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This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage—the first step in carcinogenesis—must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.

Humanities --- Social interaction --- graphene oxide --- reduced graphene oxide --- micronucleus --- oxidative stress --- safer-by-design --- tungsten --- nanoparticles --- tritiated particles --- in vitro testing --- cytotoxicity --- micronuclei formation --- DNA damage --- epigenetics --- DNA methylation --- BEAS-2B cells. --- polystyrene nanoparticles --- nanoplastics --- genotoxicity --- Hs27 human fibroblasts --- comet assay --- FPG enzyme --- TiO2NP --- SiO2NP --- ZnONP --- CeO2NP --- AgNP --- multi-walled carbon nanotubes (MWCNT) --- titanium dioxide nanoparticles --- lincomycin --- human amniotic cells --- in vitro genotoxicity --- apoptosis --- nanotoxicology --- metal oxides --- high throughput screening --- micronucleus assay --- nanomaterial --- aluminum --- oral route --- gut --- liver --- V79 cells --- Hprt --- advanced in vitro model --- hepatotoxicity --- liver spheroids --- 3D culture --- HepG2 --- nongenotoxic silver nanoparticles --- genotoxic --- cytotoxic --- antioxidant activity --- silver ions --- Allium cepa --- metal/coating agent ratio