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The definitive reference for space engineers on rendezvous and docking/berthing (RVD/B) related issues, this book answers key questions such as: How does the docking vehicle accurately approach the target spacecraft? What technology is needed aboard the spacecraft to perform automatic rendezvous and docking, and what systems are required by ground control to supervise this process? How can the proper functioning of all rendezvous-related equipment, systems and operations be verified before launch? The book provides an overview of the major issues governing approach and mating strategies, and system concepts for rendezvous and docking/berthing. These issues are described and explained such that aerospace engineers, students and even newcomers to the field can acquire a basic understanding of RVD/B. The author would like to extend his thanks to Dr Shufan Wu, GNC specialist and translator of the book's Chinese edition, for his help in the compilation of these important errata.

Orbital rendezvous (Space flight) --- Space vehicles --- 629.78 --- Docking of space vehicles --- Space vehicle docking --- Aerospace engineering --- Space rockets --- Spacecraft --- Spaceships --- Astronautics --- Navigation (Astronautics) --- Rocketry --- Vehicles --- Rendezvous, Orbital --- Rendezvous (Space) --- Rendezvous in space --- Space orbital rendezvous --- Space flight --- Space ships --- Space stations --- Automatic control --- Docking --- Ruimteschip --- Piloting --- Orbital rendezvous (Space flight). --- Mechanical Engineering --- Engineering & Applied Sciences --- Aeronautics Engineering & Astronautics --- Automatic control. --- Docking.

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This thesis work is focusing on the design and analysis of a Floating Dry Dock complying with DNV-GL Rules with emphasis on the structural design and stability. The mentioned work was carried out during the internship in Nelton Sp. z o.o. located in Szczecin from July 3 till November 8 in the year 2017. 
Floating Dry Docks are being widely used for the construction of ships, docking of ships for inspection and repairs and also for ship launching. One of the major advantage of floating dry docks from the graving docks is mobility. And a floating dry dock doesn’t require any yard space. Floating dry docks are built to different lifting capacities, and there are different types of designs available as well based on the requirements. With the requirement for a pontoon type floating dry dock with 5 modules of pontoons and 2 dock wings which can be dismantled, the design is carried out for the same with an appropriate connection between the pontoons and the wing tanks. 
Just like any other structure, the safety is of prime concern and hence various classification societies developed rules for the design of floating dry docks with regard to the structural design, stability, machinery, other safety and protection systems and survey requirements. Current work is based on the rules developed by DNV-GL. 
With a stability check based on approximated weights available, the work carried out involves the global structural design, with adequate connections between different modules. With structural design in place, more or less actual weights of the structure is calculated and then the stability check is done based on that. Based on a feasibility check, the capacity and dimensions of this floating dry dock is found suitable for the construction of all the types of submarines which are currently under consideration by the Polish Navy.

floating dry‐docks/ floating docks, design, docking, structure, load, stability, ballast --- Ingénierie, informatique & technologie > Ingénierie civile

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La société CACTUS S.A. a le souhait de supprimer la livraison directe au point de vente pour les produits liés à son entrepôt "alimentaire". Cependant, les dirigeants de l'entreprise souhaitent connaître l'impact de cette suppression sur les installations existantes : sont-elles suffisantes ? De quoi avons-nous besoin en termes d'infrastructures? 
Afin de répondre à cette question, nous allons procéder en plusieurs étapes.
Tout d'abord, nous effectuerons une analyse ABC qui visera à mettre en évidence les produits les plus adaptés au stockage en dépôt. 
Deuxièmement, sur la base des résultats obtenus par l'analyse ABC et après avoir étudié la capacité de l'entrepôt "alimentaire", nous allons allouer un maximum de produits à l'entrepôt. En effet, la société est prête à investir dans de nouvelles installations à condition que les installations existantes soient pleinement utilisées. 
Troisièmement, avec les produits restants, nous allons étudier dans quelle mesure ils peuvent suivre le cross-docking. À cette fin, nous étudierons plusieurs aspects d'un cross-dock : les quais de chargement et de déchargement, la zone de stockage temporaire, la zone de chargement et de déchargement, l'équipement nécessaire, la forme et la taille du cross-dock. Cela nous permettra de déterminer si le cross-dock actuel est suffisant et, si ce n'est pas le cas, quel serait le cross-dock optimal. 
Sur la base des résultats obtenus, des recommandations seront proposées afin de permettre à la direction de CACTUS S.A. de prendre les meilleures décisions possibles.

Supply Chain --- Cross-docking --- Warehousing --- Direct Shipping --- Analyse ABC --- Sciences économiques & de gestion > Production, distribution & gestion de la chaîne logistique

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The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions.

Medicine --- Pharmaceutical industries --- COVID-19 --- drug repurposing --- topological data analysis --- persistent Betti function --- SARS-CoV-2 --- network-based pharmacology --- combination therapy --- nucleoside GS-441524 --- fluoxetine --- synergy --- antidepressant --- natural compounds --- QSAR --- molecular docking --- drug repositioning --- UK Biobank --- vaccine --- LC-2/ad cell line --- drug discovery --- docking --- MM-GBSA calculation --- molecular dynamics --- cytotoxicity assay --- GWAS --- multiple sclerosis --- oxidative stress --- repurposing --- ADME-Tox --- bioinformatics --- complex network analysis --- modularity clustering --- ATC code --- hidradenitis suppurativa --- acne inversa --- transcriptome --- proteome --- comorbid disorder --- biomarker --- signaling pathway --- druggable gene --- drug-repositioning --- MEK inhibitor --- MM/GBSA --- Glide docking --- MD simulation --- MM/PBSA --- single-cell RNA sequencing --- pulmonary fibrosis --- biological networks --- p38α MAPK --- allosteric inhibitors --- in silico screening --- computer-aided drug discovery --- network analysis --- psychiatric disorders --- medications --- psychiatry --- mental disorders --- toxoplasmosis --- Toxoplasma gondii --- in vitro screening --- drug targets --- drug-disease interaction --- target-disease interaction --- DPP4 inhibitors --- lipid rafts

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Marine habitats are promising sources to identify novel organisms and compounds. A total of 70% of the planet’s surface is covered by ocean, and little is known about the biosphere within these habitats. In the last few years, numerous novel bioactive compounds or secondary metabolites from marine environments have been described. This is, and will be, a promising source of candidate compounds in pharma research and chemical biology. In recent years, a number of novel techniques have been introduced to the field and it has become easier to actually (bio-)prospect compounds such as enzyme inhibitors. Those novel compounds then need to be characterized and evaluated in comparison to well-known representatives. This Special Issue focuses on the description of novel enzyme inhibitors of marine origin, including bioprospecting, omic approaches, and structural and mechanistic aspects.

Research & information: general --- sponge Monanchora pulchra --- pentacyclic guanidine alkaloids --- GH36 α-galactosidase --- GH109 α-N-acetylgalactosaminidase --- slow-binding irreversible inhibitor --- monanchomycalin B --- monanhocidin A --- normonanhocidin A --- Alzheimer′s disease --- BACE1 --- acetylcholinesterase --- in silico docking --- phlorotannins --- Ulva intestinalis --- ACE inhibitory peptide --- optimization --- purification --- structural identification --- molecular docking --- secondary metabolites --- Mycosphaerella sp. --- asperchalasine --- α-glucosidase --- kinase inhibitors --- drug development --- marine natural products --- inhibitor --- macroalgae --- marine fish --- protease --- Ulva ohnoi --- functional annotation --- structure–function relation --- natural products --- bioactives --- enzyme inhibition --- inactivation --- marine bacteria --- marine fungi --- marine sponges