- eating disorders --- gluten --- neurological disorders --- gliadin --- ataxia --- neuropathy --- myopathy --- encephalopathy --- food intolerance --- celiac disease --- gluten sensitivity --- gluten-free diet --- cognition --- neurology --- disease duration --- autoimmunity --- multiple sclerosis --- psoriasis --- autoimmune thyroid disease --- type 1 diabetes --- transglutaminase antibodies --- TG2 --- TG3 --- TG6 --- dermatitis herpetiformis --- gluten ataxia --- gluten encephalopathy --- gluten neuropathy --- autism spectrum disorder --- review --- stiff person syndrome --- anti-GAD antibodies --- cerebellar ataxia --- gluten-related pathology --- cortical excitability --- transcallosal inhibition --- transcranial magnetic stimulation --- executive dysfunction --- gamma-amino-butyric acid --- neurological dysfunction --- headaches --- anti-gliadin antibodies --- MR imaging --- TG6 antibodies --- non-celiac wheat sensitivity --- irritable bowel syndrome --- multiple food hypersensitivity --- neuropsychiatric symptoms --- HLA --- duodenal lymphocytosis