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Hyperbaric oxygen treatment (HBO2) is a widely accepted adjuvant therapy in various health conditions that exhibit impaired tissue blood flow. At high pressures, the delivery of the dissolved oxygen in plasma is enhanced, which contributes to better tissue oxygenation, cellular metabolism and ultimately, healing. However, this is not the only beneficial outcome of HBO2 treatment since oxygen is a highly reactive molecule and can induce upregulation of many enzymatic systems in the cell at the cellular, genetic and molecular level. Particularly, vascular/endothelial function is affected by the HBO2. Our understanding of these mechanisms is still emerging. There have been many controversies related to the HBO2 protocols and indications. As well as exhibiting beneficiary effects on the tissue perfusion, it is known that HBO2 demonstrates high toxicity at higher pressures, due to increased oxidative stress and barotrauma. On the other hand, there is a lack of translation of the knowledge on the mechanisms of action of HBO2 obtained from the experimental research to the clinical practice. Thus, this book presents the reader with an overview of the current knowledge on the mechanisms of HBO2 effects in various experimental models and clinical treatment protocols, in an attempt to provide a better understanding of how and when HBO2 should be used as an effective therapy without unwanted side effects.

Physician practice patterns. --- Clinical practice patterns --- Clinical practice variations --- Medical practice patterns --- Physician profiling --- Physicians' practice patterns --- Practice patterns, Physician --- Profiling, Physician --- Medical care --- Utilization review --- Medicine --- Emergency Medicine --- Health Sciences

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This is a detailed manual giving a step by step approach to undertaking the pharmacovigilance of antiretrovirals. it is intended to be a source of practical advice for Pharmacovigilance Centres and health professionals involved in HIV/AIDS prevention and treatment programmes. There is an urgent need to develop robust pharmacovigilance systems for antiretrovirals particularly in resource-limited settings. This detailed manual gives a step by step approach to undertaking the pharmacovigilance of these medicines. Good pharmacovigilance will identify the risks in the shortest possible time after t

Antiretroviral agents. --- Drug Monitoring. --- Drug monitoring -- Handbooks, manuals, etc. --- Drug Utilization Review -- methods. --- Antiretroviral agents --- Drug monitoring --- Drug Utilization Review --- Adverse Drug Reaction Reporting Systems --- Methods --- Drug Monitoring --- Handbooks --- Anti-Retroviral Agents --- Drug Information Services --- Drug Utilization --- Publication Formats --- Antiviral Agents --- Utilization Review --- Monitoring, Physiologic --- Investigative Techniques --- Product Surveillance, Postmarketing --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Evaluation Studies as Topic --- Pharmaceutical Services --- Information Services --- Publication Characteristics --- Anti-Infective Agents --- Pharmacy Administration --- Diagnostic Techniques and Procedures --- Quality Assurance, Health Care --- Quality of Health Care --- Health Services --- Organization and Administration --- Diagnosis --- Health Services Administration --- Therapeutic Uses --- Information Science --- Health Care Quality, Access, and Evaluation --- Health Care --- Pharmacologic Actions --- Health Care Facilities, Manpower, and Services --- Chemical Actions and Uses --- Chemicals and Drugs --- Clinical Immunology --- Medicine --- Health & Biological Sciences --- Drugs --- Monitoring, Drug --- Therapeutic drug monitoring --- Anti-retroviral agents --- Antiretroviral drugs --- Antiretrovirals --- Monitoring --- Patient monitoring --- Antiviral agents --- Analysis --- Testing

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Comprehensive, thoroughly updated, and expanded, Neuromuscular Disorders in Clinical Practice, Second Edition encompasses all disorders of the peripheral nervous system, covering all aspects of neuromuscular diseases from diagnosis to treatment.  Mirroring the first book, this two-volume edition is divided into two parts.  Part one discusses the approach to neuromuscular disorders, covering principles and basics, neuromuscular investigations, and assessment and treatment of neurological disorders.  Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies, and miscellaneous neuromuscular disorders and syndromes.  Neuromuscular Disorders in Clinical Practice, Second Edition is intended to serve as a comprehensive text for both novice and experienced practitioners.  General neurologists as well as specialists in neuromuscular medicine and trainees in neuromuscular medicine, clinical neurophysiology and electromyography should find this book inclusive, comprehensive, practical and highly clinically focused.  Additionally, specialists in physical medicine and rehabilitation, rheumatology, neurosurgery, and orthopedics will find the book of great value in their practice.

Neuromuscular diseases. --- Physician practice patterns. --- Clinical practice patterns --- Clinical practice variations --- Medical practice patterns --- Physician profiling --- Physicians' practice patterns --- Practice patterns, Physician --- Profiling, Physician --- Neuromotor disorders --- Neuromuscular disorders --- Medicine. --- Human genetics. --- Internal medicine. --- Rheumatology. --- Neurology. --- Medicine & Public Health. --- Internal Medicine. --- Human Genetics. --- Medical care --- Muscles --- Nervous system --- Utilization review --- Diseases --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Medicine, Internal --- Medicine --- Internal medicine --- Connective tissues --- Joints --- Neuropsychiatry --- Neurology .

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""The Handbook"" is a detailed manual giving a step by step approach to undertaking the pharmacovigilance of antimalarials. It is intended to be a source of practical advice for pharmacovigilance centres. It provides information on spontaneous reporting of adverse drug reactions as a complement to other WHO publications. In addition, it provides details on how to conduct cohort event monitoring, which is a method of active safety surveillance collecting information on all adverse events occurring after treatment. It also details how to perform causality assessment and signal identification, ap

Adverse Drug Reaction Reporting Systems. --- Antimalarials -- standards. --- Antimalarials. --- Drug Monitoring. --- Drug Utilization Review -- methods. --- Pharmacoepidemiology -- methods. --- Product Surveillance, Postmarketing. --- Drug monitoring --- Antimalarials --- Drug Monitoring --- Drug Utilization Review --- Product Surveillance, Postmarketing --- Adverse Drug Reaction Reporting Systems --- Pharmacoepidemiology --- Methods --- Utilization Review --- Antiprotozoal Agents --- Investigative Techniques --- Drug Utilization --- Pharmacology --- Epidemiology --- Evaluation Studies as Topic --- Monitoring, Physiologic --- Quality of Health Care --- Quality Assurance, Health Care --- Public Health --- Health Occupations --- Biological Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diagnostic Techniques and Procedures --- Pharmacy Administration --- Antiparasitic Agents --- Disciplines and Occupations --- Medicine --- Health Services Administration --- Natural Science Disciplines --- Health Care Quality, Access, and Evaluation --- Organization and Administration --- Diagnosis --- Anti-Infective Agents --- Therapeutic Uses --- Health Care --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Side effects --- Pharmaceutical Epidemiology --- Epidemiology, Pharmaceutical --- Epidemiologies, Pharmaceutical --- Pharmaceutical Epidemiologies --- Drug Reaction Reporting Systems, Adverse --- Product Surveillance, Post-Marketing --- Drug Surveillance, Postmarketing --- Evaluation Studies, Postmarketing --- Postmarketing Product Surveillance --- Drug Surveillances, Postmarketing --- Evaluation Study, Postmarketing --- Post-Marketing Product Surveillance --- Post-Marketing Product Surveillances --- Postmarketing Drug Surveillance --- Postmarketing Drug Surveillances --- Postmarketing Evaluation Studies --- Postmarketing Evaluation Study --- Postmarketing Product Surveillances --- Product Surveillance, Post Marketing --- Product Surveillances, Post-Marketing --- Product Surveillances, Postmarketing --- Studies, Postmarketing Evaluation --- Study, Postmarketing Evaluation --- Surveillance, Post-Marketing Product --- Surveillance, Postmarketing Drug --- Surveillance, Postmarketing Product --- Surveillances, Post-Marketing Product --- Surveillances, Postmarketing Drug --- Surveillances, Postmarketing Product --- Schizonticides --- Agents, Antiprotozoal --- Review, Utilization --- Reviews, Utilization --- Utilization Reviews --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Anti-Malarials --- Antimalarial Agents --- Antimalarial Drugs --- Agents, Antimalarial --- Anti Malarials --- Drugs, Antimalarial --- Diagnostic Technics and Procedures --- Technics and Procedures, Diagnostic --- Techniques and Procedures, Diagnostic --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Health Professions --- Health Occupation --- Health Profession --- Occupation, Health --- Occupations, Health --- Profession, Health --- Professions, Health --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Antiparasitic Drugs --- Antiparasitics --- Parasiticides --- Agents, Antiparasitic --- Drugs, Antiparasitic --- Administration, Pharmacy --- Administrations, Pharmacy --- Pharmacy Administrations --- Quality of Care --- Quality of Healthcare --- Care Qualities --- Care Quality --- Health Care Quality --- Healthcare Quality --- Monitoring, Physiological --- Physiologic Monitoring --- Patient Monitoring --- Monitoring, Patient --- Physiological Monitoring --- Critique --- Evaluation --- Evaluation Indexes --- Evaluation Methodology --- Evaluation Report --- Evaluation Research --- Methodology, Evaluation --- Pre-Post Tests --- Qualitative Evaluation --- Quantitative Evaluation --- Theoretical Effectiveness --- Use-Effectiveness --- Critiques --- Effectiveness, Theoretical --- Evaluation Methodologies --- Evaluation Reports --- Evaluation, Qualitative --- Evaluation, Quantitative --- Evaluations --- Evaluations, Qualitative --- Evaluations, Quantitative --- Indexes, Evaluation --- Methodologies, Evaluation --- Pre Post Tests --- Pre-Post Test --- Qualitative Evaluations --- Quantitative Evaluations --- Report, Evaluation --- Reports, Evaluation --- Research, Evaluation --- Test, Pre-Post --- Tests, Pre-Post --- Use Effectiveness --- Disease --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Public --- Health Care Quality Assessment --- Health Care Quality Assurance --- Healthcare Quality Assessment --- Healthcare Quality Assurance --- Quality Assessment, Healthcare --- Quality Assurance, Healthcare --- Quality Assessment, Health Care --- Assessment, Healthcare Quality --- Assessments, Healthcare Quality --- Assurance, Healthcare Quality --- Assurances, Healthcare Quality --- Healthcare Quality Assessments --- Healthcare Quality Assurances --- Quality Assessments, Healthcare --- Quality Assurances, Healthcare --- Utilization, Drug --- Drug Utilizations --- Utilizations, Drug --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Pharmacologies --- Pharmaceutical Preparations --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Community-Based Distribution --- Contraceptive Distribution --- Delivery of Healthcare --- Dental Care Delivery --- Distribution, Non-Clinical --- Distribution, Nonclinical --- Distributional Activities --- Healthcare --- Healthcare Delivery --- Healthcare Systems --- Non-Clinical Distribution --- Nonclinical Distribution --- Delivery of Dental Care --- Health Care Delivery --- Health Care Systems --- Activities, Distributional --- Activity, Distributional --- Care, Health --- Community Based Distribution --- Community-Based Distributions --- Contraceptive Distributions --- Deliveries, Healthcare --- Delivery, Dental Care --- Delivery, Health Care --- Delivery, Healthcare --- Distribution, Community-Based --- Distribution, Contraceptive --- Distribution, Non Clinical --- Distributional Activity --- Distributions, Community-Based --- Distributions, Contraceptive --- Distributions, Non-Clinical --- Distributions, Nonclinical --- Health Care System --- Healthcare Deliveries --- Healthcare System --- Non Clinical Distribution --- Non-Clinical Distributions --- Nonclinical Distributions --- System, Health Care --- System, Healthcare --- Systems, Health Care --- Systems, Healthcare --- Therapeutic Effects --- Effects, Therapeutic --- Uses, Therapeutic --- Anti-Microbial Agents --- Antiinfective Agents --- Antimicrobial Agents --- Microbicides --- Agents, Anti-Infective --- Agents, Anti-Microbial --- Agents, Antiinfective --- Agents, Antimicrobial --- Anti Infective Agents --- Anti Microbial Agents --- Antemortem Diagnosis --- Diagnoses and Examinations --- Examinations and Diagnoses --- Postmortem Diagnosis --- Antemortem Diagnoses --- Diagnoses --- Diagnoses, Antemortem --- Diagnoses, Postmortem --- Diagnosis, Antemortem --- Diagnosis, Postmortem --- Postmortem Diagnoses --- Administration and Organization --- Administrative Technics --- Administrative Techniques --- Coordination, Administrative --- Logistics --- Supervision --- Technics, Administrative --- Techniques, Administrative --- Administration --- Administrative Coordination --- Administrative Technic --- Administrative Technique --- Technic, Administrative --- Technique, Administrative --- Healthcare Quality, Access, and Evaluation --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Administration, Health Services --- Health Services --- Drug Utilization Evaluation --- Drug-Use Review --- Evaluation, Drug Utilization --- Review, Drug Utilization --- Review, Drug-Use --- Utilization Review, Drug --- Drug Use Review --- Drug Utilization Evaluations --- Drug Utilization Reviews --- Drug-Use Reviews --- Evaluations, Drug Utilization --- Review, Drug Use --- Reviews, Drug Utilization --- Reviews, Drug-Use --- Utilization Evaluation, Drug --- Utilization Evaluations, Drug --- Utilization Reviews, Drug --- Monitoring, Drug --- Therapeutic Drug Monitoring --- Drug Monitoring, Therapeutic --- Monitoring, Therapeutic Drug --- Antimalarial agents --- Drugs --- Therapeutic drug monitoring --- methods --- epidemiology --- pharmacology --- diagnosis --- organization & administration --- Monitoring --- Safety-Based Drug Withdrawals --- Parasites --- Protozoan Infections --- Professional Staff Committees --- Malaria --- Plasmodium --- Antirheumatic Agents --- Sensitivity and Specificity --- Occupations --- Pharmacy Audit --- Audit, Pharmacy --- Pharmacy Audits --- Community Health --- Health, Community --- Preventive Medicine --- Education, Public Health Professional --- Off-Label Use --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Infection --- Pharmacovigilance --- Antiprotozoal agents --- Patient monitoring --- Chemotherapy --- Analysis --- Testing --- Health Workforce --- Infections --- Anti-Malarial --- Antimalarial --- Antimalarial Agent --- Antimalarial Drug --- Agent, Antimalarial --- Anti Malarial --- Drug, Antimalarial --- Diagnostic Testing --- Testing, Diagnostic --- Antiparasitic --- Social Epidemiology --- Epidemiologies, Social --- Epidemiology, Social --- Social Epidemiologies --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Use, Therapeutic --- Anti-Infective Agent --- Anti-Microbial Agent --- Antimicrobial Agent --- Microbicide --- Agent, Anti-Infective --- Agent, Anti-Microbial --- Agent, Antimicrobial --- Anti Infective Agent --- Anti Microbial Agent --- Diagnose --- Techniques --- Technique --- Delivery of Health Care. --- Side effects.