Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Real-world and clinical trial data support that clozapine is the only effective antipsychotic for treatment resistant schizophrenia and other severe mental illnesses. Clozapine also reduces rates of suicidality, psychiatric hospitalization and all-cause mortality. However, clozapine is underutilized for two reasons: misunderstandings of its efficacy benefits and misapprehension of, limited knowledge or misinformation about the management of treatment related risks and adverse effects. In response to worldwide efforts to promote clozapine use, this user-friendly Handbook provides clinicians with evidence-based approaches for patient management, as well as logical approaches to the management of clinical situations and adverse effects. It outlines clearly the rationale for specific management decisions and prioritises the options based on this logic. This Handbook is designed for use by clinicians worldwide and is essential reading for all mental health care professionals.

Clozapine --- Antipsychotic Agents --- Schizophrenia --- administration & dosage --- therapeutic use --- adverse effects --- drug therapy --- Neuroleptiques --- Schizophrénie --- Effets secondaires. --- Thérapeutique. --- Modes d'administration. --- Chimiothérapie. --- Clozapine - administration & dosage --- Clozapine - therapeutic use --- Clozapine - adverse effects --- Schizophrenia - drug therapy --- Antipsychotic Agents. --- administration & dosage. --- therapeutic use. --- adverse effects. --- drug therapy. --- Modes d'administration --- Schizophrénie --- Thérapeutique. --- Chimiothérapie. --- Clozapine.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

NEUROPEPTIDES --- IMMUNOLOGY --- REGULATION --- CHOLECYSTOKININ --- DOPAMINE --- NEUROTENSIN --- FLUOROQUINOLONES --- QUINOLONES --- ANTIPSYCHOTIC AGENTS --- CLOZAPINE --- I.M.A.O.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Antiviral agents are used for the treatment of viral diseases. Antiviral drugs have been successfully developed and used clinically for a limited number of important human viral diseases notably caused by human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), herpes, and influenza viruses. Despite the successes of these antiviral drugs, issues with drug resistance and toxicity remain challenging. These challenges are driving research to identify new drug candidates and to investigate novel drug targets to develop new mechanistic drug classes. Antiviral agents are not available against many viruses that cause human disease and economic burdens; in particular, the development of antiviral agents against emerging, re-emerging, and neglected viruses is increasingly becoming a priority. This book includes six review articles that discuss new antiviral strategies. The reviews either discuss advances relating to a specific virus or new therapeutic targets and approaches. The book includes 15 original research articles reporting new antiviral agents against a variety of clinically and economically important viruses and studies into the prevalence or acquisition of drug resistance. Overall, this book is an exciting collection of new research and ideas relating to the development of antiviral agents.

Research & information: general --- Biology, life sciences --- Zika virus --- nucleoside analogues --- antiviral agents --- NS5 --- prodrugs --- ProTides --- neural stem cells --- RNA-dependent RNA polymerase --- cytomegalovirus --- latent infection --- TALEN --- Surveyor nuclease mutation detection assay --- ie-1 gene --- quantitative real-time PCR --- Epstein-Barr virus --- herpes viruses --- lytic gene expression --- Burkitt lymphoma cells --- clozapine --- antipsychotic drug --- antiviral drug --- enteroviruses --- coxsackievirus B4 --- persistent infection --- fluoxetine --- resistance --- mutations --- herpes B virus --- macacine herpesvirus-1 --- genistein --- flavonoids --- acyclovir --- ganciclovir --- Plantago asiatica --- Clerodendrum trichotomum --- RSV --- therapeutic effects --- acteoside --- human antimicrobial peptides --- antiviral strategies --- defensins --- cathelicidins --- hepcidins --- transferrins --- influenza A virus --- brevilin A --- antiviral --- sesquiterpene lactone --- replication --- PRRSV --- polyethylenimine --- PEI --- virion internalization --- endocytosis --- HIV --- pediatrics --- Ethiopia --- pre-treatment drug resistance --- combination antiretroviral therapy (cART) --- dried plasma spots --- dried blood spots --- sphingolipids --- glycosphingolipids --- viruses --- lipid biosynthesis --- flavivirus --- Japanese encephalitis virus --- furin inhibitor --- precursor membrane protein --- measles virus --- central nervous system --- tropism --- treatments --- porcine reproductive and respiratory syndrome virus --- ginsenoside Rg1 --- antiviral activity --- pro-inflammatory factor --- NF-κB signaling pathway --- acute/latent infection --- congenital infection --- antiviral agent --- therapeutic strategies --- nucleic acid-based therapeutic approach --- HCMV vaccine --- adoptive cell therapy --- Rev response element --- chemical footprinting --- SHAPE --- drug discovery --- branched peptides --- herpesvirus --- immediate-early --- IE1 --- IE2 --- ribozyme --- RNA interference --- CRISPR/Cas --- small molecule --- orthohantavirus --- phenyl-benzotriazoles --- C-FRA --- Porcine circovirus type 2 --- epigallocatechin gallate --- heparan sulfate --- antiviral effect --- virus attachment --- microvirin --- lectin --- human immunodeficiency virus --- hepatitis C virus --- antiviral inhibitor --- non-immunogenic --- viral entry --- protein drugs --- LUMS1 --- oleanane-type derivatives --- influenza A virus (IAV) --- virus entry inhibitors --- hemagglutinin (HA)

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book includes articles written by over 80 specialists from many countries that demonstrate the biological functions of ultrasonic vocalizations and how they are used in studies of vocal expression of emotional states and in numerous animal models of neuropsychiatric diseases and disorders. Results of investigations of emissions of ultrasonic vocalizations are useful in studies of emotional disturbances, affective disorders, autism spectrum disorders, addiction, developmental abnormalities, and many other pathologies.

Medicine --- Neurosciences --- ultrasonic vocalization --- maternal immune activation --- autism --- communication --- rat --- sex differences --- social play --- rats --- anxiety --- observational fear learning --- USV --- maternal separation --- pup --- vasopressin antagonists --- righting reflex --- negative geotaxis --- ACTH --- corticosterone --- Brattleboro rat --- larynx --- female --- male --- 50-khz ultrasonic vocalizations (USVs) --- individual differences --- chronic variable stress (CVS) --- dopamine --- nucleus accumbens --- microdialysis --- evolution of vocalization --- 22 kHz calls --- 50 kHz calls --- infant isolation calls --- emotional arousal --- mesolimbic dopaminergic system --- mesolimbic cholinergic system --- hedonia --- ultrasonic vocalizations --- cognitive development --- respiration --- brain oscillations --- Cav1.2 --- calcium --- animal model --- rough-and-tumble play --- social approach --- playback --- social contact call --- alarm call --- social buffering --- distress --- emotional contagion --- fear contagion --- aversive state --- automated scoring --- addiction --- mental health --- machine learning --- drug discovery --- drug development --- Parkinson's disease --- alpha-synuclein --- 6-OHDA --- Pink1 --- DJ1 --- exercise --- pharmacology --- pathology --- hypervigilance --- hyperreactivity --- exaggerated reactivity --- generalization --- PTSD --- depression --- heart rate --- Wistar --- 22-kHz calls --- 50-kHz calls --- affect --- aversion --- NOR --- reward --- working memory --- Y maze --- opioids --- fentanyl --- self-administration --- play --- food --- dam-pup interaction --- ethanol --- pup isolation --- rat pup --- 50 kHz vocalizations --- 22 kHz vocalizations --- amphetamine --- chemogenetics --- clozapine-n-oxide --- UMAP --- males --- females --- vocalizations --- fear extinction --- pain