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ANTIBODY AFFINITY

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Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics.

antibody engineering --- antibody discovery --- therapeutic antibody --- diagnostic antibody --- single-domain antibody

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Immunoglobulins. --- Antibody diversity --- Immunogenetics

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B-LYMPHOCYTES --- ANTIBODY FORMATION

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Immunopharmacology --- Immunotoxicology --- Allergy and Immunology --- Immune System --- Pharmacology --- drug effects --- Immunotoxins --- Communicable Diseases --- Immunopharmacology. --- Immunotoxicology. --- Immunology. --- Pharmacology. --- Toxicology. --- Immunotoxins. --- Allergy and Immunology. --- Communicable Diseases. --- Immunologic toxicology --- Immunotoxicity --- Pharmacoimmunology --- Infectious Diseases --- Communicable Disease --- Disease, Communicable --- Disease, Infectious --- Diseases, Communicable --- Diseases, Infectious --- Infectious Disease --- Pharmacologies --- Pharmaceutical Preparations --- Allergy Specialty --- Allergy, Immunology --- Immunology and Allergy --- Immunology, Allergy --- Immunology --- Specialty, Allergy --- Affinotoxins --- Chimeric Toxin --- Immunotoxin --- Monoclonal Antibody-Toxin Conjugates --- Toxin Carrier --- Toxin Conjugate --- Antibody-Toxin Conjugates --- Antibody-Toxin Hybrids --- Chimeric Toxins --- Cytotoxin-Antibody Conjugates --- Targeted Toxins --- Toxin Carriers --- Toxin Conjugates --- Toxin-Antibody Conjugates --- Toxin-Antibody Hybrids --- Toxins, Chimeric --- Toxins, Targeted --- Antibody Toxin Conjugates --- Antibody Toxin Hybrids --- Antibody-Toxin Conjugates, Monoclonal --- Carrier, Toxin --- Carriers, Toxin --- Conjugate, Toxin --- Conjugates, Antibody-Toxin --- Conjugates, Cytotoxin-Antibody --- Conjugates, Monoclonal Antibody-Toxin --- Conjugates, Toxin --- Conjugates, Toxin-Antibody --- Cytotoxin Antibody Conjugates --- Hybrids, Antibody-Toxin --- Hybrids, Toxin-Antibody --- Monoclonal Antibody Toxin Conjugates --- Toxin Antibody Conjugates --- Toxin Antibody Hybrids --- Toxin, Chimeric --- pharmacology --- Immunopathology --- Toxicology --- Disease Outbreaks --- Disease Transmission, Infectious --- Recombinant Fusion Proteins --- Antibodies, Bispecific --- Affinotoxin --- Antibody-Toxin Conjugate --- Antibody-Toxin Hybrid --- Cytotoxin-Antibody Conjugate --- Monoclonal Antibody-Toxin Conjugate --- Targeted Toxin --- Toxin-Antibody Conjugate --- Toxin-Antibody Hybrid --- Antibody Toxin Conjugate --- Antibody Toxin Hybrid --- Antibody-Toxin Conjugate, Monoclonal --- Conjugate, Antibody-Toxin --- Conjugate, Cytotoxin-Antibody --- Conjugate, Monoclonal Antibody-Toxin --- Conjugate, Toxin-Antibody --- Cytotoxin Antibody Conjugate --- Hybrid, Antibody-Toxin --- Hybrid, Toxin-Antibody --- Monoclonal Antibody Toxin Conjugate --- Toxin Antibody Conjugate --- Toxin Antibody Hybrid --- Toxin, Targeted